Abstract:
OBJECTIVE:We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study. METHOD:Women estrogen users (n = 11) and non-users (n = 9) were studied at baseline and 2 years later. Analyses focused on glucose metabolism in regions previously reported to decline in older persons at risk for Alzheimer's disease (AD) (posterior cingulate and lateral temporal cortex). RESULTS:Region of interest (ROI) analysis at baseline showed no regional differences between women estrogen users and non users. ROI follow-up analysis revealed that women non-users declined significantly in the posterior cingulate cortex (P= 0.04). Statistical parametric mapping (SPM) analysis confirmed a significant decrease in metabolism of the posterior cingulate cortex among non-users at 2-year follow-up (P = 0.004). In contrast, women estrogen users did not exhibit significant metabolic change in the posterior cingulate. CONCLUSIONS:Estrogen use may preserve regional cerebral metabolism and protect against metabolic decline in postmenopausal women, especially in posterior cingulate cortex, the region of the brain found to decline in the earliest stages of AD.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Rasgon NL,Silverman D,Siddarth P,Miller K,Ercoli LM,Elman S,Lavretsky H,Huang SC,Phelps ME,Small GWdoi
10.1016/j.neurobiolaging.2004.03.003subject
Has Abstractpub_date
2005-02-01 00:00:00pages
229-35issue
2eissn
0197-4580issn
1558-1497pii
S0197458004001174journal_volume
26pub_type
临床试验,杂志文章abstract::Alzheimer's disease (AD) involves progressive neurodegeneration in the presence of misfolded proteins and poorly-understood inflammatory changes. However, research has shown that AD is genetically, clinically, and pathologically heterogeneous. In frozen brain samples of frontal cortex (diseased) and cerebellum (nondis...
journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2020.03.017
更新日期:2020-08-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(89)90134-6
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.01.009
更新日期:2013-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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更新日期:1989-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章,随机对照试验
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更新日期:2019-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(97)00034-1
更新日期:1997-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2010.03.005
更新日期:2012-02-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(01)00280-9
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2004.06.014
更新日期:2005-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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更新日期:1997-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(95)02004-7
更新日期:1995-11-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(98)00071-2
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
doi:10.1016/0197-4580(92)90065-6
更新日期:1992-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2005.03.020
更新日期:2006-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2017.03.004
更新日期:2017-08-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.08.038
更新日期:2014-03-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(98)00060-8
更新日期:1998-05-01 00:00:00
abstract::Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical c...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2008.09.002
更新日期:2010-06-01 00:00:00
abstract::Several RNA sequences were tested for age-related changes in prevalence levels in the mouse cerebral cortex, hippocampus, and cerebellum. In all three regions, there were increased levels of RNA for glial fibrillary acidic protein, an astrocyte-specific protein, by RNA gel-blot analysis and by a solution hybridization...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(91)90056-p
更新日期:1991-03-01 00:00:00