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Age-specific transcriptional response to stroke.

Abstract：

:Increased age is a major risk factor for stroke incidence and post-ischemic mortality. To develop age-adjusted therapeutic interventions, a clear understanding of the complexity of age-related post-ischemic mechanisms is essential. Transient occlusion of the middle cerebral artery--a model that closely resembles human stroke--was used to induce cerebral infarction in mice of 4 different ages (2, 9, 15, 24 months). By using Illumina cDNA microarrays and quantitative PCR we detected a distinct age-dependent response to stroke involving 350 differentially expressed genes. Our analyses also identified 327 differentially expressed genes that responded to stroke in an age-independent manner. These genes are involved in different aspects of the inflammatory and immune response, oxidative stress, cell cycle activation and/or DNA repair, apoptosis, cytoskeleton reorganization and/or astrogliosis, synaptic plasticity and/or neurotransmission, and depressive disorders and/or dopamine-, serotonin-, GABA-signaling. In agreement with our earlier work, aged brains displayed an attenuated inflammatory and immune response (Sieber et al., 2011) and a reduced impairment of post-stroke synaptic plasticity. Our data also revealed a distinct age-related susceptibility for post-ischemic depression, the most common neuropsychiatric consequence of stroke, which has a major influence on functional outcome.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Sieber MW,Guenther M,Jaenisch N,Albrecht-Eckardt D,Kohl M,Witte OW,Frahm C

doi

10.1016/j.neurobiolaging.2014.01.012

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1744-54

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(14)00013-X

journal_volume

35

pub_type

杂志文章

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