Abstract:
:An age-related phosphorylation of the 200kD neurofilament protein (NF200) has been observed in the axons of cerebellar basket cells of normal human fixed brain tissue from individuals older than 60 years, but not in younger individuals. The probe for this study was the monoclonal antibody SMI-34 which detects a phosphorylated epitope on NF200 which appears to be different from the more frequent NF200 phosphorylated epitope found by another monoclonal antibody, SMI-31. The SMI-31 epitope was detected in our specimens at all ages examined. In sections of brainstems from normal individuals older than 52 years, from Alzheimer's disease individuals older than 65 years and from older Down's syndrome individuals (greater than 56 years) certain axons in the medial longitudinal fasciculus and in the mesencephalic trigeminal tract react positively with SMI-34, the antibody which detects the "age-related" phosphorylation epitope. All our Alzheimer's disease specimens and all our Down's syndrome specimens, even the younger ones, show staining of these fibers with SMI-31. The biochemistry of the "age-related" phosphorylation of NF200 remains to be explained.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Blanchard BJ,Ingram VMdoi
10.1016/0197-4580(89)90059-6subject
Has Abstractpub_date
1989-05-01 00:00:00pages
253-8issue
3eissn
0197-4580issn
1558-1497pii
0197-4580(89)90059-6journal_volume
10pub_type
杂志文章abstract::During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative bur...
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(89)80011-9
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章,meta分析,评审
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