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Opposite patterns of age-associated changes in neurons and glial cells of the thalamus of human brain.

Abstract：

:In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The pattern of immunoreactivity was determined by surface fractal dimension and lacunarity, the size by the field area (FA) and the spatial uniformity by the uniformity index. From the normalized FA values of immunoreactivity for the four markers studied, a global parameter was defined to give an overall characterization of the age-dependent changes in the glio-neuronal networks. A significant exponential decline of the GP was observed with increasing age. This finding suggests that early in life (age<50 years) an adaptive response might be triggered, involving the glio-neuronal networks in plastic adaptive adjustments to cope with the environmental challenges and the continuous wearing off of the neuronal structures. The slow decay of the GP observed in a later phase (age>70 years) could be due to the non-trophic reserve still available.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

doi

10.1016/j.neurobiolaging.2006.12.015

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

926-36

issue

6

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00003-6

journal_volume

29

pub_type

杂志文章

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