Abstract:
:We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49-79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Kim RE,Yun CH,Thomas RJ,Oh JH,Johnson HJ,Kim S,Lee S,Seo HS,Shin Cdoi
10.1016/j.neurobiolaging.2018.04.017subject
Has Abstractpub_date
2018-09-01 00:00:00pages
48-57eissn
0197-4580issn
1558-1497pii
S0197-4580(18)30151-9journal_volume
69pub_type
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