当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > 5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion.

5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion.

Abstract：

:Age-related declines in prefrontal functions and age-related declines in prefrontal serotonin (5-HT) are documented. The effect of 5-HT on prefrontal cortex (PFC) is also documented; however, no one has examined the effect of experimental 5-HT modulation on PFC in healthy older adults. We investigated the effect of 5-HT on brain functioning in 10 women over 55 (mean=63.0+/-5.3 years) during cognitive interference inhibition (Simon task) using fMRI and acute tryptophan depletion (ATD). ATD did not affect task performance; it did affect brain function. During sham/no depletion, participants activated brain regions associated with the Simon (e.g., left inferior PFC). During ATD, there was no prefrontal but alternative posterior brain activation. ATD relative to sham reduced activity in left inferior PFC, anterior cingulate and basal ganglia but increased activity within neocerebellum and parietal lobe. In older adults, ATD modulates task-relevant brain activation for cognitive interference inhibition and is associated with an anterior-to-posterior activation shift. Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Lamar M,Cutter WJ,Rubia K,Brammer M,Daly EM,Craig MC,Cleare AJ,Murphy DG

doi

10.1016/j.neurobiolaging.2007.09.013

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

1135-46

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00385-5

journal_volume

30

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.

    abstract：:Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well 123I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alz...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.12.009

    authors： Miyagawa T,Przybelski SA,Maltais D,Min HK,Jordan L,Lesnick TG,Chen Q,Graff-Radford J,Jones D,Savica R,Knopman D,Petersen R,Kremers WK,Forsberg LK,Fields JA,Ferman TJ,Allen L,Parisi J,Reichard RR,Murray M,Dickson D

    更新日期：2020-12-15 00:00:00

  • Neurons, glia, and plasticity in normal brain aging.

    abstract：:Early manifestations of brain aging have received much less attention than the drastic degeneration of AD and MID. During nonpathological changes of normal aging, brain systems differ in the involvement of neuron loss. Spatial learning can become impaired without evidence for neuron loss, whereas eye-blink conditionin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(03)00051-4

    authors： Finch CE

    更新日期：2003-05-01 00:00:00

  • Profound regional spectral, connectivity, and network changes reflect visual deficits in posterior cortical atrophy: an EEG study.

    abstract：:Patients with posterior cortical atrophy (PCA-AD) show more severe visuospatial and perceptual deficits than those with typical AD (tAD). The aim of this study was to investigate whether functional alterations measured by electroencephalography can help understand the mechanisms that explain this clinical heterogeneit...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.07.029

    authors： Briels CT,Eertink JJ,Stam CJ,van der Flier WM,Scheltens P,Gouw AA

    更新日期：2020-12-01 00:00:00

  • Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NM...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2010.04.012

    authors： Vadakkadath Meethal S,Atwood CS

    更新日期：2012-03-01 00:00:00

  • Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

    abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.029

    authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

    更新日期：2015-01-01 00:00:00

  • Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.

    abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.08.005

    authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

    更新日期：2015-01-01 00:00:00

  • Population-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County Study.

    abstract：:Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.08.022

    authors： Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

    更新日期：2015-01-01 00:00:00

  • Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production.

    abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.04.015

    authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

    更新日期：2013-10-01 00:00:00

  • Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

    abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.038

    authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

    更新日期：2015-01-01 00:00:00

  • Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice.

    abstract：:One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (MTs) and functions associated with tau. A potential way to compensate for altered MT function is to use an MT stabilizer, such as epothilone D (EpoD). Previous studies have demonstrated im...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.09.011

    authors： Guo B,Huang Y,Gao Q,Zhou Q

    更新日期：2020-12-01 00:00:00

  • Age-related accumulation of Reelin in amyloid-like deposits.

    abstract：:Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.08.011

    authors： Knuesel I,Nyffeler M,Mormède C,Muhia M,Meyer U,Pietropaolo S,Yee BK,Pryce CR,LaFerla FM,Marighetto A,Feldon J

    更新日期：2009-05-01 00:00:00

  • Nitric oxide mediated recovery sleep is attenuated with aging.

