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Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.

Abstract：

:The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Ting SK,Chong MS,Kandiah N,Hameed S,Tan L,Au WL,Prakash KM,Pavanni R,Lee TS,Foo JN,Bei JX,Yu XQ,Liu JJ,Zhao Y,Lee WL,Tan EK

doi

10.1016/j.neurobiolaging.2013.04.012

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

2441.e7-8

issue

10

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(13)00165-6

journal_volume

34

pub_type

杂志文章

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