Naltrexone reverses age-induced cognitive deficits in rats.

abstract：OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

journal_title：Neurobiology of aging

authors： Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

更新日期：2008-05-01 00:00:00

abstract：:An age-related phosphorylation of the 200kD neurofilament protein (NF200) has been observed in the axons of cerebellar basket cells of normal human fixed brain tissue from individuals older than 60 years, but not in younger individuals. The probe for this study was the monoclonal antibody SMI-34 which detects a phosph...

journal_title：Neurobiology of aging

authors： Blanchard BJ,Ingram VM

更新日期：1989-05-01 00:00:00

abstract：:Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease, whereas the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. Si...

journal_title：Neurobiology of aging

authors： Lancaster C,Tabet N,Rusted J

更新日期：2016-12-01 00:00:00

abstract：:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

journal_title：Neurobiology of aging

authors： Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

更新日期：2008-09-01 00:00:00

abstract：:In this study we employed an ELISA assay to measure alpha-synuclein protein in lymphomonocytes from 78 PD patients and 78 controls. We correlated protein levels with demographic and clinical characteristics and with the chymotryptic and tryptic activities of the 20S proteasome. Alpha-synuclein levels were not signific...

journal_title：Neurobiology of aging

authors： Brighina L,Prigione A,Begni B,Galbussera A,Andreoni S,Piolti R,Ferrarese C

更新日期：2010-05-01 00:00:00

abstract：:Biochemical, genetic, and epidemiological evidence indicates that inflammation is an essential part of the pathogenesis of Alzheimer's disease. Over the last decade, we and others have focused on the mechanism by which specific inflammatory molecules contribute to the Alzheimer pathogenic pathway. In particular, we ha...

journal_title：Neurobiology of aging

authors： Potter H,Wefes IM,Nilsson LN

更新日期：2001-11-01 00:00:00

abstract：:Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

journal_title：Neurobiology of aging

authors： Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

更新日期：2016-01-01 00:00:00

abstract：:In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

journal_title：Neurobiology of aging

authors： Roman FS,Alescio-Lautier B,Soumireu-Mourat B

更新日期：1996-01-01 00:00:00

abstract：:We have shown previously that the TG-3 and MPM-2 antibodies recognize phosphoepitopes common to mitosis and degenerating neurons of Alzheimer's disease(AD) brain. Here, we have evaluated their occurrence in human brain biopsy tissue, and confirm that they are absent in mature neurons of adult brain, but reappear durin...

journal_title：Neurobiology of aging

authors： Vincent I,Zheng JH,Dickson DW,Kress Y,Davies P

更新日期：1998-07-01 00:00:00

abstract：:We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar re...

journal_title：Neurobiology of aging

authors： Möller C,Hafkemeijer A,Pijnenburg YAL,Rombouts SARB,van der Grond J,Dopper E,van Swieten J,Versteeg A,Steenwijk MD,Barkhof F,Scheltens P,Vrenken H,van der Flier WM

更新日期：2016-02-01 00:00:00

abstract：:Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally infl...

journal_title：Neurobiology of aging

authors： Churchill JD,Stanis JJ,Press C,Kushelev M,Greenough WT

更新日期：2003-10-01 00:00:00

abstract：:The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second inj...

journal_title：Neurobiology of aging

authors： Bergamo M,Abílio VC,Queiroz CM,Barbosa-Júnior HN,Abdanur LR,Frussa-Filho R

更新日期：1997-11-01 00:00:00

abstract：:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

journal_title：Neurobiology of aging

authors： Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

更新日期：1992-01-01 00:00:00

abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

journal_title：Neurobiology of aging

authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

更新日期：2014-03-01 00:00:00

abstract：:Basal forebrain cholinergic neurons (BFCN), a system involved in learning and memory processes, are highly dependent on a continuous supply of biologically active nerve growth factor (NGF). Age-related cholinergic atrophy and cell loss in normal brains is apparently not complemented by reductions in the levels of NGF ...

