Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.

Abstract:

:Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on reference region spontaneous brain activity (SBA-rr) using resting-state functional magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in patients with mild cognitive impairment. Patients (N = 62, [43 Aβ-positive]) from the Alzheimer's Disease Neuroimaging Initiative were divided into Aβ-positive and Aβ-negative groups via prespecified cerebrospinal fluid Aβ42 or 18F-florbetapir positron emission tomography standardized uptake value ratio cutoffs measured at baseline. We analyzed interaction of biomarker-confirmed Aβ status with SBA-rr change over a 2-year period using mixed-effects modeling. SBA-rr differences between Aβ-positive and Aβ-negative subjects increased significantly over time within subsystems of the default and visual networks. Changes exhibit an interaction with memory performance over time but were independent of glucose metabolism. Results reinforce the value of resting-state functional magnetic resonance imaging in evaluating Alzheimer''s disease progression and suggest spontaneous neuronal activity changes are concomitant with cognitive decline.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Avants BB,Hutchison RM,Mikulskis A,Salinas-Valenzuela C,Hargreaves R,Beaver J,Chiao P,Alzheimer's Disease Neuroimaging Initiative.

doi

10.1016/j.neurobiolaging.2018.10.002

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

191-201

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(18)30358-0

journal_volume

74

pub_type

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