Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).

Abstract:

:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the cognitive decline in this long-lived animal model. We administered ANDRO to aged degus (56-month old) for 3 months. In addition, in 2 control groups (young degus: 12-month old and aged degus: 56-month old), we administrated saline solution as a vehicle. We evaluated cognitive performance through several behavioral tests. We also performed a series of physiological and biochemical analyses (e.g., electrophysiological and immunoblotting assessment) to identify possible mechanisms underlying cognitive performance associated with age. Our results suggest that there is an effect of aging on the loss of cognitive function, and this decrease in cognitive function was also related to a decrease in the synaptic functions and an increase in the main hallmarks of Alzheimer's disease (AD). More importantly, ANDRO treatments showed the following beneficial effects: (1) recovery of spatial memory and learning performance; (2) recovery of synaptic basal transmission; (3) partial or complete protection of certain synaptic proteins; and (4) a specific neuroprotective effect, including the reduction of phosphorylated tau protein and amyloid beta aggregate maturation in aged degus. Taken together, our results suggest that ANDRO could be used as a potential therapy for AD and support the use of O. degus as a natural model in which to study both neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

doi

10.1016/j.neurobiolaging.2016.06.021

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

204-20

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(16)30121-X

journal_volume

46

pub_type

杂志文章
  • Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

    abstract::There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neurobiolaging.2019.01.014

    authors: Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

    更新日期:2019-05-01 00:00:00

  • Age-related alterations in performance monitoring during and after learning.

    abstract::Changes of performance monitoring during and after learning of stimulus-response (S-R) associations were examined in younger and older adults using event-related brain potentials (ERPs). To determine whether age-related differences in performance monitoring are attenuated when learning performance is equalized between...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2009.07.016

    authors: Pietschmann M,Endrass T,Kathmann N

    更新日期:2011-07-01 00:00:00

  • Sympathetic neuroaxonal dystrophy in the aged rat pineal gland.

    abstract::Dysfunction of circadian melatonin production by the pineal gland in aged humans and rats is thought to reflect the functional loss of its sympathetic innervation. Our ultrastructural neuropathologic studies of the sympathetic innervation of the pineal gland of aged (24 months old) Fischer-344 and Sprague-Dawley rats ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2005.08.005

    authors: Schmidt RE,Dorsey DA,Parvin CA,Beaudet LN

    更新日期:2006-10-01 00:00:00

  • Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by an extensive loss of motor neurons in the primary motor cortex, brainstem, and spinal cord. Genetic studies report a high heritability of ALS. Recently, whole-exome sequencing analysis of familial ALS (FALS) patients allow...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2015.09.013

    authors: Leblond CS,Gan-Or Z,Spiegelman D,Laurent SB,Szuto A,Hodgkinson A,Dionne-Laporte A,Provencher P,de Carvalho M,Orrù S,Brunet D,Bouchard JP,Awadalla P,Dupré N,Dion PA,Rouleau GA

    更新日期:2016-01-01 00:00:00

  • Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer's disease.

    abstract::The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(92)90017-r

    authors: Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

    更新日期:1992-01-01 00:00:00

  • Sleep-disordered breathing in healthy and spousally bereaved elderly: a one-year follow-up study.

    abstract::This study examined the progression of sleep-disordered breathing (SDB) over 1 year in two samples of elderly subjects: 45 healthy controls (20 men; 25 women mean age 74.8 years) and 27 recently spousally bereaved elders (9 men; 18 women, mean age 69.7 years). Although controls and bereaved subjects did not differ in ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(92)90098-i

    authors: Hoch CC,Reynolds CF 3rd,Buysse DJ,Machen M,Schlernitzauer M,Hall F,Kupfer DJ

    更新日期:1992-11-01 00:00:00

  • beta-Amyloid (A beta) deposition in the brains of aged orangutans.

    abstract::While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(97)00012-2

    authors: Gearing M,Tigges J,Mori H,Mirra SS

    更新日期:1997-03-01 00:00:00

  • Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging.

    abstract::Dogs exhibit both neuroanatomical and cognitive changes as a function of age that parallel those seen in aging humans. This study describes in vivo changes in neuroanatomical and cerebrovascular characteristics of the canine brain as a function of age in a group of dogs ranging from 4 to 15 years old. Dynamic contrast...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(98)00081-5

    authors: Su MY,Head E,Brooks WM,Wang Z,Muggenburg BA,Adam GE,Sutherland R,Cotman CW,Nalcioglu O

