Abstract：
:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons. In a rodent model of familial amyotrophic lateral sclerosis (ALS) overexpressing mutant superoxide dismutase 1 (SOD1), the rate of astrocytes acquiring a senescent phenotype is accelerated and they subsequently provide less support to motor neurons. This can be partially reversed by glial cell line-derived neurotrophic factor (GDNF). Replacing aging astrocytes with young ones producing GDNF may therefore have a significant survival promoting affect on aging motor neurons and those lost through diseases such as ALS.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Das MM,Svendsen CNdoi
10.1016/j.neurobiolaging.2014.09.020subject
Has Abstractpub_date
2015-02-01 00:00:00pages
1130-9issue
2eissn
0197-4580issn
1558-1497pii
S0197-4580(14)00625-3journal_volume
36pub_type
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