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Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer's disease.

Abstract：

:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a wide variability in values among both patients and controls was found, as well as fluctuations in repeated samples from individual patients. This suggests that several unknown factors influence the lumbar CSF levels of monoamine metabolites. The AD group showed significantly lower mean levels of HVA (p less than 0.0001) and 5-HIAA (p less than 0.0001) than the control group. A relation between severity of disease and HVA was also found. The widespread neurotransmitter disturbance in AD, together with the nonspecificity of reduced lumbar HVA and 5-HIAA levels, suggests that the changes are nonspecific, secondary to the cerebral degeneration in AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

doi

10.1016/0197-4580(92)90017-r

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

107-13

issue

1

eissn

0197-4580

issn

1558-1497

pii

0197-4580(92)90017-R

journal_volume

13

pub_type

杂志文章

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