Abstract：
:Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and superficial layers, were treated either with Aβ(1-42), okadaic acid, or kainic acid. Second, whole E14 and E17 embryonic cortices, and third, in vitro separated deep and superficial layers of young and old C57BL/6J mice, were treated identically. We observed that E14 and E17 neurons in culture were prone to death after the Aβ and particularly the kainic acid treatment. This was also the case for the superficial layers of the aged cortex, but not for the embryonic, the young cortex, and the deep layers of the aged cortex. Thus, the aged superficial layers appeared to be preferentially vulnerable against Aβ and kainic acid. This pattern of vulnerability corresponds to enhanced accumulation of senile plaques in the superficial cortical layers with aging and Alzheimer's disease.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Fugistier P,Vallet PG,Leuba G,Piotton F,Marin P,Bouras C,Savioz Adoi
10.1016/j.neurobiolaging.2013.08.005subject
Has Abstractpub_date
2014-02-01 00:00:00pages
322-30issue
2eissn
0197-4580issn
1558-1497pii
S0197-4580(13)00339-4journal_volume
35pub_type
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