Membrane disordering effect of ethanol on cerebral microvessels of aged rats: a brief report.

abstract：:Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y ...

journal_title：Neurobiology of aging

authors： Lehmann DJ,Schuur M,Warden DR,Hammond N,Belbin O,Kölsch H,Lehmann MG,Wilcock GK,Brown K,Kehoe PG,Morris CM,Barker R,Coto E,Alvarez V,Deloukas P,Mateo I,Gwilliam R,Combarros O,Arias-Vásquez A,Aulchenko YS,Ikram MA

更新日期：2012-01-01 00:00:00

abstract：:Anticholinergic drug use is common in older adults and has been related to increased dementia risk. This suggests that users of these drugs may experience accelerated cognitive decline. So far, however, longitudinal data on this topic are absent and the available evidence is inconclusive with respect to effects on spe...

journal_title：Neurobiology of aging

authors： Papenberg G,Bäckman L,Fratiglioni L,Laukka EJ,Fastbom J,Johnell K

更新日期：2017-07-01 00:00:00

abstract：:Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the ...

journal_title：Neurobiology of aging

authors： Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM

更新日期：2007-03-01 00:00:00

abstract：:The midsagittal cross-sectional dimensions of the corpus callosum, the coronal cross-sectional area of the lateral ventricles at the level of the pons, and a three-dimensional estimate of intracranial volume were derived from magnetic resonance brain images obtained from 45 monozygotic and 40 dizygotic male twin pairs...

journal_title：Neurobiology of aging

authors： Pfefferbaum A,Sullivan EV,Swan GE,Carmelli D

更新日期：2000-01-01 00:00:00

abstract：:Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence i...

journal_title：Neurobiology of aging

authors： Gros A,Wang SH

更新日期：2018-07-01 00:00:00

abstract：:Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

journal_title：Neurobiology of aging

authors： Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

更新日期：2014-09-01 00:00:00

abstract：:Synaptic density in the medial and lateral septal nuclei was examined in 3 and 24-28 months of age Fischer 344 rats. The lateral nucleus had a higher synaptic density than the medial region in both age groups. There were no statistically significant differences in synapse density in either region as a function of age,...

journal_title：Neurobiology of aging

authors： Scheff SW,Scott SA,DeKosky ST

更新日期：1991-01-01 00:00:00

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 3...

journal_title：Neurobiology of aging

authors： Wolpe N,Ingram JN,Tsvetanov KA,Henson RN,Wolpert DM,Cam-CAN.,Rowe JB

更新日期：2020-06-01 00:00:00

abstract：:Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

journal_title：Neurobiology of aging

authors： Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

更新日期：2018-02-01 00:00:00

abstract：:Distortions in the rest-activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest...

journal_title：Neurobiology of aging

authors： Oosterman J,van Harten B,Vogels R,Gouw A,Weinstein H,Scheltens P,Scherder E

更新日期：2008-08-01 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

journal_title：Neurobiology of aging

authors： Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

更新日期：2009-05-01 00:00:00

abstract：:Robust physiological circadian rhythms form an integral part of well-being. The aging process has been found to negatively impact systems that drive circadian physiology, typically manifesting as symptoms associated with abnormal/disrupted sleeping patterns. Here, we investigated the age-related decline in light-drive...

journal_title：Neurobiology of aging

authors： Biello SM,Bonsall DR,Atkinson LA,Molyneux PC,Harrington ME,Lall GS

更新日期：2018-06-01 00:00:00

abstract：:Modified forms of tau proteins are major components of the paired helical filaments (PHFs) present in Alzheimer brains. In this study, tau from cytosolic samples obtained from normal and Alzheimer disease brains were fractionated by iron-chelated affinity chromatography (ICAC) to discriminate between isoforms phosphor...

journal_title：Neurobiology of aging

authors： Ledesma MD,Avila J,Correas I

更新日期：1995-07-01 00:00:00

abstract：:Amyloid beta (A beta) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human A beta induces humoral immunity, however, the immune response to endogenous rodent A beta is unknown. Fourteen-month J20 APP-tg mice and non-tg littermates were immunized subcutaneously followed by chronic intranasal ...

