Role of toll-like receptor 2 in ischemic demyelination and oligodendrocyte death.


:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the internal capsule resulted in a localized demyelinating lesion in mice, where loss of OL lineage cells and inflammatory cell infiltration were observed accompanied by upregulation of toll-like receptor 2 (TLR2). Intriguingly, the extent of demyelinating pathology was markedly larger in TLR2 deficient mice than that of wild-type (WT) mice. TLR2 deficient mice showed enhanced OL death and decreased phosphorylation of ERK1/2 compared with WT animals. Cultured OLs from TLR2 deficient mice were more vulnerable to oxygen-glucose deprivation than WT OLs. Applying TLR2 agonists Pam3CSK4 or Zymosan after oxygen-glucose deprivation substantially rescued WT OL death with augmentation of ERK1/2 phosphorylation. Treatment with Pam3CSK4 also reduced the extent of endothelin-1 induced ischemic demyelination in vivo. Our data indicate TLR2 may provide endogenous protective effects on ischemic demyelination and OL degeneration.


Neurobiol Aging


Neurobiology of aging


Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG




Has Abstract


2014-07-01 00:00:00














  • The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.

    abstract::Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well 123I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alz...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Miyagawa T,Przybelski SA,Maltais D,Min HK,Jordan L,Lesnick TG,Chen Q,Graff-Radford J,Jones D,Savica R,Knopman D,Petersen R,Kremers WK,Forsberg LK,Fields JA,Ferman TJ,Allen L,Parisi J,Reichard RR,Murray M,Dickson D

    更新日期:2020-12-15 00:00:00

  • Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy.

    abstract::Telomere shortening is thought to contribute to premature senescence of satellite cells in Duchenne muscular dystrophy (DMD) muscle. Telomeric repeat binding factor-1 (TRF1) and poly (ADP-ribose) polymerase-1 (PARP1) are proteins known to modulate telomerase reverse transcriptase (TERT) activity, which controls telome...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Aguennouz M,Vita GL,Messina S,Cama A,Lanzano N,Ciranni A,Rodolico C,Di Giorgio RM,Vita G

    更新日期:2011-12-01 00:00:00

  • Screening of a neuronal cell model of tau pathology for therapeutic compounds.

    abstract::We have developed a cell-based phenotypic automated high-content screening approach for N2a cells expressing the pro-aggregant repeat domain of tau protein (tauRDΔK), which allows analysis of a chemogenomic library of 1649 compounds for their effect on the inhibition or stimulation of intracellular tau aggregation. We...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Pickhardt M,Tassoni M,Denner P,Kurkowsky B,Kitanovic A,Möhl C,Fava E,Mandelkow E

    更新日期:2019-04-01 00:00:00

  • SLC1A2 rs3794087 does not associate with essential tremor.

    abstract::A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET,...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ross JP,Rayaprolu S,Bernales CQ,Soto-Ortolaza AI,van Gerpen J,Uitti RJ,Wszolek ZK,Rajput A,Rajput AH,Rajput ML,Ross OA,Vilariño-Güell C

    更新日期:2014-04-01 00:00:00

  • Cue-related processing accounts for age differences in phasic alerting.

    abstract::Alertness is fundamental for the efficiency of information processing. A person's level of alertness refers to the system's state of general responsiveness and can be temporarily increased by presenting a neutral warning cue shortly before an event occurs (Posner and Petersen, 1990). However, effects of alerts on subs...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wiegand I,Sander MC

    更新日期:2019-07-01 00:00:00

  • Pathogenicity of exonic indels in fused in sarcoma in amyotrophic lateral sclerosis.

    abstract::Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to el...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers R

    更新日期:2012-02-01 00:00:00

  • Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

    abstract::There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,随机对照试验


    authors: Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

    更新日期:2019-05-01 00:00:00

  • Involvement of hippocampal serotonergic activity in age-related changes in exploratory behavior.

    abstract::The effect of aging on exploratory behavior was investigated in adult (5 month) and aged (28 month) CB6F1 mice. During the first 10 minutes of the test session, aged mice made fewer head dip responses and spent less time exploring the novel stimuli. Because the aged mice were observed to subsequently increase their du...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Brennan MJ,Dallob A,Friedman E

    更新日期:1981-10-01 00:00:00

  • Intermale aggression and infanticide in aged C57BL/6J male mice: behavioral deficits are not related to serum testosterone (T) levels and are not recovered by supplemental T.

    abstract::Healthy aged adult (24-26 months of age) and young adult (2-4 months of age) c57BL/6J male mice were assessed for intermale aggression, pup-killing behavior (infanticide), and circulating levels of testosterone (T). When compared to young adult male mice, aged adult males were highly variable in the exhibition of both...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Svare B,Mann M,Broida J,Kinsley C,Ghiraldi L,Miele J,Konen C

    更新日期:1983-01-01 00:00:00

  • Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model.

    abstract::During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative bur...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ferreiro E,Lanzillo M,Canhoto D,Carvalho da Silva AM,Mota SI,Dias IS,Ferreira IL,Fontes AR,Mastrella G,Pinheiro P,Valero J,Rego AC

    更新日期:2020-08-01 00:00:00

  • Neural correlates of age-related decline and compensation in visual attention capacity.

    abstract::We identified neural correlates of declined and preserved basic visual attention functions in aging individuals based on Bundesen "Theory of Visual Attention". In an interindividual difference approach, we contrasted electrophysiology of higher- and lower-performing younger and older participants. In both age groups, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wiegand I,Töllner T,Dyrholm M,Müller HJ,Bundesen C,Finke K

