Abstract：
:Eyeblink classical conditioning (EBCC) is impared in rabbits and humans during normal aging and severely disrupted in Alzheimer's disease (AD) and older Down's Syndrome patients (called DS/AD). To determine if older rabbit brains developed neuropathological evidence of Alzheimer-like pathology to account for impaired EBCC, the cerebellum and hippocampus of behaviorally tested rabbits aged 3 months to 7 years were probed using immunohistochemical techniques. Significant cell loss and gliosis were observed in some brain regions, but there was little or no deposition of beta-amyloid (A beta) or abnormal tau accumulations in telencephalic neurons, even in rabbits over 7 years of age. Our aims here are to: 1) report the results of our search for Alzheimer-like neuropathology in aged rabbit brains; and 2) highlight similarities in the brain mechanisms for EBCC between rabbits and humans and, hence, the utility of studies of EBCC in rabbits as a model system for testing cognition-enhancing drugs.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Woodruff-Pak DS,Trojanowski JQdoi
10.1016/0197-4580(95)02064-0subject
Has Abstractpub_date
1996-03-01 00:00:00pages
283-90issue
2eissn
0197-4580issn
1558-1497pii
0197458095020640journal_volume
17pub_type
杂志文章,评审abstract：:Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired...
journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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更新日期：1982-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2010.06.015
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(95)02030-6
更新日期：1996-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2018.07.001
更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2013.11.026
更新日期：2014-06-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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更新日期：1996-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(92)90035-v
更新日期：1992-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2013.04.012
更新日期：2013-10-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2017.04.018
更新日期：2017-08-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/s0197-4580(02)00130-6
更新日期：2003-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(91)90073-s
更新日期：1991-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2010.10.001
更新日期：2011-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 临床试验,杂志文章
doi：10.1016/j.neurobiolaging.2004.03.003
更新日期：2005-02-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2014.03.041
更新日期：2015-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2013.07.018
更新日期：2014-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
abstract：:Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysi...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(86)90008-4
更新日期：1986-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/s0197-4580(88)80111-8
更新日期：1988-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2004.03.013
更新日期：2005-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2012.04.014
更新日期：2013-02-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(81)90004-x
更新日期：1981-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/S0197-4580(03)00093-9
更新日期：2004-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neurobiolaging.2012.09.001
更新日期：2013-04-01 00:00:00
abstract：:We assessed whether polymers of N-acetylglucosamine (GlcNAc) have any pathogenetic role in Alzheimer's disease (AD). First, by using specific dyes, we found deposits of polymers of GlcNAc in sporadic but not in familial AD. We found that neurons and microglia exposed to GlcNAc and uridine diphosphate (UDP)-GlcNAc are ...
journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2014.12.033
更新日期：2015-05-01 00:00:00