journal_title：Neurobiology of aging

authors： Bruno MA,Cuello AC

更新日期：2012-09-01 00:00:00

abstract：:Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

journal_title：Neurobiology of aging

authors： Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

更新日期：2013-10-01 00:00:00

abstract：:To characterize the mechanisms underlying region- and age-dependent hippocampal synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing the Swedish-Indiana APP mutation. In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area bu...

journal_title：Neurobiology of aging

authors： Tozzi A,Sclip A,Tantucci M,de Iure A,Ghiglieri V,Costa C,Di Filippo M,Borsello T,Calabresi P

更新日期：2015-01-01 00:00:00

abstract：:In Pick disease and progressive supranuclear palsy (PSP), accumulations of phosphorylated tau are associated with oxidative stress, although the mechanism linking these features remains unknown. However, we suspected that the oxidative stress-induced activation of mitogen-activated protein kinases might lead to tau ph...

journal_title：Neurobiology of aging

authors： Hartzler AW,Zhu X,Siedlak SL,Castellani RJ,Avilá J,Perry G,Smith MA

更新日期：2002-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

journal_title：Neurobiology of aging

authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

更新日期：2004-11-01 00:00:00

abstract：:We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD...

journal_title：Neurobiology of aging

authors： Yoshino H,Hirano M,Stoessl AJ,Imamichi Y,Ikeda A,Li Y,Funayama M,Yamada I,Nakamura Y,Sossi V,Farrer MJ,Nishioka K,Hattori N

更新日期：2017-09-01 00:00:00

abstract：:To obtain information on the mechanisms responsible of the generation of ragged red fibers (RRF) during aging, we analyzed the mitochondrial genotype of single skeletal muscle fibers of healthy individuals having an age comprised between 45 and 92 years. The sequencing of the D-loop region showed many sequence changes...

journal_title：Neurobiology of aging

authors： Cormio A,Milella F,Vecchiet J,Felzani G,Gadaleta MN,Cantatore P

更新日期：2005-05-01 00:00:00

abstract：:We have measured several morphological parameters by electron microscopy of the frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rats 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase i...

journal_title：Neurobiology of aging

authors： Hicks P,Rolsten C,Brizzee D,Samorajski T

更新日期：1983-04-01 00:00:00

abstract：:In Parkinson disease, wild-type alpha-synuclein accumulates during aging, whereas alpha-synuclein mutations lead to an early onset and accelerated course of the disease. The generation of new neurons is decreased in regions of neurogenesis in adult mice overexpressing wild-type human alpha-synuclein. We examined the s...

journal_title：Neurobiology of aging

authors： Winner B,Rockenstein E,Lie DC,Aigner R,Mante M,Bogdahn U,Couillard-Despres S,Masliah E,Winkler J

更新日期：2008-06-01 00:00:00

abstract：:Proceptive and receptive behaviors were examined in aging and young ovariectomized female rats treated with estradiol benzoate and progesterone. Young females approached males confined in wire mesh cages more frequently and exhibited more proceptive behaviors toward these males than did middle-aged females. Both middl...

journal_title：Neurobiology of aging

authors： Chambers KC,Phoenix CH

更新日期：1986-05-01 00:00:00

abstract：:In recent years, CHCHD2 and CHCHD10 mutations were reported to be associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), although with conflicting results in different populations. The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients wi...

journal_title：Neurobiology of aging

authors： Rubino E,Brusa L,Zhang M,Boschi S,Govone F,Vacca A,Gai A,Pinessi L,Lopiano L,Rogaeva E,Rainero I

更新日期：2017-05-01 00:00:00

abstract：:The effect of aging on acquisition of a learned suppression of photopositive tendencies was studied in 1-7-week-old flies of both sexes. Flies had to choose in a T-maze between an alley leading to a lighted vial associated with an aversive stimulus, a quinine hydrochloride solution, and another alley leading to a dark...

journal_title：Neurobiology of aging

authors： Le Bourg E

更新日期：2004-10-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers m...

journal_title：Neurobiology of aging

authors： Rose C,Dorard E,Audrain M,Gorisse-Hussonnois L,Cartier N,Braudeau J,Allinquant B

更新日期：2018-01-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

journal_title：Neurobiology of aging

authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

更新日期：2017-05-01 00:00:00