Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

abstract：:Insomnia, daytime sleepiness, and nocturnal wandering, so common in the elderly, are caused largely by two specific pathophysiologic processes. Sleep apnea is a condition where respiration pauses during sleep, leading to arousal. Sleep apnea is due either to obstruction in the throat or failure of the central respirat...

journal_title：Neurobiology of aging

authors： Kripke DF,Ancoli-Israel S,Okudaira N

更新日期：1982-01-01 00:00:00

abstract：:Kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) play a key role in relaying the positive feedback effects of estradiol that activate gonadotropin-releasing hormone (GnRH) neurons and drive a surge in the GnRH/luteinizing hormone (LH) level. However, the precise role of kisspeptin n...

journal_title：Neurobiology of aging

authors： Zhang J,Yang L,Lin N,Pan X,Zhu Y,Chen X

更新日期：2014-03-01 00:00:00

abstract：:Differential cell death is a common feature of aging and age-related disease. In the retina, 30% of rod photoreceptors are lost over life in humans and rodents. However, studies have failed to show age-related cell death in mouse cone photoreceptors, which is surprising because cone physiological function declines wit...

journal_title：Neurobiology of aging

authors： Cunea A,Powner MB,Jeffery G

更新日期：2014-11-01 00:00:00

abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

journal_title：Neurobiology of aging

authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

更新日期：2007-09-01 00:00:00

abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

journal_title：Neurobiology of aging

authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

更新日期：2020-11-10 00:00:00

abstract：:Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We invest...

journal_title：Neurobiology of aging

authors： Nedelska Z,Ferman TJ,Boeve BF,Przybelski SA,Lesnick TG,Murray ME,Gunter JL,Senjem ML,Vemuri P,Smith GE,Geda YE,Graff-Radford J,Knopman DS,Petersen RC,Parisi JE,Dickson DW,Jack CR Jr,Kantarci K

更新日期：2015-01-01 00:00:00

abstract：:Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

journal_title：Neurobiology of aging

authors： Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

更新日期：2017-11-01 00:00:00

abstract：:Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

journal_title：Neurobiology of aging

authors： Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

更新日期：2019-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

journal_title：Neurobiology of aging

authors： Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

更新日期：2012-05-01 00:00:00

abstract：:Visual function declines with age. This deterioration results not only from changes in the optical system but also from the functional degradation of the central visual cortex. Although numerous studies have explored the mechanisms of age-related influences on vision, they have failed to acknowledge the significance o...

journal_title：Neurobiology of aging

authors： Wang X,Zhang B,Wang H,Liu J,Xu G,Zhou Y

更新日期：2019-04-01 00:00:00

abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

journal_title：Neurobiology of aging

authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

更新日期：2006-03-01 00:00:00

abstract：:We designed this study to determine whether the sexual behavior of male monkeys changes on a diurnal schedule that coincides with changes in the levels of hormones such as luteinizing hormone (LH), testosterone, estradiol, and cortisol, and whether these differences vary with age. Old (n = 8) and young (n = 8) males w...

journal_title：Neurobiology of aging

authors： Chambers KC,Resko JA,Phoenix CH

更新日期：1982-04-01 00:00:00

abstract：:The effect of aging on exploratory behavior was investigated in adult (5 month) and aged (28 month) CB6F1 mice. During the first 10 minutes of the test session, aged mice made fewer head dip responses and spent less time exploring the novel stimuli. Because the aged mice were observed to subsequently increase their du...

journal_title：Neurobiology of aging

authors： Brennan MJ,Dallob A,Friedman E

更新日期：1981-10-01 00:00:00

abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

journal_title：Neurobiology of aging

authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

更新日期：2012-05-01 00:00:00

abstract：:Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical c...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Lehr MA,Li JG,Liu-Chen LY

更新日期：2010-06-01 00:00:00

abstract：:The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to...

journal_title：Neurobiology of aging

authors： Larsson M,Hedner M,Papenberg G,Seubert J,Bäckman L,Laukka EJ

更新日期：2016-02-01 00:00:00

abstract：:To identify genes associated with frontotemporal dementia (FTD) in South-East Asia, targeted exome sequencing and C9orf72 genotyping was performed in 198 subjects (52 patients with FTD and 146 healthy controls) who were screened for mutations in 12 FTD-associated genes. We detected a homozygous TREM2 R47C mutation in ...

