当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.

Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.

Abstract：

:Alzheimer's disease (AD) is the most common neurodegenerative disease and is caused by an accumulation of A beta plaque deposits in the brains. Evidence is increasing that green tea flavonoids can protect cells from A beta-mediated neurotoxicity. However, the underlying mechanism remains unclear. Here, we used a human neuronal cell line MC65 conditional expression of an amyloid precursor protein fragment (APP-C99) to investigate the protection mechanism of epigallocatechin gallate (EGCG), the main constituent of green tea. We demonstrated that treatment with EGCG reduced the A beta levels by enhancing endogenous APP nonamyloidogenic proteolytic processing. Furthermore, EGCG also decreased nuclear translocation of c-Abl and blocked APP-C99-dependent GSK3 beta activation, and these inhibitory effects occurred through the interruption of c-Abl/Fe65 interaction. Our results indicated that the neuroprotective action of EGCG may take place through some mechanisms other than the promotion of APP nonamyloidogenic proteolysis, as was reported previously.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Lin CL,Chen TF,Chiu MJ,Way TD,Lin JK

doi

10.1016/j.neurobiolaging.2007.05.012

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

81-92

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00213-8

journal_volume

30

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

    abstract：:Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the olfactory pathways. Recent studies ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.033

    authors： Martel G,Simon A,Nocera S,Kalainathan S,Pidoux L,Blum D,Leclère-Turbant S,Diaz J,Geny D,Moyse E,Videau C,Buée L,Epelbaum J,Viollet C

    更新日期：2015-02-01 00:00:00

  • Phenotypic correlations in FTDP-17.

    abstract：:Frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17) are hereditary tauopathies affecting at least 50 known kindred worldwide. Most kindred present with severe behavioral or psychiatric manifestations progressing to dementia, while some kindred first manifest a parkinsonian-plus syndrome. Nine ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(00)00202-5

    authors： Reed LA,Wszolek ZK,Hutton M

    更新日期：2001-01-01 00:00:00

  • Opiate receptor characteristics in brains from young, mature and aged mice.

    abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80066-6

    authors： Ueno E,Liu DD,Ho IK,Hoskins B

    更新日期：1988-05-01 00:00:00

  • Impact of chronic Helicobacter pylori infection on Alzheimer's disease: preliminary results.

    abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.10.021

    authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

    更新日期：2012-05-01 00:00:00

  • Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment.

    abstract：:We determined whether oxidative stress is an early event in the pathogenesis of sporadic Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions and neurofibrillary pathology in AD and mild cognitive impairment (MCI). Oxidative stress was measured as the percentage of astrocytes expre...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.01.016

    authors： Schipper HM,Bennett DA,Liberman A,Bienias JL,Schneider JA,Kelly J,Arvanitakis Z

    更新日期：2006-02-01 00:00:00

  • New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease.

    abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.03.004

    authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

    更新日期：2011-03-01 00:00:00

  • Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden.

    abstract：:The development of amyloid imaging compounds has allowed in vivo imaging of amyloid deposition. In this study, we examined the spatial patterns of amyloid deposition throughout the brain using Pittsburgh Compound Blue ((11)C-PiB) positron emission tomography data from the Baltimore Longitudinal Study of Aging. We used...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.05.030

    authors： Yotter RA,Doshi J,Clark V,Sojkova J,Zhou Y,Wong DF,Ferrucci L,Resnick SM,Davatzikos C

    更新日期：2013-12-01 00:00:00

  • Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is a genetically complex disorder for which the definite diagnosis is only accomplished postmortem. Mutations in 3 genes (APP, PSEN1, and PSEN2) are known to cause AD, but a large number of familial cases do not harbor mutations in these genes and several unidentified genes that contain diseas...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.10.009

    authors： Guerreiro RJ,Lohmann E,Kinsella E,Brás JM,Luu N,Gurunlian N,Dursun B,Bilgic B,Santana I,Hanagasi H,Gurvit H,Gibbs JR,Oliveira C,Emre M,Singleton A

    更新日期：2012-05-01 00:00:00

  • Aging alters envelope representations of speech-like sounds in the inferior colliculus.

    abstract：:Hearing impairment in older people is thought to arise from impaired temporal processing in auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level (extracellular recordings) approach to investigate how aging affects the sensitivity to temporal envelopes of speech-like sounds in rats. Sc...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.023

    authors： Parthasarathy A,Herrmann B,Bartlett EL

    更新日期：2019-01-01 00:00:00

  • Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).

    abstract：:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.06.021

    authors： Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

    更新日期：2016-10-01 00:00:00

  • Altered pericyte-endothelial relations in the rat retina during aging: implications for vessel stability.

    abstract：:Mural cells (smooth muscle cells and pericytes) regulate blood flow and contribute to vessel stability. We examined whether mural cell changes accompany age-related alterations in the microvasculature of the central nervous system. The retinas of young adult and aged Wistar rats were subjected to immunohistofluorescen...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.10.021

    authors： Hughes S,Gardiner T,Hu P,Baxter L,Rosinova E,Chan-Ling T

    更新日期：2006-12-01 00:00:00

  • Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus.

    abstract：:Age-dependent cognitive impairments have been correlated with functional and structural modifications in the hippocampal formation. In particular, the brain endogenous steroid pregnenolone-sulfate (Preg-S) is a cognitive enhancer whose hippocampal levels have been linked physiologically to cognitive performance in sen...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.03.013

    authors： Mayo W,Lemaire V,Malaterre J,Rodriguez JJ,Cayre M,Stewart MG,Kharouby M,Rougon G,Le Moal M,Piazza PV,Abrous DN

