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The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder.

Abstract：

:The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02-1.47, p = 0.03) but with significant heterogeneity (p = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92-1.35, p = 0.27, heterogeneity p = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Gan-Or Z,Mohsin N,Girard SL,Montplaisir JY,Ambalavanan A,Strong S,Mallett V,Laurent SB,Bourassa CV,Boivin M,Langlois M,Arnulf I,Högl B,Frauscher B,Monaca C,Desautels A,Gagnon JF,Postuma RB,Dion PA,Dauvilliers Y,Du

doi

10.1016/j.neurobiolaging.2016.03.029

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

180.e7-180.e13

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(16)30021-5

journal_volume

43

pub_type

杂志文章

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