Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice.

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:Cholesterol is implicated in the development of late-onset Alzheimer's disease (AD). We sought to determine the associations between beta amyloid (Aβ) plaque deposition in vivo using Pittsburgh compound B (PiB) and several indices of cholesterol homeostasis (i.e., total cholesterol, high-density lipoprotein cholestero...

journal_title：Neurobiology of aging

authors： Hughes TM,Lopez OL,Evans RW,Kamboh MI,Williamson JD,Klunk WE,Mathis CA,Price JC,Cohen AD,Snitz BE,Dekosky ST,Kuller LH

更新日期：2014-04-01 00:00:00

abstract：:Neurogenesis persists in the adult brain as a form of plasticity due to the existence of neural stem cells (NSCs). Alterations in neurogenesis have been found in transgenic Alzheimer's disease (AD) mouse models, but NSC activity and neurogenesis in sporadic AD models remains to be examined. We herein describe a remark...

journal_title：Neurobiology of aging

authors： Díaz-Moreno M,Hortigüela R,Gonçalves A,García-Carpio I,Manich G,García-Bermúdez E,Moreno-Estellés M,Eguiluz C,Vilaplana J,Pelegrí C,Vilar M,Mira H

更新日期：2013-11-01 00:00:00

abstract：:The visual processing of complex motion is impaired in Alzheimer's disease (AD). However, it is unclear whether these impairments are biased toward the motion stream or part of a general disruption of global visual processing, given some reports of impaired static form processing in AD. Here, for the first time, we di...

journal_title：Neurobiology of aging

authors： Porter G,Wattam-Bell J,Bayer A,Haworth J,Braddick O,Atkinson J,Tales A

更新日期：2017-08-01 00:00:00

abstract：:Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulating Abeta42 is subject to complement C3b-dependent adherence to comple...

journal_title：Neurobiology of aging

authors： Rogers J,Li R,Mastroeni D,Grover A,Leonard B,Ahern G,Cao P,Kolody H,Vedders L,Kolb WP,Sabbagh M

更新日期：2006-12-01 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD). However, little is known about FtMt's functions in the retina and any links to AMD. In this study, we observed age-related increase in FtMt and ...

journal_title：Neurobiology of aging

authors： Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

更新日期：2016-11-01 00:00:00

abstract：:The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples available in the world was performed. A series of 93 vCJD UK patients and 1504 UK controls were included in the discovery stage. Our best...

journal_title：Neurobiology of aging

authors： Sanchez-Juan P,Bishop MT,Aulchenko YS,Brandel JP,Rivadeneira F,Struchalin M,Lambert JC,Amouyel P,Combarros O,Sainz J,Carracedo A,Uitterlinden AG,Hofman A,Zerr I,Kretzschmar HA,Laplanche JL,Knight RS,Will RG,van Duijn

更新日期：2012-07-01 00:00:00

abstract：:Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain. Liraglutide, a novel long-lasting glucagon-like peptide 1 (GLP-1) analog, facilitates insulin signaling and shows neuroprotective properties. In the present study, we analyzed t...

journal_title：Neurobiology of aging

authors： Han WN,Hölscher C,Yuan L,Yang W,Wang XH,Wu MN,Qi JS

更新日期：2013-02-01 00:00:00

abstract：:Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

journal_title：Neurobiology of aging

authors： Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

更新日期：2018-12-01 00:00:00

abstract：:Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with TDP-43 positive pathology. Most FTLD-related GRN mutations are nonsense mutations resulting in reduced GRN expression. Nonsynonymous GR...

journal_title：Neurobiology of aging

authors： Kleinberger G,Capell A,Brouwers N,Fellerer K,Sleegers K,Cruts M,Van Broeckhoven C,Haass C

更新日期：2016-03-01 00:00:00

abstract：:Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; ...

journal_title：Neurobiology of aging

authors： Nunnemann S,Wohlschläger AM,Ilg R,Gaser C,Etgen T,Conrad B,Zimmer C,Mühlau M

更新日期：2009-01-01 00:00:00

abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

journal_title：Neurobiology of aging

authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

更新日期：2020-02-01 00:00:00

abstract：:Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

journal_title：Neurobiology of aging

authors： Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

更新日期：2019-12-01 00:00:00

abstract：:The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

journal_title：Neurobiology of aging

authors： Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

更新日期：2019-11-01 00:00:00

abstract：:Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

journal_title：Neurobiology of aging

authors： Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

更新日期：2014-09-01 00:00:00

abstract：:Raising insulin acutely in the periphery and in brain improves verbal memory. Intranasal insulin administration, which raises insulin acutely in the CNS without raising plasma insulin levels, provides an opportunity to determine whether these effects are mediated by central insulin or peripheral processes. Based on pr...

journal_title：Neurobiology of aging

authors： Reger MA,Watson GS,Frey WH 2nd,Baker LD,Cholerton B,Keeling ML,Belongia DA,Fishel MA,Plymate SR,Schellenberg GD,Cherrier MM,Craft S

