Abstract:
:Alteration of key regulatory kinases may cause aberrant protein phosphorylation and aggregation in Alzheimer's disease (AD) and Parkinson's disease (PD). In this study, we investigated expression and phosphorylation status of glycogen synthase kinase 3 (GSK-3), protein kinase B (Akt) and tau protein in peripheral blood lymphocytes of 20 AD, 25 PD patients and 20 healthy controls. GSK-3 was increased in AD and PD patients. In these latter, GSK-3 levels were positively correlated with daily L-Dopa intake. Phosphorylated Akt expression was augmented in both groups; total Akt levels were increased only in AD patients and were positively correlated with disease duration and severity. Total and phosphorylated tau were increased only in AD, with phospho-tau levels being positively correlated with levels of total tau, Akt, and disease duration. No correlations between protein levels and clinical variables were found in PD patients. Investigation of peripheral changes in the expression of specific kinases may, therefore, lead to the development of innovative biomarkers of neurodegeneration, particularly for AD.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Armentero MT,Sinforiani E,Ghezzi C,Bazzini E,Levandis G,Ambrosi G,Zangaglia R,Pacchetti C,Cereda C,Cova E,Basso E,Celi D,Martignoni E,Nappi G,Blandini Fdoi
10.1016/j.neurobiolaging.2010.01.004subject
Has Abstractpub_date
2011-12-01 00:00:00pages
2142-51issue
12eissn
0197-4580issn
1558-1497pii
S0197-4580(10)00033-3journal_volume
32pub_type
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