journal_title：Neurobiology of aging

authors： Ng ASL,Tan YJ,Yi Z,Tandiono M,Chew E,Dominguez J,Macas M,Ng E,Hameed S,Ting S,Tan EK,Foo JN,Kandiah N

更新日期：2018-08-01 00:00:00

abstract：:The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation of microglia and impairment of synaptic plasticity in the brain that eventually leads to cognitive decline. Chemokine fractalkine recep...

journal_title：Neurobiology of aging

authors： Wu J,Bie B,Yang H,Xu JJ,Brown DL,Naguib M

更新日期：2013-12-01 00:00:00

abstract：:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

journal_title：Neurobiology of aging

authors： Miranda R,Ceckler T,Guillet R,Kellogg CK

更新日期：1990-03-01 00:00:00

abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

journal_title：Neurobiology of aging

authors： Hartmann H,Velbinger K,Eckert A,Müller WE

更新日期：1996-07-01 00:00:00

abstract：:Telomere shortening is thought to contribute to premature senescence of satellite cells in Duchenne muscular dystrophy (DMD) muscle. Telomeric repeat binding factor-1 (TRF1) and poly (ADP-ribose) polymerase-1 (PARP1) are proteins known to modulate telomerase reverse transcriptase (TERT) activity, which controls telome...

journal_title：Neurobiology of aging

authors： Aguennouz M,Vita GL,Messina S,Cama A,Lanzano N,Ciranni A,Rodolico C,Di Giorgio RM,Vita G

更新日期：2011-12-01 00:00:00

abstract：:Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease. To test that hypothesis in vivo, we crossed Tg2576 mice, which express human amyloid precursor protein and develop plaques at 9 mon...

journal_title：Neurobiology of aging

authors： Rees T,Hammond PI,Soreq H,Younkin S,Brimijoin S

更新日期：2003-10-01 00:00:00

abstract：:Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene...

journal_title：Neurobiology of aging

authors： Daoud H,Dobrzeniecka S,Camu W,Meininger V,Dupré N,Dion PA,Rouleau GA

更新日期：2013-04-01 00:00:00

abstract：:Dopaminergic neurons in the substantia nigra produce dopamine for the nigrostriatal pathway that facilitates motor function. Postmortem examinations demonstrate an age-related loss of cells in the substantia nigra, with most of the cell loss focused on the dorsal substantia nigra compared with the ventral substantia n...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Spraker MB,Prodoehl J,Zhou XJ,Little DM

更新日期：2012-01-01 00:00:00

abstract：:Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells activate the unfolded protein response (UPR), a signal transduction pathway that enforces adaptive p...

journal_title：Neurobiology of aging

authors： Gerakis Y,Hetz C

更新日期：2018-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker degrees and patterns of Aβ deposition, glucose hypometabolism, and gray matter volume (GMV) reduction in 3 groups at risk of AD. In elderly...

journal_title：Neurobiology of aging

authors： Wirth M,Bejanin A,La Joie R,Arenaza-Urquijo EM,Gonneaud J,Landeau B,Perrotin A,Mézenge F,de La Sayette V,Desgranges B,Chételat G

更新日期：2018-03-01 00:00:00

abstract：:Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

journal_title：Neurobiology of aging

authors： Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

更新日期：2015-05-01 00:00:00

abstract：:In this study, the Purkinje neurons and granule neurons in the cerebellar cortex were studied in male Fischer 344 rats at 3, 9, 18, and 27 months of age. The numbers of Purkinje cells (PC) and granule cells (GC) in folia IV, VII, and X of the vermis were quantitated with the disector stereological technique. The numbe...

journal_title：Neurobiology of aging

authors： Dlugos CA,Pentney RJ

更新日期：1994-07-01 00:00:00

abstract：:Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's...

journal_title：Neurobiology of aging

authors： Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

更新日期：2018-04-01 00:00:00

abstract：:Eyeblink classical conditioning (EBCC) is impared in rabbits and humans during normal aging and severely disrupted in Alzheimer's disease (AD) and older Down's Syndrome patients (called DS/AD). To determine if older rabbit brains developed neuropathological evidence of Alzheimer-like pathology to account for impaired ...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Trojanowski JQ

更新日期：1996-03-01 00:00:00