The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

journal_title：Neurobiology of aging

authors： Peters A,Nigro NJ,McNally KJ

更新日期：1997-01-01 00:00:00

abstract：:Overproduction of amyloid precursor protein (APP) and beta-amyloid likely contribute to neurodegeneration in Alzheimer's disease (AD). In an effort to understand neuronal APP gene regulation, we identified a 52 base element (52sce) immediately downstream from the stop codon that stabilizes APP mRNA. Deletion of this d...

journal_title：Neurobiology of aging

authors： Westmark PR,Shin HC,Westmark CJ,Soltaninassab SR,Reinke EK,Malter JS

更新日期：2006-06-01 00:00:00

abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

journal_title：Neurobiology of aging

authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

更新日期：2001-01-01 00:00:00

abstract：:Supporting the hypothesis that proteasome dysfunction is involved in Parkinson's disease (PD), McNaught et al. (2004) reported that the systemic administration of the proteasome inhibitor Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde (PSI) in rats led to the degeneration of the nigrostriatal pathway. However, several groups could ...

journal_title：Neurobiology of aging

authors： Shin M,Jan C,Jacquard C,Jarraya B,Callebert J,Launay JM,Hantraye P,Remy P,Palfi S,Brouillet E

更新日期：2011-11-01 00:00:00

abstract：:Genetic variants are implicated in the development of amyotrophic lateral sclerosis (ALS), but it is unclear whether the burden of rare variants in ALS genes has an effect on survival. We performed whole genome sequencing on 8 familial ALS (FALS) patients with superoxide dismutase 1 (SOD1) mutation and whole exome seq...

journal_title：Neurobiology of aging

authors： Pang SY,Hsu JS,Teo KC,Li Y,Kung MHW,Cheah KSE,Chan D,Cheung KMC,Li M,Sham PC,Ho SL

更新日期：2017-10-01 00:00:00

abstract：:The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining cognitive function. Damage to brain white matter putatively contributes to age-related cognitive decline. There is a growing interest in animal models from which the mechanistic basis of white matter pathology ...

journal_title：Neurobiology of aging

authors： Coltman R,Spain A,Tsenkina Y,Fowler JH,Smith J,Scullion G,Allerhand M,Scott F,Kalaria RN,Ihara M,Daumas S,Deary IJ,Wood E,McCulloch J,Horsburgh K

更新日期：2011-12-01 00:00:00

abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...

journal_title：Neurobiology of aging

authors： Chen L,Na R,Ran Q

更新日期：2014-11-01 00:00:00

abstract：:Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activation revealed that AICD overexpression was specifically associated w...

journal_title：Neurobiology of aging

authors： Kögel D,Concannon CG,Müller T,König H,Bonner C,Poeschel S,Chang S,Egensperger R,Prehn JH

更新日期：2012-09-01 00:00:00

abstract：:The effect of aging on exploratory behavior was investigated in adult (5 month) and aged (28 month) CB6F1 mice. During the first 10 minutes of the test session, aged mice made fewer head dip responses and spent less time exploring the novel stimuli. Because the aged mice were observed to subsequently increase their du...

journal_title：Neurobiology of aging

authors： Brennan MJ,Dallob A,Friedman E

更新日期：1981-10-01 00:00:00

abstract：:Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and su...

journal_title：Neurobiology of aging

authors： Fugistier P,Vallet PG,Leuba G,Piotton F,Marin P,Bouras C,Savioz A

更新日期：2014-02-01 00:00:00

abstract：:The available published guidelines for the housing of rodents are reviewed, and assessments are made with regard to whether the data on which these guidelines are based appear to be sound. Ambient air temperature, relative humidity, lighting levels and photoperiods, sound levels, cage sizes, and ventilation rates are ...

journal_title：Neurobiology of aging

authors： Clough G

更新日期：1991-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

journal_title：Neurobiology of aging

authors： Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

更新日期：2018-06-01 00:00:00

abstract：:While cytoskeletal abnormalities are prominent in the neurons of patients with Alzheimer's disease, the possibility remains that these changes are secondary to changes in the neuronal environment. The success of NGF in the therapy of Alzheimer's disease may be dependent on its ability to promote neuronal survival rath...

journal_title：Neurobiology of aging

authors： Shelanski ML

更新日期：1989-09-01 00:00:00

abstract：:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons...

journal_title：Neurobiology of aging

authors： Das MM,Svendsen CN

更新日期：2015-02-01 00:00:00

abstract：:The objective of this study was to examine the distribution and severity of tau-PET binding in cognitively normal adults with preclinical Alzheimer's disease as determined by positive beta-amyloid PET. 18F-AV-1451 tau-PET data from 109 cognitively normal older adults were processed with 34 cortical and 9 subcortical F...

