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High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain.

Abstract：

:Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid artery occlusion in young (8-9 weeks old, n = 8) and old (2 year olds, n = 6) anesthetized rats. Sham-operated animals of both age groups served as control (n = 12). Electrocorticogram, direct current potential, and cerebral blood flow (CBF) variations were acquired via a small craniotomy above the parietal cortex. SDs were elicited by KCl through a second craniotomy distal to the recording site. Ischemia and age delayed the recovery from SD. CBF decreased progressively during ischemia in the old animals selectively, and inverse neurovascular coupling with SD evolved in the old but not in the young ischemic group. We propose that (mal)adaptation of cerebrovascular function with aging impairs the SD-related CBF response, which is implicated in the intensified expansion of ischemic damage in the old brain.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

doi

10.1016/j.neurobiolaging.2015.08.014

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

3269-3277

issue

12

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(15)00425-X

journal_volume

36

pub_type

杂志文章

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