Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain.

Abstract:

:Several RNA sequences were tested for age-related changes in prevalence levels in the mouse cerebral cortex, hippocampus, and cerebellum. In all three regions, there were increased levels of RNA for glial fibrillary acidic protein, an astrocyte-specific protein, by RNA gel-blot analysis and by a solution hybridization assay. There was no change in glutamine synthetase mRNA level, another glial protein. The only other mRNA sequence which changed was Thy-1 antigen, a neuronal protein, which decreased slightly in the hippocampus. We conclude that with age there is an age-related increase in glial fibrillary acidic protein RNA prevalence potentially reflecting an increase in the size, number, and/or fibrous character of astrocytes.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Goss JR,Finch CE,Morgan DG

doi

10.1016/0197-4580(91)90056-p

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

165-70

issue

2

eissn

0197-4580

issn

1558-1497

pii

0197-4580(91)90056-P

journal_volume

12

pub_type

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