Abstract：
:Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography-mass spectrometry and n = 35 by nuclear magnetic resonance) was developed, which enabled the comprehensive analysis of plasma from 3 groups (individuals with AD, individuals with mild cognitive impairment (MCI), and age-matched controls). This screen identified 3 phosphatidylcholine (PC) molecules that were significantly diminished in AD cases. In a subsequent validation study (n = 141), PC variation in a bigger sample set was investigated, and the same 3 PCs were found to be significantly lower in AD patients: PC 16:0/20:5 (p < 0.001), 16:0/22:6 (p < 0.05), and 18:0/22:6 (p < 0.01). A receiver operating characteristic (ROC) analysis of the PCs, combined with apolipoprotein E (ApoE) data, produced an area under the curve predictive value of 0.828. Confirmatory investigations into the background biochemistry indiciated no significant change in plasma levels of 3 additional PCs of similar structure, total choline containing compounds or total plasma omega fatty acids, adding to the evidence that specific PCs play a role in AD pathology.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Whiley L,Sen A,Heaton J,Proitsi P,García-Gómez D,Leung R,Smith N,Thambisetty M,Kloszewska I,Mecocci P,Soininen H,Tsolaki M,Vellas B,Lovestone S,Legido-Quigley C,AddNeuroMed Consortium.doi
10.1016/j.neurobiolaging.2013.08.001subject
Has Abstractpub_date
2014-02-01 00:00:00pages
271-8issue
2eissn
0197-4580issn
1558-1497pii
S0197-4580(13)00335-7journal_volume
35pub_type
杂志文章abstract：:A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, ag...
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