Specific neurochemical systems and memory.

abstract：:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the inter...

journal_title：Neurobiology of aging

authors： Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG

更新日期：2014-07-01 00:00:00

abstract：:We have shown previously that the TG-3 and MPM-2 antibodies recognize phosphoepitopes common to mitosis and degenerating neurons of Alzheimer's disease(AD) brain. Here, we have evaluated their occurrence in human brain biopsy tissue, and confirm that they are absent in mature neurons of adult brain, but reappear durin...

journal_title：Neurobiology of aging

authors： Vincent I,Zheng JH,Dickson DW,Kress Y,Davies P

更新日期：1998-07-01 00:00:00

abstract：:Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

journal_title：Neurobiology of aging

authors： Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

更新日期：2017-05-01 00:00:00

abstract：:To characterize the mechanisms underlying region- and age-dependent hippocampal synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing the Swedish-Indiana APP mutation. In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area bu...

journal_title：Neurobiology of aging

authors： Tozzi A,Sclip A,Tantucci M,de Iure A,Ghiglieri V,Costa C,Di Filippo M,Borsello T,Calabresi P

更新日期：2015-01-01 00:00:00

abstract：:We have developed a cell-based phenotypic automated high-content screening approach for N2a cells expressing the pro-aggregant repeat domain of tau protein (tauRDΔK), which allows analysis of a chemogenomic library of 1649 compounds for their effect on the inhibition or stimulation of intracellular tau aggregation. We...

journal_title：Neurobiology of aging

authors： Pickhardt M,Tassoni M,Denner P,Kurkowsky B,Kitanovic A,Möhl C,Fava E,Mandelkow E

更新日期：2019-04-01 00:00:00

abstract：:Positron emission tomography (PET) has been used extensively to evaluate the neuropathology of Alzheimer's disease (AD) in vivo. Radiotracers directed toward the amyloid deposition such as [(18)F]-FDDNP (2-(1-{6-[(2-[F]Fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile) and [(11)C]-PIB (Pittsburg compound ...

journal_title：Neurobiology of aging

authors： Rojas S,Herance JR,Gispert JD,Abad S,Torrent E,Jiménez X,Pareto D,Perpiña U,Sarroca S,Rodríguez E,Ortega-Aznar A,Sanfeliu C

更新日期：2013-07-01 00:00:00

abstract：:Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's...

journal_title：Neurobiology of aging

authors： Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

更新日期：2018-04-01 00:00:00

abstract：:In amyotrophic lateral sclerosis (ALS), objective biomarkers are needed for early diagnosis and progression monitoring. Reduced phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) has recently been proposed to provide such a biomarker in ALS. Here, we aimed to scrutinize this notion, evaluating both p-tau and tota...

journal_title：Neurobiology of aging

authors： Wilke C,Deuschle C,Rattay TW,Maetzler W,Synofzik M

更新日期：2015-02-01 00:00:00

abstract：:Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to el...

journal_title：Neurobiology of aging

authors： Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers R

更新日期：2012-02-01 00:00:00

abstract：:The goal of this experiment was to determine the correlations among different behavioral and neurobiological measures in aged rats. Aged Sprague-Dawley rats were given a battery of cognitive and sensorimotor tests, followed by electrophysiological assessment of sleep and biochemical measurements of various neurotransm...

journal_title：Neurobiology of aging

authors： Markowska AL,Stone WS,Ingram DK,Reynolds J,Gold PE,Conti LH,Pontecorvo MJ,Wenk GL,Olton DS

更新日期：1989-01-01 00:00:00

abstract：:Whole-exome sequencing recently identified a homozygous truncating mutation in Synaptojanin 1 (SYNJ1, PARK20), p.Arg258Gln, in 2 independent families with autosomal recessive young-onset parkinsonism with seizures and cognitive decline. This mutation's role in typical Parkinson's disease (PD) is unclear. We sequenced ...

journal_title：Neurobiology of aging

authors： Chen KH,Wu RM,Lin HI,Tai CH,Lin CH

更新日期：2015-10-01 00:00:00

abstract：:We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD wi...

journal_title：Neurobiology of aging

authors： Babiloni C,Del Percio C,Lizio R,Noce G,Lopez S,Soricelli A,Ferri R,Pascarelli MT,Catania V,Nobili F,Arnaldi D,Famà F,Orzi F,Buttinelli C,Giubilei F,Bonanni L,Franciotti R,Onofrj M,Stirpe P,Fuhr P,Gschwandtner U,

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

journal_title：Neurobiology of aging

authors： Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

更新日期：2020-12-09 00:00:00

abstract：:Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sI(AHP)), occurs in CA1 pyramidal cells in aged cognitively-impaired, but not cognitively-unimpaired, rodents. We sought to determine whether similar age-related changes in the sI(AHP) occur in pyramidal cells in th...