journal_title：Neurobiology of aging

authors： Schultz SA,Gordon BA,Mishra S,Su Y,Perrin RJ,Cairns NJ,Morris JC,Ances BM,Benzinger TLS

更新日期：2018-12-01 00:00:00

abstract：:Parkinson's disease (PD) and Alzheimer's dementia (AD) are often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredictable. In order to assess the autonomic cardiovascular regulation baroreflex sensitivity (BRS) was determined non-invasively in 23 patient...

journal_title：Neurobiology of aging

authors： Szili-Török T,Kálmán J,Paprika D,Dibó G,Rózsa Z,Rudas L

更新日期：2001-05-01 00:00:00

abstract：:This study examined the progression of sleep-disordered breathing (SDB) over 1 year in two samples of elderly subjects: 45 healthy controls (20 men; 25 women mean age 74.8 years) and 27 recently spousally bereaved elders (9 men; 18 women, mean age 69.7 years). Although controls and bereaved subjects did not differ in ...

journal_title：Neurobiology of aging

authors： Hoch CC,Reynolds CF 3rd,Buysse DJ,Machen M,Schlernitzauer M,Hall F,Kupfer DJ

更新日期：1992-11-01 00:00:00

abstract：:The goals were to investigate implicit learning in mild cognitive impairment (MCI), and to determine the relations of implicit learning systems to apolipoprotein E (ApoE) genotype in healthy controls. Elderly controls grouped by ApoE status (ApoE-e4 allele carriers versus ApoE-e4 allele non-carriers) and MCI patients ...

journal_title：Neurobiology of aging

authors： Negash S,Petersen LE,Geda YE,Knopman DS,Boeve BF,Smith GE,Ivnik RJ,Howard DV,Howard JH Jr,Petersen RC

更新日期：2007-06-01 00:00:00

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:Amyloid beta (A beta) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human A beta induces humoral immunity, however, the immune response to endogenous rodent A beta is unknown. Fourteen-month J20 APP-tg mice and non-tg littermates were immunized subcutaneously followed by chronic intranasal ...

journal_title：Neurobiology of aging

authors： Seabrook TJ,Bloom JK,Iglesias M,Spooner ET,Walsh DM,Lemere CA

更新日期：2004-10-01 00:00:00

abstract：:We have analyzed the impact of Parkinson's disease (PD)-related genetic variants on splicing using dedicated minigene assays. Out of 14 putative splicing variants in 5 genes (PINK1, [PTEN induced kinase 1]; LRPPRC, [leucine-rich pentatricopeptide repeat containing protein]; TFAM, [mitochondrial transcription factor A]...

journal_title：Neurobiology of aging

authors： Gaweda-Walerych K,Mohagheghi F,Zekanowski C,Buratti E

更新日期：2016-11-01 00:00:00

abstract：:Exercise has emerged as a powerful variable that can improve cognitive function and delay age-associated cognitive decline and Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. To determine if protective mechanisms may occur at the transcriptional level, we used microarrays to investi...

journal_title：Neurobiology of aging

authors： Berchtold NC,Prieto GA,Phelan M,Gillen DL,Baldi P,Bennett DA,Buchman AS,Cotman CW

更新日期：2019-06-01 00:00:00

abstract：:The injection of aluminum powder into the cerebrospinal fluid of adult rabbits induced a slowly progressing encephalomyelopathy characterized at first by alteration of posture and then by myoclonic jerks and muscle weakness. Neurofibrillary degeneration was the hallmark of the disease and involved most of the gray are...

journal_title：Neurobiology of aging

authors： Bugiani O,Ghetti B

更新日期：1982-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease involving motor neurons. Because a growing number of genes have been identified as the genetic etiology of ALS, simultaneous screening of mutations in multiple genes is likely to be more efficient than gene-by-gene testing. In this ...

journal_title：Neurobiology of aging

authors： Kim HJ,Oh KW,Kwon MJ,Oh SI,Park JS,Kim YE,Choi BO,Lee S,Ki CS,Kim SH

更新日期：2016-01-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:Threshold and suprathreshold sensitivities to 13 bitter compounds were determined for 16 young adults (mean age = 27.4 years) and 18 elderly persons (mean age = 81.3 years). Half of the subjects in each age group were tasters of the bitter compound phenylthiocarbamide (PTC) and half were nontasters. Both detection and...

journal_title：Neurobiology of aging

authors： Schiffman SS,Gatlin LA,Frey AE,Heiman SA,Stagner WC,Cooper DC

更新日期：1994-11-01 00:00:00

abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

journal_title：Neurobiology of aging

authors： Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

更新日期：2016-08-01 00:00:00

abstract：:We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studie...

journal_title：Neurobiology of aging

authors： Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

更新日期：2020-04-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00