Frontal white matter integrity in adults with Down syndrome with and without dementia.

Abstract:

:Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with dementia (DSAD n = 10) and age matched non-DS subjects (CTL n = 10) would show differential levels of FA and an association with scores from the Brief Praxis Test and the Severe Impairment Battery. WM integrity differences in DS compared with CTL were found predominantly in the frontal lobes. Across all DS adults, poorer Brief Praxis Test performance correlated with reduced FA in the corpus callosum as well as several association tracts, primarily within frontoparietal regions. Our results demonstrate significantly lower WM integrity in DS compared with controls, particularly in the frontal tracts. DS-related WM integrity reductions in a number of tracts were associated with poorer cognition. These preliminary results suggest that late myelinating frontal pathways may be vulnerable to aging in DS.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Powell D,Caban-Holt A,Jicha G,Robertson W,Davis R,Gold BT,Schmitt FA,Head E

doi

10.1016/j.neurobiolaging.2014.01.137

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1562-9

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(14)00159-6

journal_volume

35

pub_type

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