Role of toll-like receptor 2 in ischemic demyelination and oligodendrocyte death.


:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the internal capsule resulted in a localized demyelinating lesion in mice, where loss of OL lineage cells and inflammatory cell infiltration were observed accompanied by upregulation of toll-like receptor 2 (TLR2). Intriguingly, the extent of demyelinating pathology was markedly larger in TLR2 deficient mice than that of wild-type (WT) mice. TLR2 deficient mice showed enhanced OL death and decreased phosphorylation of ERK1/2 compared with WT animals. Cultured OLs from TLR2 deficient mice were more vulnerable to oxygen-glucose deprivation than WT OLs. Applying TLR2 agonists Pam3CSK4 or Zymosan after oxygen-glucose deprivation substantially rescued WT OL death with augmentation of ERK1/2 phosphorylation. Treatment with Pam3CSK4 also reduced the extent of endothelin-1 induced ischemic demyelination in vivo. Our data indicate TLR2 may provide endogenous protective effects on ischemic demyelination and OL degeneration.


Neurobiol Aging


Neurobiology of aging


Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG




Has Abstract


2014-07-01 00:00:00














  • Using next-generation sequencing as a genetic diagnostic tool in rare autosomal recessive neurologic Mendelian disorders.

    abstract::Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

    更新日期:2013-10-01 00:00:00

  • Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

    abstract::Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

    更新日期:2013-06-01 00:00:00

  • Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

    abstract::Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

    更新日期:2015-01-01 00:00:00

  • Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.

    abstract::Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

    更新日期:2011-11-01 00:00:00

  • Genetic analysis of the SOD1 and C9ORF72 genes in Hungarian patients with amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of motor neurons. To date, more than 20 genes have been implicated in ALS, and of these, the 2 most frequently mutated are the superoxide dismutase 1 (SOD1) gene and the chromosome 9 open reading frame 72 (C9ORF72) gene. In t...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tripolszki K,Csányi B,Nagy D,Ratti A,Tiloca C,Silani V,Kereszty É,Török N,Vécsei L,Engelhardt JI,Klivényi P,Nagy N,Széll M

    更新日期:2017-05-01 00:00:00

  • Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.

    abstract::Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

    更新日期:2010-01-01 00:00:00

  • Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.

    abstract::Abnormal interaction of beta-amyloid 42 (Abeta42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investig...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Strozyk D,Launer LJ,Adlard PA,Cherny RA,Tsatsanis A,Volitakis I,Blennow K,Petrovitch H,White LR,Bush AI

    更新日期:2009-07-01 00:00:00

  • Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism.

    abstract::Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are a...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Duman RS

    更新日期:2005-12-01 00:00:00

  • Nitric oxide mediated recovery sleep is attenuated with aging.

    abstract::Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rytkönen KM,Wigren HK,Kostin A,Porkka-Heiskanen T,Kalinchuk AV

    更新日期:2010-11-01 00:00:00

  • The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats.

    abstract::Pituitary-adrenal responsiveness to stress induced by either psychological (novelty) or physiological (ether) stimuli was examined in young (3 to 6 months) and old (24 to 27 months) male and female rats. In Experiment 1, subjects were placed in a novel environment for 3 min. Blood samples were collected at 0, 15, 30, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Brett LP,Chong GS,Coyle S,Levine S

    更新日期:1983-07-01 00:00:00

  • APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum.

    abstract::We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

    journal_title:Neurobiology of aging

    pub_type: 更正并重新发布的文章,杂志文章


    authors: Johnson SA,Rogers J,Finch CE

    更新日期:1989-11-01 00:00:00

  • Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation.

    abstract::Transcranial electrical stimulation (tES) is a potentially viable tool for boosting cognitive performance in aging. However, most knowledge on tES effects is based on studies involving young adults. Here, we applied tES (transcranial random noise stimulation [tRNS] as an effective stimulation and anodal transcranial d...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Fertonani A,Pirulli C,Bollini A,Miniussi C,Bortoletto M

    更新日期:2019-10-01 00:00:00

  • The older rabbit as an animal model: implications for Alzheimer's disease.

    abstract::Eyeblink classical conditioning (EBCC) is impared in rabbits and humans during normal aging and severely disrupted in Alzheimer's disease (AD) and older Down's Syndrome patients (called DS/AD). To determine if older rabbit brains developed neuropathological evidence of Alzheimer-like pathology to account for impaired ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Woodruff-Pak DS,Trojanowski JQ

    更新日期:1996-03-01 00:00:00

  • Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice.

    abstract::Modulation of insulin-dependent signaling is emerging as a valuable therapeutic tool to target neurodegeneration. In the brain, the activation of insulin receptors promotes cell growth, neuronal repair, and protection. Altered brain insulin signaling participates in the cognitive decline seen in Alzheimer's disease pa...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Bomba M,Granzotto A,Castelli V,Massetti N,Silvestri E,Canzoniero LMT,Cimini A,Sensi SL