    abstract：:Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.10.006

    authors： Rytkönen KM,Wigren HK,Kostin A,Porkka-Heiskanen T,Kalinchuk AV

    更新日期：2010-11-01 00:00:00

  • Isolation of a phosphorylated soluble tau fraction from Alzheimer's disease brain.

    abstract：:Modified forms of tau proteins are major components of the paired helical filaments (PHFs) present in Alzheimer brains. In this study, tau from cytosolic samples obtained from normal and Alzheimer disease brains were fractionated by iron-chelated affinity chromatography (ICAC) to discriminate between isoforms phosphor...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(95)00075-p

    authors： Ledesma MD,Avila J,Correas I

    更新日期：1995-07-01 00:00:00

  • Comprehensive targeted next-generation sequencing in Japanese familial amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.01.004

    authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

    更新日期：2017-05-01 00:00:00

  • Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to degeneration of motor neurons. Studies suggest that in ALS axonal dysfunction precedes the death of motor neurons. Pathologically, ALS is characterized by neurofilamentous swellings (spheroids) within the axons of motor neu...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.04.004

    authors： King AE,Dickson TC,Blizzard CA,Woodhouse A,Foster SS,Chung RS,Vickers JC

    更新日期：2011-03-01 00:00:00

  • Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years.

    abstract：:We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early-stage Alzheimer's disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy, and dementia progression. Individuals with early-stage AD (n = 37) and without dementia (...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.03.016

    authors： Vidoni ED,Honea RA,Billinger SA,Swerdlow RH,Burns JM

    更新日期：2012-08-01 00:00:00

  • Sleep apnea and nocturnal myoclonus in the elderly.

    abstract：:Insomnia, daytime sleepiness, and nocturnal wandering, so common in the elderly, are caused largely by two specific pathophysiologic processes. Sleep apnea is a condition where respiration pauses during sleep, leading to arousal. Sleep apnea is due either to obstruction in the throat or failure of the central respirat...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(82)90021-5

    authors： Kripke DF,Ancoli-Israel S,Okudaira N

    更新日期：1982-01-01 00:00:00

  • Premorbid effects of APOE on synaptic proteins in human temporal neocortex.

    abstract：:APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences synaptogenesis. We measured the concentration of two presynaptic proteins, synaptophysin and syntaxin 1, and also postsynaptic density-95 (PSD95), in superior temporal co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.04.008

    authors： Love S,Siew LK,Dawbarn D,Wilcock GK,Ben-Shlomo Y,Allen SJ

    更新日期：2006-06-01 00:00:00

  • Markers of cholesterol transport are associated with amyloid deposition in the brain.

    abstract：:Cholesterol is implicated in the development of late-onset Alzheimer's disease (AD). We sought to determine the associations between beta amyloid (Aβ) plaque deposition in vivo using Pittsburgh compound B (PiB) and several indices of cholesterol homeostasis (i.e., total cholesterol, high-density lipoprotein cholestero...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.09.040

    authors： Hughes TM,Lopez OL,Evans RW,Kamboh MI,Williamson JD,Klunk WE,Mathis CA,Price JC,Cohen AD,Snitz BE,Dekosky ST,Kuller LH

    更新日期：2014-04-01 00:00:00

  • Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease.

    abstract：:In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The aim of this study was to identify a particular immune profile in the peripheral blood (PB) and cerebrospinal fluid (CSF) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and its potential...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.08.008

    authors： Lueg G,Gross CC,Lohmann H,Johnen A,Kemmling A,Deppe M,Groger J,Minnerup J,Wiendl H,Meuth SG,Duning T

    更新日期：2015-01-01 00:00:00

  • Analysis of C9orf72 in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Argentina.

    abstract：:Pathologic expansion of the G4C2 repeat in C9orf72 is the main genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To evaluate the frequency of the G4C2 expansion in a Latin American cohort of FTD and ALS patients, we used a 2-step genotyping strategy. For FTD, we observed an overal...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.02.001

    authors： Itzcovich T,Xi Z,Martinetto H,Chrem-Méndez P,Russo MJ,de Ambrosi B,Uchitel OD,Nogués M,Silva E,Rojas G,Bagnatti P,Amengual A,Campos J,Rogaeva E,St George-Hyslop P,Allegri R,Sevlever G,Surace EI

