当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.

Abstract：

:At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early neurodegeneration of the dendritic inhibitory interneurons (oriens-lacunosum moleculare, O-LM, and hilar perforant path-associated, HIPP, cells) in the hippocampus of a transgenic PS1xAPP AD model. At 6 months of age, from 22 different pre- and postsynaptic mRNA markers tested (including GABAergic, glutamatergic and cholinergic markers), only the expression of somatostatin (SOM) and NPY neuropeptides (O-LM and HIPP markers) displayed a significant decrease. Stereological cell counting demonstrated a profound diminution (50-60%) of SOM-immunopositive neurons, preceding the pyramidal cell loss in this AD model. SOM population co-expressing NPY was the most damaged cell subset. Furthermore, a linear correlation between SOM and/or NPY deficiency and Abeta content was also observed. Though the molecular mechanism of SOM neuronal loss remains to be determined, these findings might represent an early hippocampal neuropathology. Therefore, SOM and NPY neuropeptides could constitute important biomarkers to assess the efficacy of potential early AD treatments.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Ramos B,Baglietto-Vargas D,del Rio JC,Moreno-Gonzalez I,Santa-Maria C,Jimenez S,Caballero C,Lopez-Tellez JF,Khan ZU,Ruano D,Gutierrez A,Vitorica J

doi

10.1016/j.neurobiolaging.2005.09.022

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1658-72

issue

11

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(05)00290-3

journal_volume

27

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Geometric response to nerve growth factor is preserved in aged rat sensory neurons: a single-neuron culture study.

    abstract：:We previously established a single-neuron culture system to analyze the primary effects of neurotrophic factors and reported that NGF promoted neurite extension in young adult (4- to 6-month-old) rat dorsal root ganglion (DRG) neurons by promoting neurite arborization. In this study, we demonstrated that the effects o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(93)90093-q

    authors： Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A

    更新日期：1993-03-01 00:00:00

  • Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects.

    abstract：:Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.11.020

    authors： Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

    更新日期：2012-10-01 00:00:00

  • Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain.

    abstract：:Several RNA sequences were tested for age-related changes in prevalence levels in the mouse cerebral cortex, hippocampus, and cerebellum. In all three regions, there were increased levels of RNA for glial fibrillary acidic protein, an astrocyte-specific protein, by RNA gel-blot analysis and by a solution hybridization...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(91)90056-p

    authors： Goss JR,Finch CE,Morgan DG

    更新日期：1991-03-01 00:00:00

  • Morphometric analyses of Purkinje and granule cells in aging F344 rats.

    abstract：:In this study, the Purkinje neurons and granule neurons in the cerebellar cortex were studied in male Fischer 344 rats at 3, 9, 18, and 27 months of age. The numbers of Purkinje cells (PC) and granule cells (GC) in folia IV, VII, and X of the vermis were quantitated with the disector stereological technique. The numbe...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(94)90075-2

    authors： Dlugos CA,Pentney RJ

    更新日期：1994-07-01 00:00:00

  • Social housing protects against age-related working memory decline independently of physical enrichment in rats.

    abstract：:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.11.016

    authors： Templer VL,Wise TB,Heimer-McGinn VR

    更新日期：2019-03-01 00:00:00

  • Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons.

    abstract：:Mutations in the presenilin genes account for the majority of familial Alzheimer disease (FAD) cases. In the present report we demonstrated that the FAD-linked presenilin 2 mutations (PS2 M239I and T122R) alter cystatin C trafficking in mouse primary neurons reducing secretion of its glycosylated form. These mutations...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.01.007

    authors： Ghidoni R,Benussi L,Paterlini A,Missale C,Usardi A,Rossi R,Barbiero L,Spano P,Binetti G

    更新日期：2007-03-01 00:00:00

  • Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

    abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.07.014

    authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

    更新日期：2014-01-01 00:00:00

  • Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.

    abstract：:Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.03.030

    authors： Hays SA,Ruiz A,Bethea T,Khodaparast N,Carmel JB,Rennaker RL 2nd,Kilgard MP

    更新日期：2016-07-01 00:00:00

  • White matter loss in healthy ageing: a postmortem analysis.

    abstract：:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.10.015

    authors： Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

    更新日期：2009-08-01 00:00:00

  • Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.

    abstract：:As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.11.026

    authors： Jiang T,Yu JT,Zhu XC,Tan MS,Gu LZ,Zhang YD,Tan L

    更新日期：2014-06-01 00:00:00

  • Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults.

    abstract：:Transcranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.05.017

    authors： Opie GM,Hand BJ,Coxon JP,Ridding MC,Ziemann U,Semmler JG

    更新日期：2019-09-01 00:00:00

  • Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

    abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.038

    authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

    更新日期：2015-01-01 00:00:00

  • Profiling of endogenous brain peptides and small proteins: methodology, computer-assisted analysis, and application to aging and lesion models.

    abstract：:Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced the study of the posttranslational life of proteins. The protocol described here examined large numbers of tissue-derived peptides and small proteins, extracted i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90087-e

    authors： Slemmon JR,Flood DG

    更新日期：1992-11-01 00:00:00

  • Genetic analysis of NUS1 in Chinese patients with Parkinson's disease.

    abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.09.002

    authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

    更新日期：2020-02-01 00:00:00

  • Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.

    abstract：:A large number of gene products that are enriched in the striatum have ill-defined functions, although they may have key roles in age-dependent neurodegenerative diseases affecting the striatum, especially Huntington disease (HD). In the present study, we focused on Abhd11os, (called ABHD11-AS1 in human) which is a pu...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.11.014

    authors： Francelle L,Galvan L,Gaillard MC,Petit F,Bernay B,Guillermier M,Bonvento G,Dufour N,Elalouf JM,Hantraye P,Déglon N,de Chaldée M,Brouillet E

    更新日期：2015-03-01 00:00:00

  • A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

    abstract：:A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheime...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2013.01.018

    authors： Snigdha S,Milgram NW,Willis SL,Albert M,Weintraub S,Fortin NJ,Cotman CW

    更新日期：2013-07-01 00:00:00

  • Death by color: differential cone loss in the aging mouse retina.

    abstract：:Differential cell death is a common feature of aging and age-related disease. In the retina, 30% of rod photoreceptors are lost over life in humans and rodents. However, studies have failed to show age-related cell death in mouse cone photoreceptors, which is surprising because cone physiological function declines wit...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.05.012

    authors： Cunea A,Powner MB,Jeffery G

    更新日期：2014-11-01 00:00:00

  • An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats.

    abstract：:Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.05.004

    authors： Scheib JL,Höke A

    更新日期：2016-09-01 00:00:00

  • Total tau is increased, but phosphorylated tau not decreased, in cerebrospinal fluid in amyotrophic lateral sclerosis.

    abstract：:In amyotrophic lateral sclerosis (ALS), objective biomarkers are needed for early diagnosis and progression monitoring. Reduced phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) has recently been proposed to provide such a biomarker in ALS. Here, we aimed to scrutinize this notion, evaluating both p-tau and tota...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.019

    authors： Wilke C,Deuschle C,Rattay TW,Maetzler W,Synofzik M

    更新日期：2015-02-01 00:00:00

  • Agrin and microvascular damage in Alzheimer's disease.

    abstract：:Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(00)00121-4

    authors： Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

    更新日期：2000-03-01 00:00:00

  • Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).

    abstract：:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.06.021

    authors： Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

    更新日期：2016-10-01 00:00:00

  • Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

    abstract：:Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(99)00110-4

    authors： Breteler MM

    更新日期：2000-03-01 00:00:00

  • Profound regional spectral, connectivity, and network changes reflect visual deficits in posterior cortical atrophy: an EEG study.

    abstract：:Patients with posterior cortical atrophy (PCA-AD) show more severe visuospatial and perceptual deficits than those with typical AD (tAD). The aim of this study was to investigate whether functional alterations measured by electroencephalography can help understand the mechanisms that explain this clinical heterogeneit...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.07.029

    authors： Briels CT,Eertink JJ,Stam CJ,van der Flier WM,Scheltens P,Gouw AA

    更新日期：2020-12-01 00:00:00

  • The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase.

    abstract：:The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure. Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD. In addition, AD risk fact...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.07.015

    authors： Darreh-Shori T,Modiri N,Blennow K,Baza S,Kamil C,Ahmed H,Andreasen N,Nordberg A

    更新日期：2011-07-01 00:00:00

  • Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease.

    abstract：:The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the hypothesis that it is NFT-bearing neurons that are primarily responsible for the loss of function in AD. Quantitative Golgi postmortem studies from our laborator...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(95)00035-d

    authors： Callahan LM,Coleman PD

    更新日期：1995-05-01 00:00:00

  • Inter-age variability of bona fide unvaried transcripts Normalization of quantitative PCR data in ischemic stroke.

    abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.05.023

    authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

    更新日期：2010-04-01 00:00:00

  • Testing the white matter retrogenesis hypothesis of cognitive aging.

    abstract：:The retrogenesis hypothesis postulates that late-myelinated white matter fibers are most vulnerable to age- and disease-related degeneration, which in turn mediate cognitive decline. While recent evidence supports this hypothesis in the context of Alzheimer's disease, it has not been tested systematically in normal co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.06.001

    authors： Brickman AM,Meier IB,Korgaonkar MS,Provenzano FA,Grieve SM,Siedlecki KL,Wasserman BT,Williams LM,Zimmerman ME

    更新日期：2012-08-01 00:00:00

  • Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline.

    abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.05.007

    authors： Chen L,Na R,Ran Q

    更新日期：2014-11-01 00:00:00

  • Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia.

    abstract：PURPOSE:The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects. METHODS:16 C, 6 CI, and 7 D subjects of comparable age w...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00130-6

    authors： Cardenas VA,Du AT,Hardin D,Ezekiel F,Weber P,Jagust WJ,Chui HC,Schuff N,Weiner MW

    更新日期：2003-07-01 00:00:00

  • Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain.

    abstract：:Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.12.008

    authors： Verdurand M,Chauveau F,Daoust A,Morel AL,Bonnefoi F,Liger F,Bérod A,Zimmer L

    更新日期：2016-04-01 00:00:00