Abstract：
:Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on reference region spontaneous brain activity (SBA-rr) using resting-state functional magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in patients with mild cognitive impairment. Patients (N = 62, [43 Aβ-positive]) from the Alzheimer's Disease Neuroimaging Initiative were divided into Aβ-positive and Aβ-negative groups via prespecified cerebrospinal fluid Aβ42 or 18F-florbetapir positron emission tomography standardized uptake value ratio cutoffs measured at baseline. We analyzed interaction of biomarker-confirmed Aβ status with SBA-rr change over a 2-year period using mixed-effects modeling. SBA-rr differences between Aβ-positive and Aβ-negative subjects increased significantly over time within subsystems of the default and visual networks. Changes exhibit an interaction with memory performance over time but were independent of glucose metabolism. Results reinforce the value of resting-state functional magnetic resonance imaging in evaluating Alzheimer''s disease progression and suggest spontaneous neuronal activity changes are concomitant with cognitive decline.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Avants BB,Hutchison RM,Mikulskis A,Salinas-Valenzuela C,Hargreaves R,Beaver J,Chiao P,Alzheimer's Disease Neuroimaging Initiative.doi
10.1016/j.neurobiolaging.2018.10.002subject
Has Abstractpub_date
2019-02-01 00:00:00pages
191-201eissn
0197-4580issn
1558-1497pii
S0197-4580(18)30358-0journal_volume
74pub_type
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