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Place cells of aged rats in two visually identical compartments.

Abstract：

:Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639):272-5; Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, et al. Cognitive aging and the hippocampus: how old rats represent new environments. J Neurosci 2004;24(15):3870-8]. To examine whether the impairment in hippocampal processing extends to conditions in which self-motion provides the cues for environmental change, we have analyzed spatial firing patterns of hippocampal pyramidal neurons in young and aged rats, as well as in young rats with selective cholinergic lesions, another model of cognitive aging. The rats walked between two visually identical environments, pitting self-motion cues that indicated environmental change against visual inputs that indicated no differences between environments. Our results indicated that place cells in both aged and cholinergic-lesioned rats were equally likely as those of young rats to create new spatial representations in the second compartment. These findings suggest that the hippocampal network of aged rats is able to process changes in internally generated cues without rigidity, but that incomplete processing of external landmark cues may lead to impaired spatial learning.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

doi

10.1016/j.neurobiolaging.2004.09.006

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

1099-106

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(04)00305-7

journal_volume

26

pub_type

杂志文章

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