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Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment.

Abstract：

:We determined whether oxidative stress is an early event in the pathogenesis of sporadic Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions and neurofibrillary pathology in AD and mild cognitive impairment (MCI). Oxidative stress was measured as the percentage of astrocytes expressing heme oxygenase-1 (HO-1) in post mortem temporal cortex and hippocampus after dual HO-1/glial fibrillary acidic protein (GFAP) immunohistochemistry. Glial HO-1 expression in the MCI temporal cortex and hippocampus was significantly greater than in the non-demented group and did not differ from AD values. Astroglial HO-1 expression in the temporal cortex was associated with decreased scores for global cognition, episodic memory, semantic memory and working memory. Hippocampal astroglial HO-1 expression was associated with lower scores for global cognition, semantic memory and perceptual speed. Glial HO-1 immunoreactivity in the temporal cortex, but not hippocampus, correlated with the burden of neurofibrillary pathology. Cortical and hippocampal oxidative stress is a very early event in the pathogenesis of sporadic AD and correlates with the development of specific cognitive deficits in this condition.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Schipper HM,Bennett DA,Liberman A,Bienias JL,Schneider JA,Kelly J,Arvanitakis Z

doi

10.1016/j.neurobiolaging.2005.01.016

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

252-61

issue

2

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(05)00067-9

journal_volume

27

pub_type

杂志文章

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