Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.

Abstract:

:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive material, decreases in intracellular pH (pHi) and alterations in phosphocreatine (PCr) utilization. Prenatal (late gestational) DZ exposure induced lasting, dose-related and age-related alterations in levels of TBA-reactive material and pHi. The results indicate that the prenatal chemical environment can influence cellular metabolism throughout the lifetime of the organism, and that the process of aging can in turn interact with the consequences of prenatal drug exposure.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Miranda R,Ceckler T,Guillet R,Kellogg CK

doi

10.1016/0197-4580(90)90044-z

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

117-22

issue

2

eissn

0197-4580

issn

1558-1497

pii

0197-4580(90)90044-Z

journal_volume

11

pub_type

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