Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.


:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive material, decreases in intracellular pH (pHi) and alterations in phosphocreatine (PCr) utilization. Prenatal (late gestational) DZ exposure induced lasting, dose-related and age-related alterations in levels of TBA-reactive material and pHi. The results indicate that the prenatal chemical environment can influence cellular metabolism throughout the lifetime of the organism, and that the process of aging can in turn interact with the consequences of prenatal drug exposure.


Neurobiol Aging


Neurobiology of aging


Miranda R,Ceckler T,Guillet R,Kellogg CK




Has Abstract


1990-03-01 00:00:00














  • Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    abstract::Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation between them early in the disease process is unclear. Therefore, to investigate very early-stage changes, we compared 158 healthy midlife adult...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Low A,Su L,Stefaniak JD,Mak E,Dounavi ME,Muniz-Terrera G,Ritchie K,Ritchie CW,Markus HS,O'Brien JT

    更新日期:2020-11-02 00:00:00

  • Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

    abstract::Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM

    更新日期:2007-03-01 00:00:00

  • Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.

    abstract::The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kim N,Yu L,Dawe R,Petyuk VA,Gaiteri C,De Jager PL,Schneider JA,Arfanakis K,Bennett DA

    更新日期:2019-12-01 00:00:00

  • Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.

    abstract::The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRN...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Matamala JM,Arias-Carrasco R,Sanchez C,Uhrig M,Bargsted L,Matus S,Maracaja-Coutinho V,Abarzua S,van Zundert B,Verdugo R,Manque P,Hetz C

    更新日期:2018-04-01 00:00:00

  • Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.

    abstract::Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

    更新日期:2012-05-01 00:00:00

  • Differential effects of age on motor performance in two mouse strains.

    abstract::The performance of male A/J and C57BL/6J mice from three age groups (4, 18, and 24 months) was observed in a battery of tests designed to assess age-related impairments in motor abilities. A/J mice were superior to C57BL/6J mice in tasks requiring upper body strength, such as tests of grip strength and tightrope perfo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ingram DK,London ED,Reynolds MA,Waller SB,Goodrick CL

    更新日期:1981-10-01 00:00:00

  • Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study.

    abstract::In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

    更新日期:2012-03-01 00:00:00

  • Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system.

    abstract::Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined....

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Shepherd MN,Pomicter AD,Velazco CS,Henderson SC,Dupree JL

    更新日期:2012-01-01 00:00:00

  • Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

    abstract::Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

    更新日期:2012-04-01 00:00:00

  • Prestimulus and poststimulus oscillatory activity predicts successful episodic encoding for both young and older adults.

    abstract::Healthy aging is associated with declines in episodic memory performance that are due in part to deficits in encoding. Emerging results from young adult studies suggest that the neural activity during the time preceding stimulus presentation is sensitive to episodic memory performance. It is unknown whether age-relate...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Strunk J,Duarte A

    更新日期:2019-05-01 00:00:00

  • Functional and structural aging of the speech sensorimotor neural system: functional magnetic resonance imaging evidence.

    abstract::The ability to perceive and produce speech undergoes important changes in late adulthood. The goal of the present study was to characterize functional and structural age-related differences in the cortical network that support speech perception and production, using magnetic resonance imaging, as well as the relations...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tremblay P,Dick AS,Small SL

    更新日期:2013-08-01 00:00:00

  • Beyond measurement: the pattern is the thing.

    abstract::Perhaps cognitive and brain imaging measures have been pushed almost as far as they can go in helping diagnose or understand AD. Their value may increase with the development of better models of the disease and the addition of new types of measurements to the armamentarium (e.g., eye-tracking, olfactory, and dermatogl...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Roberts E

    更新日期:1988-01-01 00:00:00

  • Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism.

    abstract::The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

    更新日期:2003-05-01 00:00:00

  • A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease.

    abstract::Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,meta分析


    authors: Chou YH,Ton That V,Sundman M

    更新日期:2020-02-01 00:00:00

  • Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging.

