Abstract：
:This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 age groups. Geriatric (21 months) rats performed worse on behavioral measures than young adults (12-16 weeks) and juveniles (5-6 weeks). Motor coordination and certain cognitive deficits showed age-dependence both before and after injury. Brain proteins were analyzed using silver-stained two-dimensional electrophoresis gels. Spot volume changes (>2-fold change, p<0.01) were identified between age and injury groups using computer-assisted densitometry. Sequences were determined by mass spectrometry of tryptic peptides. The 19 spots identified represented 13 different genes that fell into 4 general age- and injury-dependent expression patterns. Fifteen isoforms changed differentially with respect to both age and injury (p<0.05). Further investigations into the nature and function of these isoforms may yield insights into the vulnerability of older patients and resilience of younger patients in recovery after brain injuries.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Mehan ND,Strauss KIdoi
10.1016/j.neurobiolaging.2011.09.029subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1857-73issue
9eissn
0197-4580issn
1558-1497pii
S0197-4580(11)00381-2journal_volume
33pub_type
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journal_title：Neurobiology of aging
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2015.06.005
更新日期：2015-10-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2004.06.014
更新日期：2005-05-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2005.05.002
更新日期：2006-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/s0197-4580(88)80143-x
更新日期：1988-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2006.10.005
更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 评论,杂志文章,评审
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更新日期：2011-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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abstract：:The majority (90%-95%) of amyotrophic lateral sclerosis (ALS) is sporadic, and ∼50% of patients develop symptoms of frontotemporal degeneration (FTD) associated with shorter survival. The genetic polymorphism rs12608932 in UNC13A confers increased risk of sporadic ALS and sporadic FTD and modifies survival in ALS. Her...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
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