Drug induced hypothermia in adult and senescent rats.

abstract：:We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarrier...

journal_title：Neurobiology of aging

authors： Galimberti D,Fumagalli GG,Fenoglio C,Cioffi SMG,Arighi A,Serpente M,Borroni B,Padovani A,Tagliavini F,Masellis M,Tartaglia MC,van Swieten J,Meeter L,Graff C,de Mendonça A,Bocchetta M,Rohrer JD,Scarpini E,Genetic FTD I

更新日期：2018-02-01 00:00:00

abstract：:There is a large body of evidence highlighting the importance of oxidative stress in the pathogenesis of Alzheimer's disease (AD). We have previously standardised a method that can be applied to study oxidative changes in individual brain proteins by using two-dimensional oxyblots (Korolainen MA, Goldsteins G, Alafuzo...

journal_title：Neurobiology of aging

authors： Korolainen MA,Goldsteins G,Nyman TA,Alafuzoff I,Koistinaho J,Pirttilä T

更新日期：2006-01-01 00:00:00

abstract：:Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

journal_title：Neurobiology of aging

authors： Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

更新日期：2015-05-01 00:00:00

abstract：:Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

journal_title：Neurobiology of aging

authors： Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

更新日期：2018-12-01 00:00:00

abstract：:To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3β (GSK3β) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 h...

journal_title：Neurobiology of aging

authors： Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

更新日期：2011-03-01 00:00:00

abstract：:Transgenic mice expressing mutant forms of both amyloid-beta (Abeta) precursor protein (APP) and presenilin (PS) 2 develop severe brain amyloidosis and cognitive deficits, two pathological hallmarks of Alzheimer's disease (AD). One-year-old APP/PS2 mice with high brain levels of Abeta and abundant Abeta plaques show d...

journal_title：Neurobiology of aging

authors： Carro E,Trejo JL,Gerber A,Loetscher H,Torrado J,Metzger F,Torres-Aleman I

更新日期：2006-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

journal_title：Neurobiology of aging

authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

更新日期：2004-11-01 00:00:00

abstract：:Despite cognitive and physical declines, it has been suggested that older adults remain able to regulate their emotions effectively. However, whether this is true for all emotion regulation processes has not been established. We hypothesized that cognitive reappraisal, a form of emotion regulation requiring intact cog...

journal_title：Neurobiology of aging

authors： Opitz PC,Rauch LC,Terry DP,Urry HL

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

journal_title：Neurobiology of aging

authors： Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

更新日期：2020-12-09 00:00:00

abstract：:This paper reports a series of experiments that assessed learning and memory performance in aged rats from a neuropsychological perspective. Relative to young adults, old rats displayed rapid rates of forgetting, increased susceptibility to interference, and poor long-term recall of specific experiences. There were no...

journal_title：Neurobiology of aging

authors： Winocur G

更新日期：1988-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a late-onset and progressive neurodegenerative disorder characterized clinically by memory loss, impairment of other cognitive functions, and changes in behavior and personality. The overall aim of this review is to summarize recent advances in studies of AD progression and the use of anima...

journal_title：Neurobiology of aging

authors： Reddy PH,McWeeney S

更新日期：2006-08-01 00:00:00

abstract：:The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD. The brains of AD patients contain markers whose ...

journal_title：Neurobiology of aging

authors： Mandelkow EM,Mandelkow E

更新日期：1994-01-01 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytopl...

journal_title：Neurobiology of aging

authors： Rusmini P,Crippa V,Giorgetti E,Boncoraglio A,Cristofani R,Carra S,Poletti A

更新日期：2013-11-01 00:00:00

abstract：:Cell culture systems for evaluating the biological effects of the beta-amyloid protein are potentially important tools in the study of the pathogenesis of Alzheimer's disease. In this report, methodological considerations in the assessment of beta-amyloid neurotoxicity are discussed. Chronic incubation of beta 1-40 in...

journal_title：Neurobiology of aging

authors： Busciglio J,Lorenzo A,Yankner BA

更新日期：1992-09-01 00:00:00

abstract：:The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples available in the world was performed. A series of 93 vCJD UK patients and 1504 UK controls were included in the discovery stage. Our best...

journal_title：Neurobiology of aging

authors： Sanchez-Juan P,Bishop MT,Aulchenko YS,Brandel JP,Rivadeneira F,Struchalin M,Lambert JC,Amouyel P,Combarros O,Sainz J,Carracedo A,Uitterlinden AG,Hofman A,Zerr I,Kretzschmar HA,Laplanche JL,Knight RS,Will RG,van Duijn

