Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain.

abstract：:Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

journal_title：Neurobiology of aging

authors： Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

更新日期：2012-10-01 00:00:00

abstract：:CR1 is a novel Alzheimer's disease (AD) gene identified by genome-wide association studies (GWAS). Recently, we showed that AD risk could be explained by an 18-kilobase insertion responsible for the complement component (3b/4b) receptor 1 (CR1)-S isoform. We investigated the relevance of the CR1 isoforms to AD in a Ca...

journal_title：Neurobiology of aging

authors： Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E

更新日期：2012-12-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

journal_title：Neurobiology of aging

authors： Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

更新日期：2011-11-01 00:00:00

abstract：:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

journal_title：Neurobiology of aging

authors： Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1993-01-01 00:00:00

abstract：:Brain injury increases the risk of Alzheimer's disease (AD) through unknown mechanisms. We studied deposition of amyloid-beta protein (Abeta) in cells exposed to transforming growth factor beta1 (TGFbeta1), a cytokine that regulates cell metabolism during brain injury, and apolipoproteinE (apoE), the major lipid trans...

journal_title：Neurobiology of aging

authors： Mazur-Kolecka B,Frackowiak J,Le Vine H 3rd,Haske T,Evans L,Sukontasup T,Golabek A

更新日期：2003-03-01 00:00:00

abstract：:We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer's disease (AD), we investigated the possibility of an association be...

journal_title：Neurobiology of aging

authors： Corneveaux JJ,Liang WS,Reiman EM,Webster JA,Myers AJ,Zismann VL,Joshipura KD,Pearson JV,Hu-Lince D,Craig DW,Coon KD,Dunckley T,Bandy D,Lee W,Chen K,Beach TG,Mastroeni D,Grover A,Ravid R,Sando SB,Aasly JO,Heun R

更新日期：2010-06-01 00:00:00

abstract：:Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639...

journal_title：Neurobiology of aging

authors： Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

更新日期：2005-07-01 00:00:00

abstract：:Event-related fMRI studies have investigated age-related changes in encoding by identifying greater activity for items that are later remembered than for those that are forgotten (difference in memory, or Dm). The present study used hybrid blocked/event-related analyses to distinguish between transient Dm versus susta...

journal_title：Neurobiology of aging

authors： Dennis NA,Daselaar S,Cabeza R

更新日期：2007-11-01 00:00:00

abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

journal_title：Neurobiology of aging

authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

更新日期：2012-05-01 00:00:00

abstract：:It is widely known that the tau protein that forms the aggregates found in tauopathies like Alzheimer's disease (AD) is hyperphosphorylated. Many of the sites that are hyperphosphorylated in AD can also be found phosphorylated in non-pathological control brains, although to a lesser extend. Among the different kinases...

journal_title：Neurobiology of aging

authors： Hernández F,Lucas JJ,Cuadros R,Avila J

更新日期：2003-12-01 00:00:00

abstract：:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

journal_title：Neurobiology of aging

authors： Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

更新日期：2016-10-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:Demonstrations that grip strength has predictive power in relation to a range of health conditions-even when these are assessed decades later-has motivated claims that hand-grip dynamometry has the potential to serve as a "vital sign" for middle-aged and older adults. Central to this belief has been the assumption tha...

journal_title：Neurobiology of aging

authors： Carson RG

更新日期：2018-11-01 00:00:00

abstract：:The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the hypothesis that it is NFT-bearing neurons that are primarily responsible for the loss of function in AD. Quantitative Golgi postmortem studies from our laborator...

journal_title：Neurobiology of aging

authors： Callahan LM,Coleman PD

更新日期：1995-05-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD). However, little is known about FtMt's functions in the retina and any links to AMD. In this study, we observed age-related increase in FtMt and ...

journal_title：Neurobiology of aging

authors： Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

更新日期：2016-11-01 00:00:00

abstract：:Synaptic density in the medial and lateral septal nuclei was examined in 3 and 24-28 months of age Fischer 344 rats. The lateral nucleus had a higher synaptic density than the medial region in both age groups. There were no statistically significant differences in synapse density in either region as a function of age,...

journal_title：Neurobiology of aging

authors： Scheff SW,Scott SA,DeKosky ST

更新日期：1991-01-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:Zen meditation, a Buddhist practice centered on attentional and postural self-regulation, has been speculated to bring about beneficial long-term effects for the individual, ranging from stress reduction to improvement of cognitive function. In this study, we examined how the regular practice of meditation may affect ...

journal_title：Neurobiology of aging

authors： Pagnoni G,Cekic M

更新日期：2007-10-01 00:00:00

abstract：:Progranulin (PGRN) mutations account for an average of 15% of familial frontotemporal dementia (FTD) cases and 20% of total FTD cases worldwide. Here, we investigated the frequency of PGRN mutations in FTD patients (n = 116) from a clinical cohort of south India and detected one novel mutation located on exon 12 in a ...

journal_title：Neurobiology of aging

authors： Aswathy PM,Jairani PS,Raghavan SK,Verghese J,Gopala S,Srinivas P,Mathuranath PS

更新日期：2016-03-01 00:00:00

abstract：:Insomnia, daytime sleepiness, and nocturnal wandering, so common in the elderly, are caused largely by two specific pathophysiologic processes. Sleep apnea is a condition where respiration pauses during sleep, leading to arousal. Sleep apnea is due either to obstruction in the throat or failure of the central respirat...

journal_title：Neurobiology of aging

authors： Kripke DF,Ancoli-Israel S,Okudaira N

更新日期：1982-01-01 00:00:00

abstract：:Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...

journal_title：Neurobiology of aging

authors： Scheib JL,Höke A

更新日期：2016-09-01 00:00:00

abstract：:While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

journal_title：Neurobiology of aging

authors： Chiueh CC,Nespor SM,Rapoport SI

更新日期：1980-01-01 00:00:00

abstract：:In simple systems, lifespan can be extended by various methods including dietary restriction, mutations in the insulin/insulin-like growth factor (IGF) pathway or mitochondria among other processes. It is widely held that the mechanisms that extend lifespan may be adapted for diminishing age-associated pathologies. We...

journal_title：Neurobiology of aging

authors： Tauffenberger A,Julien C,Parker JA

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

journal_title：Neurobiology of aging

authors： Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

更新日期：2008-05-01 00:00:00

abstract：:A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular ...

journal_title：Neurobiology of aging

authors： Scheibel AB,Duong T

更新日期：1988-01-01 00:00:00

abstract：:Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

journal_title：Neurobiology of aging

authors： Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

更新日期：2013-04-01 00:00:00

abstract：:There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

journal_title：Neurobiology of aging

authors： Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

更新日期：2019-05-01 00:00:00

abstract：:We recently demonstrated that retinal ganglion cell function, optic nerve head parameters and the retinal nerve fiber layer thickness are not altered in early dementia of the Alzheimer type (DAT). Our current objective was to assess whether the function of cells located more distally in the retina is also unaffected b...

journal_title：Neurobiology of aging

authors： Justino L,Kergoat M,Bergman H,Chertkow H,Robillard A,Kergoat H

更新日期：2001-07-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00