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A Golgi study of hypothalamic transplants in young and old host rats.

Abstract：

:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a quantitative Golgi study of F344 embryonic anterior hypothalamic transplants into the third ventricle of young adult (5 months) and older (25 months) male F344 rats. Three months following transplantation there were no qualitative effects of host age on neuronal morphology, nor were there quantitative effects on transplant size, dendritic length or branching frequency within the transplanted tissue. These results suggest that either (a) there were no age-related changes in factors in the host brain which were sufficient to significantly affect dendritic extent or, (b) intrinsic connections or other properties within the transplant may be important in moderating the effect of the milieu of the aged brain on the transplanted tissue.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Kaplan AS,Gash DM,Flood DG,Coleman PD

doi

10.1016/0197-4580(85)90051-x

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

205-11

issue

3

eissn

0197-4580

issn

1558-1497

pii

0197-4580(85)90051-X

journal_volume

6

pub_type

杂志文章

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