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A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

Abstract：

:A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheimer's disease. The National Institute of Health (NIH) has led an initiative to develop a comprehensive Toolbox for Neurologic Behavioral Function (NIH Toolbox) to evaluate cognitive, motor, sensory and emotional function for use in epidemiologic and clinical studies spanning 3 to 85 years of age. This paper aims to analyze the strengths and limitations of animal behavioral tests that can be used to parallel those in the NIH Toolbox. We conclude that there are several paradigms available to define a preclinical battery that parallels the NIH Toolbox. We also suggest areas in which new tests may benefit the development of a comprehensive preclinical test battery for assessment of cognitive function in animal models of aging and Alzheimer's disease.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Snigdha S,Milgram NW,Willis SL,Albert M,Weintraub S,Fortin NJ,Cotman CW

doi

10.1016/j.neurobiolaging.2013.01.018

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1891-901

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(13)00048-1

journal_volume

34

pub_type

杂志文章,评审

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