    更新日期:2014-09-01 00:00:00

  • Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat.

    abstract::Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

    更新日期:2001-01-01 00:00:00

  • Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age.

    abstract::Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their aetiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically nor...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Bastin ME,Clayden JD,Pattie A,Gerrish IF,Wardlaw JM,Deary IJ

    更新日期:2009-01-01 00:00:00

  • Spatio-temporal patterns of event-related potentials related to audiovisual synchrony judgments in older adults.

    abstract::Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chan YM,Pianta MJ,Bode S,McKendrick AM

    更新日期:2017-07-01 00:00:00

  • Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups.

    abstract::A group of 51 healthy elderly volunteer subjects participated in a 3- to 6-year longitudinal study of basal cortisol levels. Once per year basal cortisol levels were examined using hourly sampling over a 24-h period. Analyses of three cortisol measures (last measure obtained, mean cortisol levels across years, and the...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lupien S,Lecours AR,Schwartz G,Sharma S,Hauger RL,Meaney MJ,Nair NP

    更新日期:1996-01-01 00:00:00

  • High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain.

    abstract::Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid arte...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

    更新日期:2015-12-01 00:00:00

  • Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

    更新日期:2014-06-01 00:00:00

  • Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

    abstract::Gangliosides have been shown to be necessary for beta-amyloid (Abeta) binding and aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides. We examined Abeta-ganglioside interactions in neural tissue from mice lacking the g...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Bernardo A,Harrison FE,McCord M,Zhao J,Bruchey A,Davies SS,Jackson Roberts L 2nd,Mathews PM,Matsuoka Y,Ariga T,Yu RK,Thompson R,McDonald MP

    更新日期:2009-11-01 00:00:00

  • Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

    abstract::Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

    更新日期:2015-01-01 00:00:00

  • Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.

    abstract::An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challeng...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Neuner SM,Garfinkel BP,Wilmott LA,Ignatowska-Jankowska BM,Citri A,Orly J,Lu L,Overall RW,Mulligan MK,Kempermann G,Williams RW,O'Connell KM,Kaczorowski CC

    更新日期:2016-10-01 00:00:00

  • Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.

    abstract::The triple transgenic mouse model (3×TgAD: APPswe, TauP301L, PS1M146V) recapitulates both amyloid β (Aβ)- and tau-related lesions as well as synaptic and memory deficits. In these mice, we reported an early apathy-like behavior and alterations in synaptic plasticity appearing concomitantly with intraneuronal accumulat...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Bourgeois A,Lauritzen I,Lorivel T,Bauer C,Checler F,Pardossi-Piquard R

    更新日期:2018-11-01 00:00:00

  • Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults.

    abstract::Transcranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor t...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Opie GM,Hand BJ,Coxon JP,Ridding MC,Ziemann U,Semmler JG

    更新日期:2019-09-01 00:00:00

  • Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.

    abstract::Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in b...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Metastasio A,Rinaldi P,Tarducci R,Mariani E,Feliziani FT,Cherubini A,Pelliccioli GP,Gobbi G,Senin U,Mecocci P

    更新日期:2006-07-01 00:00:00

  • Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

    abstract::Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

    更新日期:2012-04-01 00:00:00

  • Effects of aging on transient and sustained successful memory encoding activity.

    abstract::Event-related fMRI studies have investigated age-related changes in encoding by identifying greater activity for items that are later remembered than for those that are forgotten (difference in memory, or Dm). The present study used hybrid blocked/event-related analyses to distinguish between transient Dm versus susta...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Dennis NA,Daselaar S,Cabeza R

    更新日期:2007-11-01 00:00:00

  • Activation of cerebral blood flow during a visuoperceptual task in patients with Alzheimer-type dementia.

    abstract::Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

    更新日期:1993-01-01 00:00:00

  • Age and species-dependent differences in the neurokinin B system in rat and human brain.

    abstract::Neurokinin B and its cognate neurokinin-3 receptor are expressed more in the forebrain than in brain stem structures but little is known about the primary function of this peptide system in the central processing of information. In general, few studies have specifically addressed age-related changes of tachykinins, no...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Mileusnic D,Magnuson DJ,Hejna MJ,Lorens JB,Lorens SA,Lee JM

    更新日期:1999-01-01 00:00:00

  • Modeling hippocampal neurogenesis across the lifespan in seven species.

    abstract::The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species. Data from mice (Mus musculus), rats (Rattus norvegicus), lesser hedgehog tenrecs (Echinops telfairi), macaques (Mac...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lazic SE

    更新日期:2012-08-01 00:00:00

  • Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

    abstract::Supporting the hypothesis that proteasome dysfunction is involved in Parkinson's disease (PD), McNaught et al. (2004) reported that the systemic administration of the proteasome inhibitor Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde (PSI) in rats led to the degeneration of the nigrostriatal pathway. However, several groups could ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Shin M,Jan C,Jacquard C,Jarraya B,Callebert J,Launay JM,Hantraye P,Remy P,Palfi S,Brouillet E

    更新日期:2011-11-01 00:00:00

  • Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease.

    abstract::Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding reg...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Oeda T,Umemura A,Mori Y,Tomita S,Kohsaka M,Park K,Inoue K,Fujimura H,Hasegawa H,Sugiyama H,Sawada H

    更新日期:2015-12-01 00:00:00