Abstract:
:The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object recognition task. We found profound deficits in 8-week-old mice. Animals this age were not impaired on the Morris water maze task. TgCRND8 and littermate controls did not differ in their duration of object exploration or optokinetic responses. Thus, visual and motor dysfunction did not confound the phenotype. Object memory deficits point to the frontal cortex and hippocampus as early targets of functional disruption. Indeed, we observed altered levels of brain-derived neurotrophic factor (BDNF) messenger ribonucleic acid (mRNA) in these brain regions of preplaque TgCRND8 mice. Our findings suggest that object recognition provides an early index of cognitive impairment associated with amyloid exposure and reduced brain-derived neurotrophic factor expression in the TgCRND8 mouse.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Francis BM,Kim J,Barakat ME,Fraenkl S,Yücel YH,Peng S,Michalski B,Fahnestock M,McLaurin J,Mount HTdoi
10.1016/j.neurobiolaging.2010.04.003subject
Has Abstractpub_date
2012-03-01 00:00:00pages
555-63issue
3eissn
0197-4580issn
1558-1497pii
S0197-4580(10)00160-0journal_volume
33pub_type
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