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Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology.

Abstract：

:The Parkinson's disease (PD)-related inclusion body pathology comprises Lewy bodies (LBs) as well as Lewy neurites (LNs). The distribution and severity of this pathology were investigated in the thalamus of 12 autopsy cases with clinically diagnosed and neuropathologically confirmed PD. The LBs and LNs were visualized by immunoreactions against the protein alpha-synuclein. In the human thalamus during PD, a specific and highly stereotypical distribution pattern of LBs and LNs evolves. As in cortical and other subcortical regions, the components of human thalamus assigned to the limbic loop bear the brunt of the PD-related pathology. In contrast, the thalamic components integrated into the striatal and cerebellar loops as well as the primary sensory nuclei of the thalamus show at best a mildly developed pathology. Damage to the thalamic components of the limbic loop nuclei may contribute not only to the cognitive, emotional, and autonomic symptoms of PD but to the somatomotor and oculomotor dysfunctions as well.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Rüb U,Del Tredici K,Schultz C,Ghebremedhin E,de Vos RA,Jansen Steur E,Braak H

doi

10.1016/s0197-4580(01)00269-x

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

245-54

issue

2

eissn

0197-4580

issn

1558-1497

pii

S019745800100269X

journal_volume

23

pub_type

杂志文章

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