更新日期：2006-03-01 00:00:00

abstract：:The C9orf72 expansion is considered a major genetic cause of familial frontotemporal dementia (FTD) in several patients' cohorts. Interestingly, C9orf72 expansion carriers, present also abundant neuronal p62-positive inclusions. Although p62/SQSTM1 mutations were initially associated with Paget disease of bone (PDB), ...

journal_title：Neurobiology of aging

authors： Almeida MR,Letra L,Pires P,Santos A,Rebelo O,Guerreiro R,van der Zee J,Van Broeckhoven C,Santana I

更新日期：2016-04-01 00:00:00

abstract：:The goal of this experiment was to determine the correlations among different behavioral and neurobiological measures in aged rats. Aged Sprague-Dawley rats were given a battery of cognitive and sensorimotor tests, followed by electrophysiological assessment of sleep and biochemical measurements of various neurotransm...

journal_title：Neurobiology of aging

authors： Markowska AL,Stone WS,Ingram DK,Reynolds J,Gold PE,Conti LH,Pontecorvo MJ,Wenk GL,Olton DS

更新日期：1989-01-01 00:00:00

abstract：:Although neuroactive steroids exert neuroprotective actions in different experimental models of neurodegenerative diseases, including those of Alzheimer's disease (AD), their relationships with aged related physiologic and pathologic brain changes remain to be clarified. In this study the levels of pregnenolone, dehyd...

journal_title：Neurobiology of aging

authors： Caruso D,Barron AM,Brown MA,Abbiati F,Carrero P,Pike CJ,Garcia-Segura LM,Melcangi RC

更新日期：2013-04-01 00:00:00

abstract：:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

journal_title：Neurobiology of aging

authors： Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1993-01-01 00:00:00

abstract：:The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object reco...

journal_title：Neurobiology of aging

authors： Francis BM,Kim J,Barakat ME,Fraenkl S,Yücel YH,Peng S,Michalski B,Fahnestock M,McLaurin J,Mount HT

更新日期：2012-03-01 00:00:00

abstract：:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the inter...

journal_title：Neurobiology of aging

authors： Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG

更新日期：2014-07-01 00:00:00

abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

journal_title：Neurobiology of aging

authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

更新日期：2019-08-01 00:00:00

abstract：:A key question for the design of clinical trials for Alzheimer's disease (AD) is whether the timing of conversion from mild cognitive impairment (MCI) to AD can be predicted. This is also an important question for the clinical management of MCI. This study aims to address this question by exploring the contribution of...

journal_title：Neurobiology of aging

authors： Tabatabaei-Jafari H,Shaw ME,Walsh E,Cherbuin N,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2019-11-01 00:00:00

abstract：:Telomere shortening is thought to contribute to premature senescence of satellite cells in Duchenne muscular dystrophy (DMD) muscle. Telomeric repeat binding factor-1 (TRF1) and poly (ADP-ribose) polymerase-1 (PARP1) are proteins known to modulate telomerase reverse transcriptase (TERT) activity, which controls telome...

journal_title：Neurobiology of aging

authors： Aguennouz M,Vita GL,Messina S,Cama A,Lanzano N,Ciranni A,Rodolico C,Di Giorgio RM,Vita G

更新日期：2011-12-01 00:00:00

abstract：:The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

journal_title：Neurobiology of aging

authors： Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

更新日期：2013-10-01 00:00:00

abstract：:Cerebral A(1) adenosine receptors (A(1)AR) fulfill important neuromodulatory and homeostatic functions. The present study examines possible age-related A(1)AR changes in living humans by positron emission tomography (PET) and the A(1)AR ligand [(18)F]CPFPX. Thirty-six healthy volunteers aged 22-74 years were included....

journal_title：Neurobiology of aging

authors： Meyer PT,Elmenhorst D,Boy C,Winz O,Matusch A,Zilles K,Bauer A

更新日期：2007-12-01 00:00:00

abstract：:The performance of male A/J and C57BL/6J mice from three age groups (4, 18, and 24 months) was observed in a battery of tests designed to assess age-related impairments in motor abilities. A/J mice were superior to C57BL/6J mice in tasks requiring upper body strength, such as tests of grip strength and tightrope perfo...

journal_title：Neurobiology of aging

authors： Ingram DK,London ED,Reynolds MA,Waller SB,Goodrick CL

更新日期：1981-10-01 00:00:00

abstract：:Middle-aged and aged rats received dorsal hippocampal lesions before performance was evaluated on the radial-arm maze. The maze task contained simultaneous spatial working memory and visually cued reference memory components. Both middle-aged and aged rats that received lesions committed more errors of both types than...

journal_title：Neurobiology of aging

authors： Ward MT,Stoelzel CR,Markus EJ

更新日期：1999-07-01 00:00:00

abstract：:Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean a...

journal_title：Neurobiology of aging

authors： Flöel A,Suttorp W,Kohl O,Kürten J,Lohmann H,Breitenstein C,Knecht S

更新日期：2012-08-01 00:00:00