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APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.

Abstract：

:APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and closely related neuroenergetic functions that might be involved in vulnerability to neurodegenerative pathophysiology. These effects highlight the salience of further investigation into the diverse influences of APOE. Therefore, this article reviews the interplay between APOE and neuroenergetics and proposes areas for further investigation. This research might lead to the identification of novel therapeutic targets for the treatment and/or prevention of Alzheimer's disease.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Wolf AB,Caselli RJ,Reiman EM,Valla J

doi

10.1016/j.neurobiolaging.2012.10.011

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1007-17

issue

4

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(12)00522-2

journal_volume

34

pub_type

杂志文章,评审

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