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Age effects on atrophy rates of entorhinal cortex and hippocampus.

Abstract：

:The effects of age, subcortical vascular disease, apolipoprotein E (APOE) epsilon4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, and white matter hyperintensities (WMH) and the presence of lacunes were assessed on MR images. Age was significantly associated with increased atrophy rates of 0.04+/-0.02% per year for ERC and 0.05+/-0.02% per year for hippocampus. Atrophy rates of hippocampus, but not that of ERC increased with presence of lacunes, in addition to age. WMH, APOE epsilon4 and hypertension had no significant effect on atrophy rates. In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Du AT,Schuff N,Chao LL,Kornak J,Jagust WJ,Kramer JH,Reed BR,Miller BL,Norman D,Chui HC,Weiner MW

doi

10.1016/j.neurobiolaging.2005.03.021

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

733-40

issue

5

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(05)00138-7

journal_volume

27

pub_type

杂志文章

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