Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

Abstract:

:Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysis to quantify the strength of functional connectivity between hubs of the default mode network and a network of medial temporal regions relevant for memory. Our results indicated neither memory performance nor network connectivity differed by AMD status. However, the AMD participants exhibited stronger relationships than the controls between memory performance and connectivity from the memory network hub (left parahippocampal) to 2 other regions: the left temporal pole and the right superior/middle frontal gyri. Also, the connectivity between the medial prefrontal cortex and posterior cingulate cortex of default mode network correlated more strongly with memory performance in AMD compared to control. We concluded that stronger brain-behavior correlation in AMD may suggest a role for region-specific connectivity in supporting memory in the context of AMD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Zuo X,Zhuang J,Chen NK,Cousins S,Cunha P,Lad EM,Madden DJ,Potter G,Whitson HE

doi

10.1016/j.neurobiolaging.2020.07.020

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

176-185

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(20)30237-2

journal_volume

95

pub_type

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