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GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.

Abstract：

:To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3β (GSK3β) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 haplotype was found to be significantly associated with PD, no association was detected between the intronic rs6438552 (-157 T/C) GSK3β polymorphism and PD, whereas the C/C genotype of the promoter rs334558 (-50 T/C) GSK3β polymorphism was found to exert a protective role. The C/C genotype of the rs334558 GSK3β polymorphism was also found to have an additional protective role in our MAPT H1/H1 PD subgroup. Haplotype analysis revealed that, the T-T haplotype of both GSK3β polymorphisms was over-represented in PD patients compared to controls, and this association was independent of MAPT H1 haplotype.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

doi

10.1016/j.neurobiolaging.2009.05.007

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

546.e1-5

issue

3

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(09)00169-9

journal_volume

32

pub_type

杂志文章

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