当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.

Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.

Abstract：

:The use of biomarkers has been proposed for diagnosing Alzheimer's disease in recent criteria, but some biomarkers have not been sufficiently investigated to justify their routine clinical use. Here, we evaluate in a literature review the clinical validity of amyloid positron emission tomography (PET) imaging using a structured framework developed for the assessment of oncological biomarkers. Homogenous criteria have been addressed in reviews of other Alzheimer's disease biomarkers. There is adequate evidence that the main aims of phases 1 (rationale for use) and 2 (discriminative ability) have been achieved. The aims of phase 3 (early detection ability) have been partly achieved, while phase 4 studies (performance in representative mild cognitive impairment patients) are currently ongoing. Phase 5 studies (quantification of impact and costs) are still to come. This review highlights the priorities to be pursued to enable the proper use of amyloid PET imaging in a clinical setting. Future investigations will primarily be large, phase 4 studies that will assess the utility of amyloid PET imaging in routine clinical practice.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Chiotis K,Saint-Aubert L,Boccardi M,Gietl A,Picco A,Varrone A,Garibotto V,Herholz K,Nobili F,Nordberg A,Geneva Task Force for the Roadmap of Alzheimer's Biomarkers.

doi

10.1016/j.neurobiolaging.2016.07.012

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

214-227

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(16)30148-8

journal_volume

52

pub_type

杂志文章,评审

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Region-specific downregulation of free intracellular calcium in the aged rat brain.

    abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(96)84400-9

    authors： Hartmann H,Velbinger K,Eckert A,Müller WE

    更新日期：1996-07-01 00:00:00

  • Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.

    abstract：:Overproduction of amyloid precursor protein (APP) and beta-amyloid likely contribute to neurodegeneration in Alzheimer's disease (AD). In an effort to understand neuronal APP gene regulation, we identified a 52 base element (52sce) immediately downstream from the stop codon that stabilizes APP mRNA. Deletion of this d...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.03.003

    authors： Westmark PR,Shin HC,Westmark CJ,Soltaninassab SR,Reinke EK,Malter JS

    更新日期：2006-06-01 00:00:00

  • Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.

    abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.10.007

    authors： Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

    更新日期：2012-05-01 00:00:00

  • Effects of hypocaloric diet on sleep in young and old rats.

    abstract：:Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00030-1

    authors： Salin-Pascual RJ,Upadhyay U,Shiromani PJ

    更新日期：2002-09-01 00:00:00

  • Variation in tau isoform expression in different brain regions and disease states.

    abstract：:Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.01.017

    authors： Majounie E,Cross W,Newsway V,Dillman A,Vandrovcova J,Morris CM,Nalls MA,Ferrucci L,Owen MJ,O'Donovan MC,Cookson MR,Singleton AB,de Silva R,Morris HR

    更新日期：2013-07-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract：:Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.005

    authors： Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期：2013-05-01 00:00:00

  • N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice.

    abstract：:Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity was localized to the N-terminal res...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.006

    authors： Ou-Yang MH,Xu F,Liao MC,Davis J,Robinson JK,Van Nostrand WE

    更新日期：2015-02-01 00:00:00

  • Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging.

    abstract：:Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brai...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.10.023

    authors： McDonough IM,Madan CR

    更新日期：2020-11-14 00:00:00

  • Age-related vulnerability of pattern separation in C57BL/6J mice.

    abstract：:Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.10.013

    authors： Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

    更新日期：2018-02-01 00:00:00

  • Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.

    abstract：:The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRN...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.12.020

    authors： Matamala JM,Arias-Carrasco R,Sanchez C,Uhrig M,Bargsted L,Matus S,Maracaja-Coutinho V,Abarzua S,van Zundert B,Verdugo R,Manque P,Hetz C

    更新日期：2018-04-01 00:00:00

  • The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.

    abstract：:Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well 123I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alz...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.12.009

    authors： Miyagawa T,Przybelski SA,Maltais D,Min HK,Jordan L,Lesnick TG,Chen Q,Graff-Radford J,Jones D,Savica R,Knopman D,Petersen R,Kremers WK,Forsberg LK,Fields JA,Ferman TJ,Allen L,Parisi J,Reichard RR,Murray M,Dickson D

    更新日期：2020-12-15 00:00:00

  • A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.

    abstract：:Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.09.009

    authors： Deming Y,Xia J,Cai Y,Lord J,Holmans P,Bertelsen S,Holtzman D,Morris JC,Bales K,Pickering EH,Kauwe J,Goate A,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative (ADNI).

    更新日期：2016-01-01 00:00:00

  • Healthy aging is associated with increased neural processing of positive valence but attenuated processing of emotional arousal: an fMRI study.

    abstract：:Arousal and valence play key roles in emotional perception, with normal aging leading to changes in the neural substrates supporting valence processing. The objective of this study was to investigate normal age-related changes in the neural substrates of emotional arousal processing. Twenty-three young and 23 older, h...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.07.006

    authors： Kehoe EG,Toomey JM,Balsters JH,Bokde AL

    更新日期：2013-03-01 00:00:00

  • KIBRA gene variants are associated with episodic memory in healthy elderly.

    abstract：:The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.02.001

    authors： Schaper K,Kolsch H,Popp J,Wagner M,Jessen F

    更新日期：2008-07-01 00:00:00

  • Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain.

