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Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus.

Abstract：

:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly correlated with age. By contrast, left and right temporal lobe gray matter volumes, exclusive of the hippocampal measures, each decreased with age (p < 0.01). Volumes of temporal lobe sulcal CSF and the ventricular system (temporal horns and lateral and third ventricles) significantly increased with age. Measures of verbal and nonverbal working memory showed age-related declines and were related to enlargement of the three ventricular regions, which may be indicative of age-related atrophy of the adjacent cortex but not the hippocampus, at least up to age 70 years.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

doi

10.1016/0197-4580(95)00074-o

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

591-606

issue

4

eissn

0197-4580

issn

1558-1497

pii

019745809500074O

journal_volume

16

pub_type

杂志文章

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