Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.


:Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on reference region spontaneous brain activity (SBA-rr) using resting-state functional magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in patients with mild cognitive impairment. Patients (N = 62, [43 Aβ-positive]) from the Alzheimer's Disease Neuroimaging Initiative were divided into Aβ-positive and Aβ-negative groups via prespecified cerebrospinal fluid Aβ42 or 18F-florbetapir positron emission tomography standardized uptake value ratio cutoffs measured at baseline. We analyzed interaction of biomarker-confirmed Aβ status with SBA-rr change over a 2-year period using mixed-effects modeling. SBA-rr differences between Aβ-positive and Aβ-negative subjects increased significantly over time within subsystems of the default and visual networks. Changes exhibit an interaction with memory performance over time but were independent of glucose metabolism. Results reinforce the value of resting-state functional magnetic resonance imaging in evaluating Alzheimer''s disease progression and suggest spontaneous neuronal activity changes are concomitant with cognitive decline.


Neurobiol Aging


Neurobiology of aging


Avants BB,Hutchison RM,Mikulskis A,Salinas-Valenzuela C,Hargreaves R,Beaver J,Chiao P,Alzheimer's Disease Neuroimaging Initiative.




Has Abstract


2019-02-01 00:00:00












  • An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.

    abstract::SORL1 encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer's disease (AD). In the existing literature, SORL1 is insufficiently described at the t...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Blechingberg J,Poulsen ASA,Kjølby M,Monti G,Allen M,Ivarsen AK,Lincoln SJ,Thotakura G,Vægter CB,Ertekin-Taner N,Nykjær A,Andersen OM

    更新日期:2018-11-01 00:00:00

  • Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

    abstract::Elevated serum and cerebrospinal fluid concentrations of S100β, a protein predominantly found in glia, are associated with intracranial injury and neurodegeneration, although concentrations are also influenced by several other factors. The longitudinal association between serum S100β concentrations and brain health in...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cox SR,Allerhand M,Ritchie SJ,Muñoz Maniega S,Valdés Hernández M,Harris SE,Dickie DA,Anblagan D,Aribisala BS,Morris Z,Sherwood R,Abbott NJ,Starr JM,Bastin ME,Wardlaw JM,Deary IJ

    更新日期:2018-09-01 00:00:00

  • Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging.

    abstract::Dogs exhibit both neuroanatomical and cognitive changes as a function of age that parallel those seen in aging humans. This study describes in vivo changes in neuroanatomical and cerebrovascular characteristics of the canine brain as a function of age in a group of dogs ranging from 4 to 15 years old. Dynamic contrast...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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  • Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain.

    abstract::Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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  • Widespread distribution of tauopathy in preclinical Alzheimer's disease.

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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  • Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice.

    abstract::We evaluated the autophagy-lysosomal pathway and membrane fluidity in brain cells and mitochondrial membranes obtained from senescence-accelerated (SAMP(8)) and senescence-resistant (SAMR(1)) mice at 5 and 10 months of age. Moreover, we studied whether chronic treatment from age 1 to 10 months with melatonin stabilize...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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    更新日期:2011-11-01 00:00:00

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    abstract::The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) brains. In this study, we evaluated the therapeutic effect of berberine (BBR) extracted from Coptis chinensis Franch, a Chinese medicinal herb, on...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


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  • The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder.

    abstract::The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R vari...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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  • Comparison of frailty of primary neurons, embryonic, and aging mouse cortical layers.

    abstract::Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and su...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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  • Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.

    abstract::In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章


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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: West MJ

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  • Behavioral tagging and capture: long-term memory decline in middle-aged rats.

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gros A,Wang SH

    更新日期:2018-07-01 00:00:00

  • Usual vs. successful aging: some notes on experiential factors.

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    journal_title:Neurobiology of aging

    pub_type: 评论,杂志文章


    authors: Black JE,Isaacs KR,Greenough WT

    更新日期:1991-07-01 00:00:00

  • Acetylcholine release from striatal slices of young adult and aged Fischer 344 rats.