    abstract：:Chronic treatment (21 days) with phosphatidylserine (BC-PS) partially restored the reduced density of muscarinic cholinergic receptors in several regions of the aged (18 months) mouse brain. The effect was similar whether 3H-QNB or 3H-NMS was used as radioligand. The affinity of both radioligands was not altered by BC...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90007-k

    authors： Gelbmann CM,Müller WE

    更新日期：1992-01-01 00:00:00

  • Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.

    abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.02.028

    authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

    更新日期：2016-06-01 00:00:00

  • Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.

    abstract：:The triple transgenic mouse model (3×TgAD: APPswe, TauP301L, PS1M146V) recapitulates both amyloid β (Aβ)- and tau-related lesions as well as synaptic and memory deficits. In these mice, we reported an early apathy-like behavior and alterations in synaptic plasticity appearing concomitantly with intraneuronal accumulat...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.06.038

    authors： Bourgeois A,Lauritzen I,Lorivel T,Bauer C,Checler F,Pardossi-Piquard R

    更新日期：2018-11-01 00:00:00

  • Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis.

    abstract：:In a prospective study of dementia in Flanders (Belgium), we observed a substantial fraction of early-onset dementia patients who did not fulfill the criteria for a specific dementia subtype, leaving the patients without a precise clinical diagnosis. We selected 211 of these patients for genetic testing of causal gene...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.04.015

    authors： Perrone F,Cacace R,Van Mossevelde S,Van den Bossche T,De Deyn PP,Cras P,Engelborghs S,van der Zee J,Van Broeckhoven C

    更新日期：2018-09-01 00:00:00

  • Skewed X-chromosome inactivation and XIST locus methylation levels do not contribute to the lower prevalence of Parkinson's disease in females.

    abstract：:Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewe...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.05.021

    authors： Sharma A,Kaut O,Pavlova A,Fröhlich H,Ahmad A,Schmitt I,El-Maarri O,Oldenburg J,Wüllner U

    更新日期：2017-09-01 00:00:00

  • Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy.

    abstract：:Telomere shortening is thought to contribute to premature senescence of satellite cells in Duchenne muscular dystrophy (DMD) muscle. Telomeric repeat binding factor-1 (TRF1) and poly (ADP-ribose) polymerase-1 (PARP1) are proteins known to modulate telomerase reverse transcriptase (TERT) activity, which controls telome...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.01.008

    authors： Aguennouz M,Vita GL,Messina S,Cama A,Lanzano N,Ciranni A,Rodolico C,Di Giorgio RM,Vita G

    更新日期：2011-12-01 00:00:00

  • Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms.

    abstract：:We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD wi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.010

    authors： Babiloni C,Del Percio C,Lizio R,Noce G,Lopez S,Soricelli A,Ferri R,Pascarelli MT,Catania V,Nobili F,Arnaldi D,Famà F,Orzi F,Buttinelli C,Giubilei F,Bonanni L,Franciotti R,Onofrj M,Stirpe P,Fuhr P,Gschwandtner U,

    更新日期：2019-01-01 00:00:00

  • Neurons, glia, and plasticity in normal brain aging.

    abstract：:Early manifestations of brain aging have received much less attention than the drastic degeneration of AD and MID. During nonpathological changes of normal aging, brain systems differ in the involvement of neuron loss. Spatial learning can become impaired without evidence for neuron loss, whereas eye-blink conditionin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(03)00051-4

    authors： Finch CE

    更新日期：2003-05-01 00:00:00

  • Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus.

    abstract：:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly c...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(95)00074-o

    authors： Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

    更新日期：1995-07-01 00:00:00

  • Age-associated changes of cerebrospinal fluid amyloid-β and tau in cynomolgus monkeys.

    abstract：:Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associate...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.01.139

    authors： Yue F,Lu C,Ai Y,Chan P,Zhang Z

    更新日期：2014-07-01 00:00:00

  • L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.

    abstract：:Abnormal neuronal excitability and impaired synaptic plasticity might occur before the degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential biophysical alterations underlying aberrant neuronal network activity in AD, we performed whole-cell patch clamp analyses of L-type (nifedipine-se...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.07.007

    authors： Wang Y,Mattson MP

    更新日期：2014-01-01 00:00:00

  • Opiate receptor characteristics in brains from young, mature and aged mice.

    abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80066-6

    authors： Ueno E,Liu DD,Ho IK,Hoskins B

    更新日期：1988-05-01 00:00:00

  • The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

    abstract：:Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activation revealed that AICD overexpression was specifically associated w...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.06.012

    authors： Kögel D,Concannon CG,Müller T,König H,Bonner C,Poeschel S,Chang S,Egensperger R,Prehn JH

    更新日期：2012-09-01 00:00:00

  • Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits.

    abstract：:Eyeblink conditioning is a relatively simple form of associative learning that shows neurobiological and behavioral parallels across several species, including humans. Aged subjects acquire eyeblink conditioning more slowly than young ones. In addition, eyeblink conditioning effectively discriminates patients with Alz...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.03.006

    authors： Rose GM,Ong VS,Woodruff-Pak DS

    更新日期：2007-05-01 00:00:00

  • Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies.

    abstract：:We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosor...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.12.002

    authors： Gao Q,Camous X,Lu YX,Lim ML,Larbi A,Ng TP

    更新日期：2016-03-01 00:00:00

  • Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

    abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.07.014

    authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

    更新日期：2014-01-01 00:00:00