    更新日期：2005-01-01 00:00:00

  • Motor function in young and aged hemiplegic rats: effects of a Ginkgo biloba extract.

    abstract：:We have previously shown beneficial effects of a Ginkgo biloba extract (EGb761-IPSEN) in accelerating functional recovery from hemiplegia induced by unilateral motor cortex ablation. Here, we report the behavioral and histological effects of various dose regimes of EGb761. In young rats (3 months), 10 mg/kg/day for 7 ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00007-9

    authors： Brailowsky S,Montiel T

    更新日期：1997-03-01 00:00:00

  • Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging.

    abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.07.021

    authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

    更新日期：2006-03-01 00:00:00

  • Skewed X-chromosome inactivation and XIST locus methylation levels do not contribute to the lower prevalence of Parkinson's disease in females.

    abstract：:Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewe...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.05.021

    authors： Sharma A,Kaut O,Pavlova A,Fröhlich H,Ahmad A,Schmitt I,El-Maarri O,Oldenburg J,Wüllner U

    更新日期：2017-09-01 00:00:00

  • Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline.

    abstract：:Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of DNA methylation. We investigated the effect of a damaging coding var...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.02.001

    authors： Flitton M,Rielly N,Warman R,Warden D,Smith AD,Macdonald IA,Knight HM

    更新日期：2019-06-01 00:00:00

  • Associations of carotid arterial compliance and white matter diffusion metrics during midlife: modulation by sex.

    abstract：:Sex differences in cerebral white matter (WM) aging have been debated extensively over the past 2 decades without unequivocal resolution. We aimed to determine if the effects of age and arterial stiffness on WM microstructure differ between sexes. Artery elasticity via carotid artery compliance (CAC) and WM diffusion ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.02.012

    authors： Pasha EP,Birdsill AC,Oleson S,Tanaka H,Haley AP

    更新日期：2018-06-01 00:00:00

  • Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.

    abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.06.018

    authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

    更新日期：2007-09-01 00:00:00

  • Longitudinal change in memory performance associated with HTR2A polymorphism.

    abstract：:We present a fresh approach to evaluating association with candidate genes and cognitive change by testing association for parameters describing individual growth curves from twins. Moderate genetic influences on memory in aging adults has been shown in quantitative genetic studies. A recently reported, association of...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.12.009

    authors： Reynolds CA,Jansson M,Gatz M,Pedersen NL

    更新日期：2006-01-01 00:00:00

  • Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.

    abstract：:Exercise has emerged as a powerful variable that can improve cognitive function and delay age-associated cognitive decline and Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. To determine if protective mechanisms may occur at the transcriptional level, we used microarrays to investi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.02.012

    authors： Berchtold NC,Prieto GA,Phelan M,Gillen DL,Baldi P,Bennett DA,Buchman AS,Cotman CW

    更新日期：2019-06-01 00:00:00

  • Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.

    abstract：:As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.11.026

    authors： Jiang T,Yu JT,Zhu XC,Tan MS,Gu LZ,Zhang YD,Tan L

    更新日期：2014-06-01 00:00:00

  • Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

    abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.029

    authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

    更新日期：2015-01-01 00:00:00

  • Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS.

    abstract：:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.09.020

    authors： Das MM,Svendsen CN

    更新日期：2015-02-01 00:00:00

  • Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer's disease.

    abstract：:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90017-r

    authors： Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

    更新日期：1992-01-01 00:00:00

  • Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.

    abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.10.007

    authors： Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

    更新日期：2012-05-01 00:00:00

  • Age-related neurofilament phosphorylation in normal human brains.

    abstract：:An age-related phosphorylation of the 200kD neurofilament protein (NF200) has been observed in the axons of cerebellar basket cells of normal human fixed brain tissue from individuals older than 60 years, but not in younger individuals. The probe for this study was the monoclonal antibody SMI-34 which detects a phosph...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(89)90059-6

    authors： Blanchard BJ,Ingram VM

    更新日期：1989-05-01 00:00:00

  • Altered tubulin distribution in the hypothalamus of aging female C57BL/6J mice.

    abstract：:The effects of age and estradiol on hypothalamic content and distribution of tubulin and calmodulin were examined by radioimmunoassay in ovariectomized C57BL/6J female mice. A small (14%) increase in particulate tubulin, but not soluble tubulin, was found in the hypothalamus of reproductively senescent mice (20 months...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(85)90008-9

    authors： May PC,Finch CE

    更新日期：1985-01-01 00:00:00

  • Divergent brain network connectivity in amyotrophic lateral sclerosis.

    abstract：:Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional connectivity and executive fun...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.04.015

    authors： Agosta F,Canu E,Valsasina P,Riva N,Prelle A,Comi G,Filippi M

    更新日期：2013-02-01 00:00:00

  • Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study.

    abstract：OBJECTIVE:To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD). METHODS:25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG- positron emission tomography. Patient scans were compared w...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2003.10.007

    authors： Diehl J,Grimmer T,Drzezga A,Riemenschneider M,Förstl H,Kurz A

    更新日期：2004-09-01 00:00:00

  • beta-Amyloid (A beta) deposition in the brains of aged orangutans.

    abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00012-2

    authors： Gearing M,Tigges J,Mori H,Mirra SS

    更新日期：1997-03-01 00:00:00