    更新日期:1998-09-01 00:00:00

  • Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT.

    abstract::This study aimed to investigate cross-sectional and longitudinal changes of regional cerebral blood flow (rCBF) in preclinical dementia using single photon emission computed tomography (SPECT). SPECT and cognitive function were investigated in 39 mild cognitive impairment (MCI) subjects and 20 age-matched controls. Al...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2006.05.017

    authors: Huang C,Eidelberg D,Habeck C,Moeller J,Svensson L,Tarabula T,Julin P

    更新日期:2007-07-01 00:00:00

  • A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.

    abstract::Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Abeta1-30, which is homologous to Abeta, and allows plaque detection in vivo. microMRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTP...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2006.12.018

    authors: Sigurdsson EM,Wadghiri YZ,Mosconi L,Blind JA,Knudsen E,Asuni A,Scholtzova H,Tsui WH,Li Y,Sadowski M,Turnbull DH,de Leon MJ,Wisniewski T

    更新日期:2008-06-01 00:00:00

  • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

    abstract::The amyloid beta-peptide (A beta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal protein oxidation is a consequence of A beta-associated free radicals [8]. In this study we have used both in vitro and in vivo models of beta-amyloid (A beta) to...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(99)00056-1

    authors: Yatin SM,Varadarajan S,Link CD,Butterfield DA

    更新日期:1999-05-01 00:00:00

  • Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

    abstract::C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansio...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2016.08.023

    authors: Kun-Rodrigues C,Ross OA,Orme T,Shepherd C,Parkkinen L,Darwent L,Hernandez D,Ansorge O,Clark LN,Honig LS,Marder K,Lemstra A,Scheltens P,van der Flier W,Louwersheimer E,Holstege H,Rogaeva E,St George-Hyslop P,Londos E,

    更新日期:2017-01-01 00:00:00

  • Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging.

    abstract::An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2005.07.021

    authors: Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

    更新日期:2006-03-01 00:00:00

  • Correlation of diurnal changes in hormones with sexual behavior and age in male rhesus macaques.

    abstract::We designed this study to determine whether the sexual behavior of male monkeys changes on a diurnal schedule that coincides with changes in the levels of hormones such as luteinizing hormone (LH), testosterone, estradiol, and cortisol, and whether these differences vary with age. Old (n = 8) and young (n = 8) males w...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(82)90059-8

    authors: Chambers KC,Resko JA,Phoenix CH

    更新日期:1982-04-01 00:00:00

  • Depressed baroreflex sensitivity in patients with Alzheimer's and Parkinson's disease.

    abstract::Parkinson's disease (PD) and Alzheimer's dementia (AD) are often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredictable. In order to assess the autonomic cardiovascular regulation baroreflex sensitivity (BRS) was determined non-invasively in 23 patient...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(01)00210-x

    authors: Szili-Török T,Kálmán J,Paprika D,Dibó G,Rózsa Z,Rudas L

    更新日期:2001-05-01 00:00:00

  • Accumulation of amyloid beta protein in transgenic mice.

    abstract::Carboxyl-terminal fragments of beta amyloid precursor protein (betaAPP) were expressed in mice under the transcriptional control of an ubiquitous promoter system, based upon a chicken beta-actin (betaA) promoter combined with cytomegalovirus (CMV) enhancer to obtain a systemic overproduction of amyloid beta protein (A...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(98)00043-8

    authors: Shoji M,Kawarabayashi T,Sato M,Sasaki A,Matsubara E,Igeta Y,Kanai M,Tomidokoro Y,Shizuka M,Ishiguro K,Harigaya Y,Okamoto K,Hirai S

    更新日期:1998-01-01 00:00:00

  • Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease.

    abstract::Progranulin plays an important role in neuroinflammation in Alzheimer's disease (AD) pathophysiology, being upregulated by activated microglia. This study assessed whether cerebrospinal fluid levels of progranulin correlated with structural neuroimaging measures and cognition in 122 cognitively normal individuals, 81 ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2019.12.012

    authors: Batzu L,Westman E,Pereira JB,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2020-04-01 00:00:00

  • Changes in intraneuronal lipopigment in Alzheimer's disease.

