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Different trajectories of decline for global form and global motion processing in aging, mild cognitive impairment and Alzheimer's disease.

Abstract：

:The visual processing of complex motion is impaired in Alzheimer's disease (AD). However, it is unclear whether these impairments are biased toward the motion stream or part of a general disruption of global visual processing, given some reports of impaired static form processing in AD. Here, for the first time, we directly compared the relative preservation of motion and form systems in AD, mild cognitive impairment, and healthy aging, by measuring coherence thresholds for well-established global rotational motion and static form stimuli known to be of equivalent complexity. Our data confirm a marked motion-processing deficit specific to some AD patients, and greater than any form-processing deficit for this group. In parallel, we identified a more gradual decline in static form recognition, with thresholds raised in mild cognitive impairment patients and slightly further in the AD group compared with controls. We conclude that complex motion processing is more vulnerable to decline in dementia than complex form processing, perhaps owing to greater reliance on long-range neural connections heavily targeted by AD pathology.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Porter G,Wattam-Bell J,Bayer A,Haworth J,Braddick O,Atkinson J,Tales A

doi

10.1016/j.neurobiolaging.2017.03.004

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

17-24

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(17)30075-1

journal_volume

56

pub_type

杂志文章

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