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Acetyl-1-carnitine. 2: Effects on learning and memory performance of aged rats in simple and complex mazes.

Abstract：

:Acetyl-1-carnitine (AC) was administered via drinking water for six months to one group (OLD-AC) of male F-344 rats beginning at 16 months of age, while another group (OLD-CON) of rats was given water only during that period. The rats were maintained on this treatment throughout behavioral testing, which began at 22 months of age. Performance of the OLD-AC and OLD-CON rats was compared to that of young control (YG-CON) rats on the following set of tasks: spontaneous alternation in the arms of a T-maze, two-choice simultaneous discrimination in the stem of a T-maze, rewarded alternation in the arms of a T-maze, spatial discrimination and reversal on a circular platform, spatial working memory in the radial 8-arm maze, long-term memory in the 14-unit T-maze, and for preference of the light or dark chamber of a two-compartment box. AC improved the long-term memory performance in the split-stem T-maze and on the circular platform but had no discernable effects on performance of aged rats in the other tasks. Possible reasons for the selectivity of this agent's action on behavior are suggested.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Barnes CA,Markowska AL,Ingram DK,Kametani H,Spangler EL,Lemken VJ,Olton DS

doi

10.1016/0197-4580(90)90110-l

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

499-506

issue

5

eissn

0197-4580

issn

1558-1497

pii

0197-4580(90)90110-L

journal_volume

11

pub_type

杂志文章

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