    abstract::Brains were examined from 22 patients with Alzheimer's disease (AD) (mean age 80.5, S.D. 11.5) and were compared with brains from 20 nondiseased subjects (mean age 81.1, S.D. 10.2). Intraneuronal lipopigment in all layers of a region of the superior frontal cortex was identified by fluorescence microscopy. The areas e...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(92)90077-b

    authors: Dowson JH,Mountjoy CQ,Cairns MR,Wilton-Cox H

    更新日期:1992-07-01 00:00:00

  • Estrogen use and brain metabolic change in postmenopausal women.

    abstract:OBJECTIVE:We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study. METHOD:Women estrogen users (n = 11) and non-users (n = 9) were studied at baseline and 2 years later. Analyses focused on glucose metabolism in regions previously...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.neurobiolaging.2004.03.003

    authors: Rasgon NL,Silverman D,Siddarth P,Miller K,Ercoli LM,Elman S,Lavretsky H,Huang SC,Phelps ME,Small GW

    更新日期:2005-02-01 00:00:00

  • The effects of antioxidants in the senescent auditory cortex.

    abstract::We investigated whether a 2-month dietary supplementation of antioxidants, in the form of blueberry phytochemicals, could reverse or retard the age-related decline in temporal processing speed observed in the aged rat. To this end, extracellular single unit responses to frequency modulated (FM) sweeps were recorded in...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2005.05.003

    authors: de Rivera C,Shukitt-Hale B,Joseph JA,Mendelson JR

    更新日期:2006-07-01 00:00:00

  • Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model.

    abstract::During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative bur...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2020.04.003

    authors: Ferreiro E,Lanzillo M,Canhoto D,Carvalho da Silva AM,Mota SI,Dias IS,Ferreira IL,Fontes AR,Mastrella G,Pinheiro P,Valero J,Rego AC

    更新日期:2020-08-01 00:00:00

  • APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis.

    abstract::To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-buil...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2017.01.014

    authors: Sudre CH,Cardoso MJ,Frost C,Barnes J,Barkhof F,Fox N,Ourselin S,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-05-01 00:00:00

  • Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.

    abstract::The current study describes both Abeta and tau abnormalities that accumulate in the brains of aged (16-21 years), but not young (<4 years) clinically characterized cats. Diffuse plaques that were morphologically different from what is typically observed in the human brain could be detected with 4G8 (Abeta17-24) or an ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2004.06.015

    authors: Head E,Moffat K,Das P,Sarsoza F,Poon WW,Landsberg G,Cotman CW,Murphy MP

    更新日期:2005-05-01 00:00:00

  • Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

    abstract::Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2012.12.011

    authors: Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

    更新日期:2013-06-01 00:00:00

  • Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease.

    abstract::Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2009.07.003

    authors: Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

    更新日期:2011-07-01 00:00:00

  • Up-regulation of opiate receptors following chronic naloxone treatment in aged rats.

    abstract::The present study assessed whether there are age-dependent differences in up-regulation of opiate receptors following chronic naloxone treatment in mature (3 months) and aged (27 months) male Wistar rats. Half of each age group were implanted subdermally with slow-release naloxone pellets for 10 days, and half were gi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(89)80011-9

    authors: Neisewander JL,Nonneman AJ,McDougall SA,Bardo MT

    更新日期:1989-01-01 00:00:00

  • An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats.

    abstract::Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2016.05.004

    authors: Scheib JL,Höke A

    更新日期:2016-09-01 00:00:00

  • New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease.

    abstract::Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2009.03.004

    authors: Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

    更新日期:2011-03-01 00:00:00

  • A further evaluation of the effect of age on striate cortex of the rhesus monkey.

    abstract::The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(96)00208-4

    authors: Peters A,Nigro NJ,McNally KJ

    更新日期:1997-01-01 00:00:00

  • Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential.

    abstract::The mitochondrial theory of aging argues that oxidative stress, caused by mitochondrial DNA mutations, is associated with decreased adenosine triphosphate (ATP) production leading to cellular degeneration. The rate of this degradation is linked to metabolic demand, with the outer retina having the greatest in the body...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2012.04.014

    authors: Kokkinopoulos I,Colman A,Hogg C,Heckenlively J,Jeffery G

    更新日期:2013-02-01 00:00:00