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Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.

Abstract：

:Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength. Once proficient, rats received an ischemic lesion of the motor cortex and underwent rehabilitative training paired with VNS for 6 weeks. VNS paired with rehabilitative training significantly enhances recovery of forelimb function after lesion. Rehabilitative training without VNS results in a 34% ± 19% recovery, whereas VNS paired with rehabilitative training yields a 98% ± 8% recovery of prelesion of forelimb function. VNS does not significantly reduce lesion size. These findings demonstrate that VNS paired with rehabilitative training enhances motor recovery in aged subjects in a model of stroke and may suggest that VNS therapy may effectively translate to elderly stroke patients.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Hays SA,Ruiz A,Bethea T,Khodaparast N,Carmel JB,Rennaker RL 2nd,Kilgard MP

doi

10.1016/j.neurobiolaging.2016.03.030

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

111-8

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(16)30022-7

journal_volume

43

pub_type

杂志文章

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