journal_title：Neurobiology of aging

authors： Luebke JI,Amatrudo JM

更新日期：2012-06-01 00:00:00

abstract：:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

journal_title：Neurobiology of aging

authors： Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

更新日期：2003-11-01 00:00:00

abstract：:We measured midbrain structures of 194 subjects without neurological disorders, using T2-weighted MR imaging. Age was negatively correlated with the maximum anteroposterior distance of the midbrain through the substantia nigra (MD), and the average distance from the substantia nigra to the red nucleus (SNRND), while a...

journal_title：Neurobiology of aging

authors： Sohmiya M,Tanaka M,Aihara Y,Hirai S,Okamoto K

更新日期：2001-07-01 00:00:00

abstract：:The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the i...

journal_title：Neurobiology of aging

authors： Duyckaerts C,Bennecib M,Grignon Y,Uchihara T,He Y,Piette F,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:Aging is accompanied by increased neuroinflammation, synaptic dysfunction, and cognitive deficits both in rodents and humans, yet the onset and progression of these deficits throughout the life span remain unknown. These aging-related deficits affect the quality of life and present challenges to our aging society. Her...

journal_title：Neurobiology of aging

authors： Rogers JT,Liu CC,Zhao N,Wang J,Putzke T,Yang L,Shinohara M,Fryer JD,Kanekiyo T,Bu G

更新日期：2017-05-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00

abstract：:The amyloid beta-peptide (A beta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal protein oxidation is a consequence of A beta-associated free radicals [8]. In this study we have used both in vitro and in vivo models of beta-amyloid (A beta) to...

journal_title：Neurobiology of aging

authors： Yatin SM,Varadarajan S,Link CD,Butterfield DA

更新日期：1999-05-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

journal_title：Neurobiology of aging

authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R vari...

journal_title：Neurobiology of aging

authors： Gan-Or Z,Mohsin N,Girard SL,Montplaisir JY,Ambalavanan A,Strong S,Mallett V,Laurent SB,Bourassa CV,Boivin M,Langlois M,Arnulf I,Högl B,Frauscher B,Monaca C,Desautels A,Gagnon JF,Postuma RB,Dion PA,Dauvilliers Y,Du

更新日期：2016-07-01 00:00:00

abstract：:While cytoskeletal abnormalities are prominent in the neurons of patients with Alzheimer's disease, the possibility remains that these changes are secondary to changes in the neuronal environment. The success of NGF in the therapy of Alzheimer's disease may be dependent on its ability to promote neuronal survival rath...

journal_title：Neurobiology of aging

authors： Shelanski ML

更新日期：1989-09-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00

abstract：:Since diabetes is a risk factor for Alzheimer's disease (AD), we asked if there is a functional interaction between high glucose and elevated beta amyloid peptide (Abeta) in cultured brain microvascular endothelial cells and presymptomatic AD transgenic mice. When cultured brain microvascular endothelial cells are exp...

journal_title：Neurobiology of aging

authors： Burdo JR,Chen Q,Calcutt NA,Schubert D

更新日期：2009-12-01 00:00:00

abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

journal_title：Neurobiology of aging

authors： Hartmann H,Velbinger K,Eckert A,Müller WE

更新日期：1996-07-01 00:00:00

abstract：:A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies in humans have shown that only a relatively minor neuron loss occurs with aging and that this loss is restricted to spe...

journal_title：Neurobiology of aging

authors： Calhoun ME,Kurth D,Phinney AL,Long JM,Hengemihle J,Mouton PR,Ingram DK,Jucker M

更新日期：1998-11-01 00:00:00

abstract：:We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarrier...

journal_title：Neurobiology of aging

authors： Galimberti D,Fumagalli GG,Fenoglio C,Cioffi SMG,Arighi A,Serpente M,Borroni B,Padovani A,Tagliavini F,Masellis M,Tartaglia MC,van Swieten J,Meeter L,Graff C,de Mendonça A,Bocchetta M,Rohrer JD,Scarpini E,Genetic FTD I

更新日期：2018-02-01 00:00:00

abstract：:Iron is essential for triggering oligodendrocytes to myelinate, however, in gray matter (GM) iron increases with age and is associated with age-related degenerative brain diseases. Women have lower iron levels than men, both in the periphery and in the brain, particularly in white matter (WM), possibly due to iron los...

journal_title：Neurobiology of aging

authors： Tishler TA,Raven EP,Lu PH,Altshuler LL,Bartzokis G

更新日期：2012-09-01 00:00:00

abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

journal_title：Neurobiology of aging

authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

更新日期：2007-09-01 00:00:00