    更新日期:2018-04-01 00:00:00

  • Region-specific downregulation of free intracellular calcium in the aged rat brain.

    abstract::Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Hartmann H,Velbinger K,Eckert A,Müller WE

    更新日期:1996-07-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract::Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期:2013-05-01 00:00:00

  • Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.

    abstract::Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP-3 are reported to degrade amyloid beta and have several functional polymorphisms associated with other common diseases. Four common polymorphisms in each of MMP-...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Shibata N,Ohnuma T,Higashi S,Usui C,Ohkubo T,Kitajima A,Ueki A,Nagao M,Arai H

    更新日期:2005-07-01 00:00:00

  • The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.

    abstract::The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of TOMM40 "523" polymorphism on spatial navigation and its brain s...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Laczó J,Andel R,Vyhnalek M,Matoska V,Kaplan V,Nedelska Z,Lerch O,Gazova I,Moffat SD,Hort J

    更新日期:2015-06-01 00:00:00

  • Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

    abstract::Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

    更新日期:2012-04-01 00:00:00

  • Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.

    abstract::The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRN...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Matamala JM,Arias-Carrasco R,Sanchez C,Uhrig M,Bargsted L,Matus S,Maracaja-Coutinho V,Abarzua S,van Zundert B,Verdugo R,Manque P,Hetz C

    更新日期:2018-04-01 00:00:00

  • Recovery of function after brain damage: differences in aged rats?

    abstract::Age at the time of brain injury is generally considered an important determinant in recovery of function. The implication is that older individuals show less recovery. Existing data challenge this common notion, but suggest differential effects of brain damage in aged subjects. To assess these differences old rats wer...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: LeVere ND

    更新日期:1983-10-01 00:00:00

  • MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD.

    abstract::The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease (AD). However, whether SI atrophy occurs in individua...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: George S,Mufson EJ,Leurgans S,Shah RC,Ferrari C,deToledo-Morrell L

    更新日期:2011-10-01 00:00:00

  • Progressive impairment in olfactory working memory in a mouse model of Mild Cognitive Impairment.

    abstract::Patients with Mild Cognitive Impairment (MCI), exhibiting both working memory and olfactory deficits are likely to progress to Alzheimer's disease (AD). Targeting this pre-clinical AD population with disease modifying agents or cognitive enhancers represents the best strategy for halting or delaying the impact of this...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Young JW,Sharkey J,Finlayson K

    更新日期:2009-09-01 00:00:00

  • The release and uptake of excitatory amino acids in rat brain: effect of aging and oxidative stress.

    abstract::The excitatory amino acids (EAAs) L-aspartate and L-glutamate constitute the major neurotransmitters in the mammalian brain. This study established the influence of aging and oxidative stress on the release and uptake of EAAs. The high affinity uptake of D-[3H]aspartate in synaptosomal fractions of the neostriatum, hi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Palmer AM,Robichaud PJ,Reiter CT

    更新日期:1994-01-01 00:00:00

  • BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events.

    abstract::Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

    更新日期:2004-11-01 00:00:00

  • Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor.

    abstract::Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of eth...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ceccanti M,Mancinelli R,Tirassa P,Laviola G,Rossi S,Romeo M,Fiore M

    更新日期:2012-02-01 00:00:00

  • Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a genetically complex disorder for which the definite diagnosis is only accomplished postmortem. Mutations in 3 genes (APP, PSEN1, and PSEN2) are known to cause AD, but a large number of familial cases do not harbor mutations in these genes and several unidentified genes that contain diseas...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Guerreiro RJ,Lohmann E,Kinsella E,Brás JM,Luu N,Gurunlian N,Dursun B,Bilgic B,Santana I,Hanagasi H,Gurvit H,Gibbs JR,Oliveira C,Emre M,Singleton A

    更新日期:2012-05-01 00:00:00

  • Loss of place specificity in hippocampal complex spike cells of senescent rat.

    abstract::Firing characteristics of "place" cells in dorsal CA1 of hippocampus were recorded from 5 young (10-14 months) and 5 old (25-29 months) Fischer-344 rats. Animals were trained to obtain food reward on a radial 8-arm maze. Entry to the arms was controlled by the experimenter so that all 8-arm were visited in random sequ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Barnes CA,McNaughton BL,O'Keefe J

    更新日期:1983-07-01 00:00:00

  • Hippocampal hypometabolism predicts cognitive decline from normal aging.

    abstract:OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

    更新日期:2008-05-01 00:00:00

  • Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging.

    abstract::Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

    更新日期:2019-12-01 00:00:00