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Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older.

Abstract：

:Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we investigated the role of change in white matter microstructure in the activities-cognition link. We used repeated assessments of engagement, perceptual speed, and white matter microstructure (probed with diffusion tensor imaging) in a population-based sample of individuals over 80 years without dementia (n = 442, Mage = 85.1; n = 70 for diffusion tensor imaging; 2 occasions 3 years apart). Using multivariate latent change modeling, we observed positive correlations among changes in predominantly social activities, white matter microstructure, and perceptual speed. Interindividual differences in change in white matter microstructure statistically accounted for the association between change in leisure activities and change in perceptual speed. However, as analyses are based on observational data from 2 measurement occasions, causality remains unclear.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Köhncke Y,Laukka EJ,Brehmer Y,Kalpouzos G,Li TQ,Fratiglioni L,Bäckman L,Lövdén M

doi

10.1016/j.neurobiolaging.2016.02.013

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

173-186

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(16)00168-8

journal_volume

41

pub_type

杂志文章

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