    更新日期：2016-04-01 00:00:00

  • Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: a study from India.

    abstract：:Glycogen synthase kinase-3β (GSK3B) and cyclin-dependent kinase 5 (CDK5) are the 2 major protein kinases involved in abnormal phosphorylation of tau. To determine their potential role in the pathogenesis of Parkinson's disease (PD) we analyzed 2 functional single nucleotide polymorphisms (SNPs) of GSK3B (rs334558 and ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.10.016

    authors： Das G,Misra AK,Das SK,Ray K,Ray J

    更新日期：2012-07-01 00:00:00

  • Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease.

    abstract：:Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography-mass spectrometry and n = 35 by nuclear magnetic resonan...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.08.001

    authors： Whiley L,Sen A,Heaton J,Proitsi P,García-Gómez D,Leung R,Smith N,Thambisetty M,Kloszewska I,Mecocci P,Soininen H,Tsolaki M,Vellas B,Lovestone S,Legido-Quigley C,AddNeuroMed Consortium.

    更新日期：2014-02-01 00:00:00

  • Beta-Amyloid peptide25-35 depresses excitatory synaptic transmission in the rat basolateral amygdala "in vitro".

    abstract：:The effects of beta-amyloid peptide25-35 on resting membrane potential, spontaneous and evoked action potential and synaptic activity have been studied in basolateral amygdaloid complex on slices obtained from adult rats. Intracellular recordings reveal that perfusion with beta-amyloid peptide25-35 at concentrations o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.05.008

    authors： Ashenafi S,Fuente A,Criado JM,Riolobos AS,Heredia M,Yajeya J

    更新日期：2005-04-01 00:00:00

  • Divergent brain network connectivity in amyotrophic lateral sclerosis.

    abstract：:Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional connectivity and executive fun...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.04.015

    authors： Agosta F,Canu E,Valsasina P,Riva N,Prelle A,Comi G,Filippi M

    更新日期：2013-02-01 00:00:00

  • Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease-related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence.

    abstract：:At early stages of Alzheimer's disease (AD), soluble amyloid beta (Aβ) accumulates in brain while microglia are in resting state. Microglia can recognize Aβ long after formation of plaques and release neurotoxic mediators. We examined impact of early minor activation of microglia by Toll-like receptors (TLRs) 2 and 4 ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.06.020

    authors： Pourbadie HG,Sayyah M,Khoshkholgh-Sima B,Choopani S,Nategh M,Motamedi F,Shokrgozar MA

    更新日期：2018-10-01 00:00:00

  • Profiling of endogenous brain peptides and small proteins: methodology, computer-assisted analysis, and application to aging and lesion models.

    abstract：:Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced the study of the posttranslational life of proteins. The protocol described here examined large numbers of tissue-derived peptides and small proteins, extracted i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90087-e

    authors： Slemmon JR,Flood DG

    更新日期：1992-11-01 00:00:00

  • Infrastructure for research on aging rodents: need for regional facilities to support transgenic studies on aging.

    abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(99)00007-x

    authors： Finch CE

    更新日期：1999-03-01 00:00:00

  • Voxel-based morphometry in autopsy proven PSP and CBD.

    abstract：:The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.09.019

    authors： Josephs KA,Whitwell JL,Dickson DW,Boeve BF,Knopman DS,Petersen RC,Parisi JE,Jack CR Jr

    更新日期：2008-02-01 00:00:00

  • Effects of aging on learned suppression of photopositive tendencies in Drosophila melanogaster.

    abstract：:The effect of aging on acquisition of a learned suppression of photopositive tendencies was studied in 1-7-week-old flies of both sexes. Flies had to choose in a T-maze between an alley leading to a lighted vial associated with an aversive stimulus, a quinine hydrochloride solution, and another alley leading to a dark...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2003.12.004

    authors： Le Bourg E

    更新日期：2004-10-01 00:00:00