Abstract:
:We have measured several morphological parameters by electron microscopy of the frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rats 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase in the fraction of endothelial cell and pericyte cytoplasmic area occupied by mitochondria in the FC, increase in the size of the pericyte mitochondria in both the FC and HC, increased capillary lumen area in the FC and decreased capillary lumen area in the HC. Also, the cytoplasmic area occupied by mitochondria in capillary pericytes is larger than in the endothelial cells of both FC and HC. These results suggest that there is regional variation in the age-associated changes in capillary morphometrics.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Hicks P,Rolsten C,Brizzee D,Samorajski Tdoi
10.1016/0197-4580(83)90057-xsubject
Has Abstractpub_date
1983-04-01 00:00:00pages
69-75issue
1eissn
0197-4580issn
1558-1497pii
0197-4580(83)90057-Xjournal_volume
4pub_type
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