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Weiler MH

    更新日期:1990-07-01 00:00:00

  • Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging.

    abstract::The impact of many inflammatory diseases is influenced by age-related changes in the activation of resident and circulating myeloid cells. In the eye, a major sight-threatening consequence of age-related macular degeneration is the development of severe choroidal neovascularization (CNV). To identify the molecular pat...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Robbie SJ,Georgiadis A,Barker SE,Duran Y,Smith AJ,Ali RR,Luhmann UFO,Bainbridge JW

    更新日期:2016-04-01 00:00:00

  • Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia.

    abstract::Since the introduction of amyloid imaging nearly 10 years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of antiamyloid therapies. This review will consider the issues involved in the use of amyl...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Klunk WE

    更新日期:2011-12-01 00:00:00

  • Translational gene mapping of cognitive decline.

    abstract::The ability to maintain cognitive function during aging is a complex process subject to genetic and environmental influences. Alzheimer's disease (AD) is the most common disorder causing cognitive decline among the elderly. Among those with AD, there is broad variation in the relationship between AD neuropathology and...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wilmot B,McWeeney SK,Nixon RR,Montine TJ,Laut J,Harrington CA,Kaye JA,Kramer PL

    更新日期:2008-04-01 00:00:00

  • Advancing age alters intracellular calcium buffering in rat adrenergic nerves.

    abstract::There is a marked increase with advancing age of stimulation-evoked neurotransmitter release from vascular adrenergic nerves in the rat, an effect correlated with increased levels of plasma norepinephrine. This increase in norepinephrine release could not be accounted for by an alteration in neuronal and extraneuronal...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


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    更新日期:1996-11-01 00:00:00

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    abstract::The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rodefer JS,Nguyen TN

    更新日期:2008-02-01 00:00:00

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    abstract::Synaptic density in the medial and lateral septal nuclei was examined in 3 and 24-28 months of age Fischer 344 rats. The lateral nucleus had a higher synaptic density than the medial region in both age groups. There were no statistically significant differences in synapse density in either region as a function of age,...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Scheff SW,Scott SA,DeKosky ST

    更新日期:1991-01-01 00:00:00

  • Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.

    abstract::To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Miranda R,Ceckler T,Guillet R,Kellogg CK

    更新日期:1990-03-01 00:00:00

  • Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.

    abstract::The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples available in the world was performed. A series of 93 vCJD UK patients and 1504 UK controls were included in the discovery stage. Our best...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Sanchez-Juan P,Bishop MT,Aulchenko YS,Brandel JP,Rivadeneira F,Struchalin M,Lambert JC,Amouyel P,Combarros O,Sainz J,Carracedo A,Uitterlinden AG,Hofman A,Zerr I,Kretzschmar HA,Laplanche JL,Knight RS,Will RG,van Duijn

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  • Age-related learning and memory deficits in odor-reward association in rats.

    abstract::In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Roman FS,Alescio-Lautier B,Soumireu-Mourat B

    更新日期:1996-01-01 00:00:00

  • The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.

    abstract::While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

    更新日期:2009-05-01 00:00:00

  • Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice.

    abstract::One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (MTs) and functions associated with tau. A potential way to compensate for altered MT function is to use an MT stabilizer, such as epothilone D (EpoD). Previous studies have demonstrated im...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Guo B,Huang Y,Gao Q,Zhou Q

    更新日期:2020-12-01 00:00:00

  • Genetic analysis of DNA methylation and hydroxymethylation genes in Parkinson's disease.

    abstract::DNA methylation is an important regulatory mechanism of Parkinson's disease (PD). To investigate the relationship between DNA methylation and hydroxymethylation genes and PD, we performed gene-targeted sequencing using molecular inversion probes in a Chinese PD population. We sequenced 12 genes related to DNA methylat...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Shu L,Qin L,Min S,Pan H,Zhong J,Guo J,Sun Q,Yan X,Chen C,Tang B,Xu Q

    更新日期:2019-12-01 00:00:00

  • Distinguishing between dementia with Lewy bodies and Alzheimer's disease using metabolic patterns.

    abstract::Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants under...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ye BS,Lee S,Yoo H,Chung SJ,Lee YH,Choi Y,Lee PH,Sohn YH,Yun M

    更新日期:2020-03-01 00:00:00