Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.

abstract：:Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation between them early in the disease process is unclear. Therefore, to investigate very early-stage changes, we compared 158 healthy midlife adult...

journal_title：Neurobiology of aging

authors： Low A,Su L,Stefaniak JD,Mak E,Dounavi ME,Muniz-Terrera G,Ritchie K,Ritchie CW,Markus HS,O'Brien JT

更新日期：2020-11-02 00:00:00

abstract：:Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the ...

journal_title：Neurobiology of aging

authors： Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM

更新日期：2007-03-01 00:00:00

abstract：:The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included...

journal_title：Neurobiology of aging

authors： Kim N,Yu L,Dawe R,Petyuk VA,Gaiteri C,De Jager PL,Schneider JA,Arfanakis K,Bennett DA

更新日期：2019-12-01 00:00:00

abstract：:The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRN...

journal_title：Neurobiology of aging

authors： Matamala JM,Arias-Carrasco R,Sanchez C,Uhrig M,Bargsted L,Matus S,Maracaja-Coutinho V,Abarzua S,van Zundert B,Verdugo R,Manque P,Hetz C

更新日期：2018-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

journal_title：Neurobiology of aging

authors： Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

更新日期：2012-05-01 00:00:00

abstract：:The performance of male A/J and C57BL/6J mice from three age groups (4, 18, and 24 months) was observed in a battery of tests designed to assess age-related impairments in motor abilities. A/J mice were superior to C57BL/6J mice in tasks requiring upper body strength, such as tests of grip strength and tightrope perfo...

journal_title：Neurobiology of aging

authors： Ingram DK,London ED,Reynolds MA,Waller SB,Goodrick CL

更新日期：1981-10-01 00:00:00

abstract：:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

journal_title：Neurobiology of aging

authors： Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

更新日期：2012-03-01 00:00:00

abstract：:Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined....

journal_title：Neurobiology of aging

authors： Shepherd MN,Pomicter AD,Velazco CS,Henderson SC,Dupree JL

更新日期：2012-01-01 00:00:00

abstract：:Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

journal_title：Neurobiology of aging

authors： Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

更新日期：2012-04-01 00:00:00

abstract：:Healthy aging is associated with declines in episodic memory performance that are due in part to deficits in encoding. Emerging results from young adult studies suggest that the neural activity during the time preceding stimulus presentation is sensitive to episodic memory performance. It is unknown whether age-relate...

journal_title：Neurobiology of aging

authors： Strunk J,Duarte A

更新日期：2019-05-01 00:00:00

abstract：:The ability to perceive and produce speech undergoes important changes in late adulthood. The goal of the present study was to characterize functional and structural age-related differences in the cortical network that support speech perception and production, using magnetic resonance imaging, as well as the relations...

journal_title：Neurobiology of aging

authors： Tremblay P,Dick AS,Small SL

更新日期：2013-08-01 00:00:00

abstract：:Perhaps cognitive and brain imaging measures have been pushed almost as far as they can go in helping diagnose or understand AD. Their value may increase with the development of better models of the disease and the addition of new types of measurements to the armamentarium (e.g., eye-tracking, olfactory, and dermatogl...

journal_title：Neurobiology of aging

authors： Roberts E

更新日期：1988-01-01 00:00:00

abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

journal_title：Neurobiology of aging

authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

更新日期：2003-05-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

journal_title：Neurobiology of aging

authors： Chou YH,Ton That V,Sundman M

更新日期：2020-02-01 00:00:00

abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

journal_title：Neurobiology of aging

authors： Ohm TG,Busch C,Bohl J

更新日期：1997-07-01 00:00:00

abstract：:Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional sta...

journal_title：Neurobiology of aging

authors： Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RT

更新日期：1980-07-01 00:00:00

abstract：:The objective of this study was to assess how longitudinal change in the quantity and quality of white matter signal abnormalities (WMSAs) contributes to the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The Mahalanobis distance of WMSA from normal-appearing white matter using T1-, T2-,...

journal_title：Neurobiology of aging

authors： Lindemer ER,Salat DH,Smith EE,Nguyen K,Fischl B,Greve DN,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2015-09-01 00:00:00

abstract：:While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

journal_title：Neurobiology of aging

authors： Chiueh CC,Nespor SM,Rapoport SI

更新日期：1980-01-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00

abstract：:Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an impor...

journal_title：Neurobiology of aging

authors： Sims B,Powers RE,Sabina RL,Theibert AB

更新日期：1998-09-01 00:00:00

abstract：:Amyloid beta (Aβ) is implicated in Alzheimer's disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of Aβ similar to those of the 3xTg-AD mouse model of AD. Interestingly, there was no e...

journal_title：Neurobiology of aging

authors： Edrey YH,Medina DX,Gaczynska M,Osmulski PA,Oddo S,Caccamo A,Buffenstein R

更新日期：2013-10-01 00:00:00

abstract：:Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

journal_title：Neurobiology of aging

authors： Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

更新日期：2016-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

journal_title：Neurobiology of aging

authors： Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

更新日期：2018-06-01 00:00:00

abstract：:Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid arte...

journal_title：Neurobiology of aging

authors： Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

更新日期：2015-12-01 00:00:00

abstract：:In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

journal_title：Neurobiology of aging

authors： Roman FS,Alescio-Lautier B,Soumireu-Mourat B

更新日期：1996-01-01 00:00:00

abstract：:Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

journal_title：Neurobiology of aging

authors： Chan YM,Pianta MJ,Bode S,McKendrick AM

更新日期：2017-07-01 00:00:00

abstract：:To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-epsilon4 allele was the strongest risk factor, and with increasing survival age, the effect of...

journal_title：Neurobiology of aging

authors： Borenstein AR,Wu Y,Mortimer JA,Schellenberg GD,McCormick WC,Bowen JD,McCurry S,Larson EB

更新日期：2005-03-01 00:00:00

abstract：:Loss-of-function caused by mutations in the parkin gene (PARK2) lead to early-onset familial Parkinson's disease. Recently, mechanistic studies proved the ability of parkin in regulating mitochondria homeostasis and microtubule (MT) stability. Looking at these systems during aging of PARK2 knockout mice, we found that...

journal_title：Neurobiology of aging

authors： Cartelli D,Amadeo A,Calogero AM,Casagrande FVM,De Gregorio C,Gioria M,Kuzumaki N,Costa I,Sassone J,Ciammola A,Hattori N,Okano H,Goldwurm S,Roybon L,Pezzoli G,Cappelletti G

更新日期：2018-01-01 00:00:00

abstract：:Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

journal_title：Neurobiology of aging

authors： Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

更新日期：2016-01-01 00:00:00

abstract：:Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these tha...

journal_title：Neurobiology of aging

authors： Dhenain M,El Tannir El Tayara N,Wu TD,Guégan M,Volk A,Quintana C,Delatour B

更新日期：2009-01-01 00:00:00