journal_title：Neurobiology of aging

authors： Seabrook TJ,Bloom JK,Iglesias M,Spooner ET,Walsh DM,Lemere CA

更新日期：2004-10-01 00:00:00

abstract：:Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to el...

journal_title：Neurobiology of aging

authors： Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers R

更新日期：2012-02-01 00:00:00

abstract：:Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the olfactory pathways. Recent studies ...

journal_title：Neurobiology of aging

authors： Martel G,Simon A,Nocera S,Kalainathan S,Pidoux L,Blum D,Leclère-Turbant S,Diaz J,Geny D,Moyse E,Videau C,Buée L,Epelbaum J,Viollet C

更新日期：2015-02-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

journal_title：Neurobiology of aging

authors： Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

更新日期：2009-08-01 00:00:00

abstract：:Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeost...

journal_title：Neurobiology of aging

authors： Viola AU,Chellappa SL,Archer SN,Pugin F,Götz T,Dijk DJ,Cajochen C

更新日期：2012-05-01 00:00:00

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:In Pick disease and progressive supranuclear palsy (PSP), accumulations of phosphorylated tau are associated with oxidative stress, although the mechanism linking these features remains unknown. However, we suspected that the oxidative stress-induced activation of mitogen-activated protein kinases might lead to tau ph...

journal_title：Neurobiology of aging

authors： Hartzler AW,Zhu X,Siedlak SL,Castellani RJ,Avilá J,Perry G,Smith MA

更新日期：2002-09-01 00:00:00

abstract：:Cerebral A(1) adenosine receptors (A(1)AR) fulfill important neuromodulatory and homeostatic functions. The present study examines possible age-related A(1)AR changes in living humans by positron emission tomography (PET) and the A(1)AR ligand [(18)F]CPFPX. Thirty-six healthy volunteers aged 22-74 years were included....

journal_title：Neurobiology of aging

authors： Meyer PT,Elmenhorst D,Boy C,Winz O,Matusch A,Zilles K,Bauer A

更新日期：2007-12-01 00:00:00

abstract：:Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine da...

journal_title：Neurobiology of aging

authors： Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

更新日期：1993-01-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:Age at the time of brain injury is generally considered an important determinant in recovery of function. The implication is that older individuals show less recovery. Existing data challenge this common notion, but suggest differential effects of brain damage in aged subjects. To assess these differences old rats wer...

journal_title：Neurobiology of aging

authors： LeVere ND

更新日期：1983-10-01 00:00:00

abstract：:Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

journal_title：Neurobiology of aging

authors： Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

更新日期：2018-12-01 00:00:00

abstract：:Although the ApoE epsilon4 allele is well-established as the most important genetic risk factor for Alzheimer's disease (AD), the effects of this allele on regional brain atrophy in AD patients remain controversial. We performed MRI-based volumetric measurements of the hippocampus and amygdala (normalized to intracran...

journal_title：Neurobiology of aging

authors： Basso M,Gelernter J,Yang J,MacAvoy MG,Varma P,Bronen RA,van Dyck CH

更新日期：2006-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by an extensive loss of motor neurons in the primary motor cortex, brainstem, and spinal cord. Genetic studies report a high heritability of ALS. Recently, whole-exome sequencing analysis of familial ALS (FALS) patients allow...

journal_title：Neurobiology of aging

authors： Leblond CS,Gan-Or Z,Spiegelman D,Laurent SB,Szuto A,Hodgkinson A,Dionne-Laporte A,Provencher P,de Carvalho M,Orrù S,Brunet D,Bouchard JP,Awadalla P,Dupré N,Dion PA,Rouleau GA

更新日期：2016-01-01 00:00:00

abstract：:The retrograde response of HRP-labelled intercostal motoneurons was compared in adult (1-2 years) and aging (10-15 years) cats, 64-68 days following crush of intercostal nerves or following nerve transection with proximal ligation. A comparison of the neuroglial response to these two lesions was also made. In both adu...

journal_title：Neurobiology of aging

authors： Johnson IP,Sears TA,Hunter AS

更新日期：1991-03-01 00:00:00