    abstract::The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ohm TG,Busch C,Bohl J

    更新日期:1997-07-01 00:00:00

  • Brain cholinergic dysfunction and memory in aged rats.

    abstract::Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional sta...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RT

    更新日期:1980-07-01 00:00:00

  • White matter signal abnormality quality differentiates mild cognitive impairment that converts to Alzheimer's disease from nonconverters.

    abstract::The objective of this study was to assess how longitudinal change in the quantity and quality of white matter signal abnormalities (WMSAs) contributes to the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The Mahalanobis distance of WMSA from normal-appearing white matter using T1-, T2-,...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lindemer ER,Salat DH,Smith EE,Nguyen K,Fischl B,Greve DN,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2015-09-01 00:00:00

  • Cardiovascular, sympathetic and adrenal cortical responsiveness of aged fischer-344 rats to stress.

    abstract::While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chiueh CC,Nespor SM,Rapoport SI

    更新日期:1980-01-01 00:00:00

  • Familial Alzheimer's disease: genetic analysis related to disease heterogeneity, Down syndrome and human brain evolution.

    abstract::Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Schapiro MB,Rapoport SI

    更新日期:1989-09-01 00:00:00

  • Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain.

    abstract::Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an impor...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Sims B,Powers RE,Sabina RL,Theibert AB

    更新日期:1998-09-01 00:00:00

  • Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease.

    abstract::Amyloid beta (Aβ) is implicated in Alzheimer's disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of Aβ similar to those of the 3xTg-AD mouse model of AD. Interestingly, there was no e...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Edrey YH,Medina DX,Gaczynska M,Osmulski PA,Oddo S,Caccamo A,Buffenstein R

    更新日期:2013-10-01 00:00:00

  • Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice.

    abstract::Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

    更新日期:2016-08-01 00:00:00

  • Screening of GLE1 mutations in Chinese amyotrophic lateral sclerosis patients.

    abstract::Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

    更新日期:2018-06-01 00:00:00

  • High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain.

    abstract::Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid arte...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

    更新日期:2015-12-01 00:00:00

  • Age-related learning and memory deficits in odor-reward association in rats.

    abstract::In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Roman FS,Alescio-Lautier B,Soumireu-Mourat B

    更新日期:1996-01-01 00:00:00

  • Spatio-temporal patterns of event-related potentials related to audiovisual synchrony judgments in older adults.

    abstract::Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chan YM,Pianta MJ,Bode S,McKendrick AM

    更新日期:2017-07-01 00:00:00

  • Developmental and vascular risk factors for Alzheimer's disease.

    abstract::To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-epsilon4 allele was the strongest risk factor, and with increasing survival age, the effect of...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Borenstein AR,Wu Y,Mortimer JA,Schellenberg GD,McCormick WC,Bowen JD,McCurry S,Larson EB

    更新日期:2005-03-01 00:00:00

  • Parkin absence accelerates microtubule aging in dopaminergic neurons.

    abstract::Loss-of-function caused by mutations in the parkin gene (PARK2) lead to early-onset familial Parkinson's disease. Recently, mechanistic studies proved the ability of parkin in regulating mitochondria homeostasis and microtubule (MT) stability. Looking at these systems during aging of PARK2 knockout mice, we found that...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cartelli D,Amadeo A,Calogero AM,Casagrande FVM,De Gregorio C,Gioria M,Kuzumaki N,Costa I,Sassone J,Ciammola A,Hattori N,Okano H,Goldwurm S,Roybon L,Pezzoli G,Cappelletti G

    更新日期:2018-01-01 00:00:00

  • Evaluating pathogenic dementia variants in posterior cortical atrophy.

    abstract::Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

    更新日期:2016-01-01 00:00:00

  • Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice.

    abstract::Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these tha...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Dhenain M,El Tannir El Tayara N,Wu TD,Guégan M,Volk A,Quintana C,Delatour B

    更新日期:2009-01-01 00:00:00