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Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.

Abstract：

:Overproduction of amyloid precursor protein (APP) and beta-amyloid likely contribute to neurodegeneration in Alzheimer's disease (AD). In an effort to understand neuronal APP gene regulation, we identified a 52 base element (52sce) immediately downstream from the stop codon that stabilizes APP mRNA. Deletion of this domain drastically destabilized APP mRNAs and reduced APP synthesis in vitro. Chimeric globin-APP mRNAs containing the globin coding sequence fused to the entire APP 3'-UTR, showed regulation similar to full-length APP mRNA. A variety of cytoplasmic lysates contain 52sce RNA binding activity, suggesting cis-trans interactions regulate the element's functionality. Finally, the overexpression of chimeric mRNAs, containing the GFP coding sequence and APP 3'-UTR, dramatically reduced endogenous APP steady-state levels in SH-SY5Y neuroblastoma cells and suggests a novel approach to reduce the amyloid burden in AD patients.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Westmark PR,Shin HC,Westmark CJ,Soltaninassab SR,Reinke EK,Malter JS

doi

10.1016/j.neurobiolaging.2006.03.003

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

787-96

issue

6

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(06)00088-1

journal_volume

27

pub_type

杂志文章

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