更新日期：2012-07-01 00:00:00

abstract：:The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging. A current consensus is that in adults advancing age affects anterior brain regions disproportionately more than posterior regions; however, the mainstay of studies supporting this anterior-posterior gr...

journal_title：Neurobiology of aging

authors： Sullivan EV,Rohlfing T,Pfefferbaum A

更新日期：2010-03-01 00:00:00

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

journal_title：Neurobiology of aging

authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

更新日期：2020-11-10 00:00:00

abstract：PURPOSE:The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects. METHODS:16 C, 6 CI, and 7 D subjects of comparable age w...

journal_title：Neurobiology of aging

authors： Cardenas VA,Du AT,Hardin D,Ezekiel F,Weber P,Jagust WJ,Chui HC,Schuff N,Weiner MW

更新日期：2003-07-01 00:00:00

abstract：:Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and su...

journal_title：Neurobiology of aging

authors： Fugistier P,Vallet PG,Leuba G,Piotton F,Marin P,Bouras C,Savioz A

更新日期：2014-02-01 00:00:00

abstract：:Alzheimer's disease (AD) has been suggested to be a systemic disease, and signal transduction abnormalities have been reported in non-neuronal AD cells. We have previously quantified the protein kinase C (PKC) subtypes in AD and control brains using a two-site enzyme immunoassay (EIA), and have shown that type II PKC ...

journal_title：Neurobiology of aging

authors： Matsushima H,Shimohama S,Tanaka S,Taniguchi T,Hagiwara M,Hidaka H,Kimura J

更新日期：1994-11-01 00:00:00

abstract：:A circular-transcriptome-wide study has recently linked differential expression of circular RNAs (circRNAs) in brain tissue with Alzheimer's disease (AD). We aimed at replicating the major findings in an independent series of sporadic and familial AD. We also included cases with frontotemporal lobar degeneration (FTLD...

journal_title：Neurobiology of aging

authors： Cervera-Carles L,Dols-Icardo O,Molina-Porcel L,Alcolea D,Cervantes-Gonzalez A,Muñoz-Llahuna L,Clarimon J

更新日期：2020-08-01 00:00:00

abstract：:Cortico-striatal-thalamic network functional connectivity (FC) and its relationship with levodopa (L-dopa) were investigated in 69 patients with hemiparkinsonism (25 drug-naïve [n-PD] and 44 under stable/optimized dopaminergic treatment [t-PD]) and 27 controls. Relative to controls, n-PD patients showed an increased F...

journal_title：Neurobiology of aging

authors： Agosta F,Caso F,Stankovic I,Inuggi A,Petrovic I,Svetel M,Kostic VS,Filippi M

更新日期：2014-11-01 00:00:00

abstract：:Alzheimer's disease of early onset versus that of late onset represent different syndromes, with distinct neuropathologies. Patients with early onset disease exhibit a more severe and more widespread loss of neurons from cortical and sub-cortical regions and the neurochemical changes involve not only the cholinergic s...

journal_title：Neurobiology of aging

authors： Iversen LL

更新日期：1987-11-01 00:00:00

abstract：:An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challeng...

journal_title：Neurobiology of aging

authors： Neuner SM,Garfinkel BP,Wilmott LA,Ignatowska-Jankowska BM,Citri A,Orly J,Lu L,Overall RW,Mulligan MK,Kempermann G,Williams RW,O'Connell KM,Kaczorowski CC

更新日期：2016-10-01 00:00:00

abstract：:The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRN...

journal_title：Neurobiology of aging

authors： Matamala JM,Arias-Carrasco R,Sanchez C,Uhrig M,Bargsted L,Matus S,Maracaja-Coutinho V,Abarzua S,van Zundert B,Verdugo R,Manque P,Hetz C

更新日期：2018-04-01 00:00:00

abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

journal_title：Neurobiology of aging

authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

更新日期：2011-03-01 00:00:00

abstract：:We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early-stage Alzheimer's disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy, and dementia progression. Individuals with early-stage AD (n = 37) and without dementia (...

journal_title：Neurobiology of aging

authors： Vidoni ED,Honea RA,Billinger SA,Swerdlow RH,Burns JM

更新日期：2012-08-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. We ...

journal_title：Neurobiology of aging

authors： Ferrari R,Grassi M,Salvi E,Borroni B,Palluzzi F,Pepe D,D'Avila F,Padovani A,Archetti S,Rainero I,Rubino E,Pinessi L,Benussi L,Binetti G,Ghidoni R,Galimberti D,Scarpini E,Serpente M,Rossi G,Giaccone G,Tagliavini F

更新日期：2015-10-01 00:00:00